1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. O-Desmethyl Midostaurin

O-Desmethyl Midostaurin (Synonyms: CGP62221; O-Desmethyl PKC412)

Cat. No.: HY-129491
Handling Instructions

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

For research use only. We do not sell to patients.

O-Desmethyl Midostaurin Chemical Structure

O-Desmethyl Midostaurin Chemical Structure

CAS No. : 740816-86-8

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Description

O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

IC50 & Target

IC50: active metabolite of Midostaurin[1]

Molecular Weight

556.61

Formula

C₃₄H₂₈N₄O₄

CAS No.

740816-86-8

SMILES

O=C(N([[email protected]@H]1C[[email protected]]([H])(N2C3=C4C=CC=C3)O[[email protected]](C)(N5C6=C2C4=C(C(NC7)=O)C7=C6C8=C5C=CC=C8)[[email protected]@H]1O)C)C9=CC=CC=C9

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

O-Desmethyl MidostaurinCGP62221O-Desmethyl PKC412CGP 62221CGP-62221PKCProtein kinase CactivemetabolitePKC412indicatorInhibitorinhibitorinhibit

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O-Desmethyl Midostaurin
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