2. Protein Tyrosine Kinase/RTK Apoptosis
  3. Syk Apoptosis
  4. SYK-IN-15

SYK-IN-15 is an orally active spleen tyrosine kinase (SYK) inhibitor with an IC50 of 10.9 nM. SYK-IN-15 induces cell cycle S-phase arrest and cell apoptosis. SYK-IN-15 inhibits cancer cell colony formation and exerts antiproliferative effects on cancer cells. SYK-IN-15 can be used for the research of solid tumors (ovarian cancer, breast cancer, liver cancer).

For research use only. We do not sell to patients.

SYK-IN-15

SYK-IN-15 Chemical Structure

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SYK-IN-15 Related Antibodies

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Description

SYK-IN-15 is an orally active spleen tyrosine kinase (SYK) inhibitor with an IC50 of 10.9 nM. SYK-IN-15 induces cell cycle S-phase arrest and cell apoptosis. SYK-IN-15 inhibits cancer cell colony formation and exerts antiproliferative effects on cancer cells. SYK-IN-15 can be used for the research of solid tumors (ovarian cancer, breast cancer, liver cancer)[1].

In Vitro

SYK-IN-15 (Compound B13) (1-10 μM; 24 h) exerts potent antiproliferative effects on SKOV3, MDA-MB-231 and HepG2 cells, with IC50 values of 10.39 μM, 64.48 μM and 4.49 μM, respectively[1].
SYK-IN-15 (2.5-10 μM; 14 days) inhibits the colony formation of SKOV3 cells in a dose-dependent manner[1].
SYK-IN-15 (2.5-10 μM; 24 h) induces dose-dependent S-phase cell cycle arrest in SKOV3 cells[1].
SYK-IN-15 (2.5-10 μM; 24 h) promotes apoptosis of SKOV3 cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SYK-IN-15 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: SKOV3 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 14 days
Result: Dose-dependently suppressed the clonogenic potential of SKOV3 cells.

Cell Cycle Analysis[1]

Cell Line: SKOV3 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Induced dose-dependent S phase cell cycle arrest in SKOV3 cells.

Apoptosis Analysis[1]

Cell Line: SKOV3 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Dose-dependently induced apoptosis.
In Vivo

SYK-IN-15 (Compound B13) (30-60 mg/kg; p.o.; daily; 21 days) dose-dependently inhibits SKOV3 ovarian cancer xenograft tumor growth in BALB/c nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (female, 6 weeks old, SKOV3 cells subcutaneous xenograft)[1]
Dosage: 30 mg/kg; 60 mg/kg
Administration: p.o.; daily; 21 days
Result: Reduced tumor volume to 98.35 mm3 (30 mg/kg group) and 78.51 mm3 (60 mg/kg group), compared to 237.7 mm3 in control group.
Achieved tumor inhibition rates of 58.62% (30 mg/kg group) and 66.97% (60 mg/kg group).
Reduced tumor weight to 83.26 mg (30 mg/kg group) and 53.10 mg (60 mg/kg group), compared to 235.3 mg in control group.
Showed no significant differences in body weight or major organ weights (heart, liver, spleen, lung, kidney) between treated and control groups.
Exhibited no significant organ abnormalities via histopathological analysis.
Molecular Weight

513.64

Formula

C28H35N9O
SMILES

CC(C)OC(C1)CN1C(CC2)CCN2C(C=C3)=C(C)C=C3NC4=NC(C5=NC(N)=CN=C5)=CN6C4=NC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SYK-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SYK-IN-15SykApoptosisSpleen tyrosine kinasespleen tyrosine kinasexenograft mouse modelsGLN462ALA451SYKHepG2liver microsomesASP512MDA-MB-231SKOV3Inhibitorinhibitorinhibit

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