Dehydroabietinol

Cat. No.: HY-N3702 Purity: 98.90%: Data Sheet
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Dehydroabietinol is a SYK inhibitor with an IC₅₀ of 46.4 μM. Dehydroabietinol inhibits the growth of Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes and Leishmania infantum promastigotes. Dehydroabietinol indirectly inhibits the growth of Plasmodium falciparum, alters the erythrocyte membrane, and induces spherostomatocyte transformation and endovesicle formation. Dehydroabietinol can be used in studies related to immune-mediated diseases, Chagas disease, leishmaniasis and malaria.

For research use only. We do not sell to patients.

Dehydroabietinol Chemical Structure

CAS No. : 3772-55-2

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1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	44.14 μM Compound: 2; DHO	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
Erythrocyte	IC₅₀	28 μM Compound: 131	Cytotoxicity against erythrocytes assessed as morphological changes Cytotoxicity against erythrocytes assessed as morphological changes	[PMID: 19299148]
HEK293	IC₅₀	> 100 μg/mL Compound: 26	Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells Inhibition of TNF-alpha-induced NF-kappaB activity in human pNF-kappaB-luc-293 cells	[PMID: 20022253]
HeLa	IC₅₀	13 μg/mL Compound: 5,dehydroabietinol	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 19892441]
HeLa	IC₅₀	15.7 μM Compound: 18-hydroxydehydroabietane	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30684866]
HepG2	IC₅₀	45.7 μM Compound: 2; DHO	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
Jurkat	IC₅₀	9.7 μg/mL Compound: 5,dehydroabietinol	Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay	[PMID: 19892441]
L02	IC₅₀	37.16 μM Compound: 2; DHO	Antiproliferative activity against human L02 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human L02 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
LoVo	IC₅₀	9.2 μg/mL Compound: 26	Antiproliferative activity against human LoVo cells Antiproliferative activity against human LoVo cells	[PMID: 20022253]
MGC-803	IC₅₀	42.81 μM Compound: 2; DHO	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
QGY-7703	IC₅₀	> 25 μg/mL Compound: 26	Antiproliferative activity against human QGY7703 cells Antiproliferative activity against human QGY7703 cells	[PMID: 20022253]
RAW264.7	IC₅₀	> 100 μg/mL Compound: 26	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release	[PMID: 20022253]
T-24	IC₅₀	> 50 μM Compound: 2; DHO	Antiproliferative activity against human T24 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay Antiproliferative activity against human T24 cells assessed as reduction in cell viability measured for 24 hrs by MTT assay	[PMID: 37122546]
Vero	IC₅₀	17 μg/mL Compound: 19	Concentration required for 50% inhibition of herpes simplex virus 2(HSV-2) using standard plaque reduction assay in vero cells Concentration required for 50% inhibition of herpes simplex virus 2(HSV-2) using standard plaque reduction assay in vero cells	10.1016/S0960-894X(01)80236-5
Vero	IC₅₀	38 μg/mL Compound: 5,dehydroabietinol	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 19892441]

In Vitro

Dehydroabietinol (72 h) potently inhibits the growth of epimastigotes of Trypanosoma cruzi (CL-B5 clone), with an IC₅₀ of 66 μg/mL^[2].
Dehydroabietinol (48 h) inhibits the growth of promastigotes of Leishmania braziliensis (MHOM/BR/75/M2904), with an IC₅₀ of 63 μg/mL^[2].
Dehydroabietinol (incubated for 48 h) inhibits the growth of promastigotes of Leishmania infantum (MHOM/FR/91/LEM2259V), with an IC₅₀ value of 40 μg/mL^[2].
Dehydroabietinol inhibits the growth of chloroquine (HY-17589A)-sensitive P. falciparum strain 3D7 (IC₅₀ = 25.6 μM) and chloroquine-resistant P. falciparum strain Dd2 (IC₅₀ = 27.4 μM) cultured in vitro in human red blood cells^[3].
Dehydroabietinol exhibits in vitro cytotoxicity against KB-3-1 cancer cells (IC₅₀ = 28.0 μM) and KB-V1 cancer cells (IC₅₀ = 30.2 μM)^[3].
Dehydroabietinol (0.78-400 μg/mL; 48 h) induces concentration-dependent morphological changes (including stomatocyte formation, swelling and lysis) and endovesiculation in normal human red blood cells after 48 h of incubation^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

286.45

Formula

C₂₀H₃₀O

CAS No.

3772-55-2

Appearance

Oil

Color

Colorless to light yellow

SMILES

C[C@@]12C3=CC=C(C(C)C)C=C3CC[C@@]1([H])[C@@](C)(CCC2)CO

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 98.90%

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Data Sheet (272 KB) SDS (251 KB)

COA (249 KB) HNMR (139 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Gao JB, et al. Isolation, Characterization, and Structure-Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors. J Nat Prod. 2018;81(4):998-1006. [Content Brief]

[2]. Pertino MW, et al. Antiprotozoal Activity of Triazole Derivatives of Dehydroabietic Acid and Oleanolic Acid. Molecules. 2017;22(3):369. Published 2017 Feb 28.

[3]. Ziegler HL, et al. Possible artefacts in the in vitro determination of antimalarial activity of natural products that incorporate into lipid bilayer: apparent antiplasmodial activity of dehydroabietinol, a constituent of Hyptis suaveolens. Planta Med. 2002;68(6):547-549.