725237-11-6
Chemical Structure
SYK-IN-14
- CAS No.: 725237-11-6
- Formula:C21H27N7O3
- Molecular Weight:425.48
InChIKey: DVAXQAPODFQWRX-CVEARBPZSA-N
SMILES: NC(C(C1=NC=CN1C(N[C@@H]2[C@@H](CCCC2)N)=N3)=C3NC4=CC(OC)=CC(OC)=C4)=O
Biological Activity: SYK-IN-14 is an orally active Syk and ZAP-70 inhibitor with human Syk IC50 of 0.006 μM, human ZAP-70 IC50 of 0.23 μM. SYK-IN-14 functionally inhibits Syk kinase activity in vitro. SYK-IN-14 functionally inhibits ZAP-70 kinase activity in vitro. SYK-IN-14 suppresses passive cutaneous anaphylaxis reaction in Mus musculus mice. SYK-IN-14 suppresses Concanavalin A (HY-P2149)-induced IL-2 production in Mus musculus mice. SYK-IN-14 can be used for the research of allergic disorders and autoimmune diseases[1].
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SYK-IN-14 | SYK-IN-14 is an orally active Syk and ZAP-70 inhibitor with human Syk IC50 of 0.006 μM, human ZAP-70 IC50 of 0.23 μM. SYK-IN-14 functionally inhibits Syk kinase activity in vitro. SYK-IN-14 functionally inhibits ZAP-70 kinase activity in vitro. SYK-IN-14 suppresses passive cutaneous anaphylaxis reaction in Mus musculus mice. SYK-IN-14 suppresses Concanavalin A (HY-P2149)-induced IL-2 production in Mus musculus mice. SYK-IN-14 can be used for the research of allergic disorders and autoimmune diseases. | |||||||||||||||||||||
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