2. MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. p38 MAPK Syk Src
  4. TOP1362

TOP1362 is a narrow spectrum kinase inhibitor. TOP1362 is a potent inhibitor of P38-α and Syk kinases with Kd values of 26 and 18 nM, respectively and an IC50 of 14 nM in the Src kinase activity assay. TOP1362 potently inhibits P38-α, Src and Syk. TOP1362 can be used in the research of dry eye syndrome.

For research use only. We do not sell to patients.

TOP1362

TOP1362 Chemical Structure

CAS No. : 1630203-25-6

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TOP1362 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

View All Src Isoform Specific Products:

View All Isoforms
Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

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Description

TOP1362 is a narrow spectrum kinase inhibitor. TOP1362 is a potent inhibitor of P38-α and Syk kinases with Kd values of 26 and 18 nM, respectively and an IC50 of 14 nM in the Src kinase activity assay. TOP1362 potently inhibits P38-α, Src and Syk. TOP1362 can be used in the research of dry eye syndrome[1].

IC50 & Target[1]

p38α

 

Molecular Weight

825.97

Formula

C43H51N7O8S
CAS No.
SMILES

O=C(NCCCN1CCOCC1)C2=CC(OC)=CC(NC3=NC=CC(OC4=C5C=CC=CC5=C(NC(NC6=CC(C(C)(C)C)=CC(NS(=O)(C)=O)=C6OC)=O)C=C4)=C3)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TOP1362 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TOP13621630203-25-6TOP 1362TOP-1362p38 MAPKSykSrcSpleen tyrosine kinasedry eye syndromeInhibitorinhibitorinhibit

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