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Cat. No.: HY-W751181

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O-Desmethyl midostaurin-¹³C₆

(Synonyms: CGP62221-¹³C₆; O-Desmethyl PKC412-¹³C₆)

O-Desmethyl midostaurin-¹³C₆ (CGP62221-¹³C₆; O-Desmethyl PKC412-¹³C₆) is the ¹³C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo. Midostaurin is a multi-targeted protein kinase inhibitor?with?IC₅₀?ranging from 22-500 nM.

For research use only. We do not sell to patients.

Formula: C₂₈¹³C₆H₂₈N₄O₄
Molecular Weight:562.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

O-Desmethyl midostaurin-¹³C₆ Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

O-Desmethyl midostaurin-¹³C₆ (CGP62221-¹³C₆; O-Desmethyl PKC412-¹³C₆) is the ¹³C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo^[1]. Midostaurin is a multi-targeted protein kinase inhibitor?with?IC₅₀?ranging from 22-500 nM.

All PKC Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 740816-86-8
Molecular Weight 562.57
Formula C₂₈¹³C₆H₂₈N₄O₄
SMILES

O[C@@H]1[C@@H](C[C@H]2O[C@@]1(N3C4=C(C5=C3C6=C(C7=C(N26)C=CC=C7)C8=C5CNC8=O)C=CC=C4)C)N(C)C([13C]9=[13CH][13CH]=[13CH][13CH]=[13CH]9)=O
Synonyms

CGP62221-¹³C₆; O-Desmethyl PKC412-¹³C₆
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
References

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O-Desmethyl midostaurin-13C6

All PKC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

O-Desmethyl midostaurin-13C6 Related Classifications

HY-W751181 Related Classifications

O-Desmethyl midostaurin-¹³C₆

O-Desmethyl midostaurin-¹³C₆ Related Classifications