1630203-25-6
Chemical Structure
TOP1362
- CAS No.: 1630203-25-6
- Formula:C43H51N7O8S
- Molecular Weight:825.97
IUPAC Name: 3-((4-((4-(3-(5-(tert-butyl)-2-methoxy-3-(methylsulfonamido)phenyl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-5-methoxy-N-(3-morpholinopropyl)benzamide
InChIKey: NIMKGKUGIJVPTM-UHFFFAOYSA-N
SMILES: O=C(NCCCN1CCOCC1)C2=CC(OC)=CC(NC3=NC=CC(OC4=C5C=CC=CC5=C(NC(NC6=CC(C(C)(C)C)=CC(NS(=O)(C)=O)=C6OC)=O)C=C4)=C3)=C2
Biological Activity: TOP1362 is a narrow spectrum kinase inhibitor. TOP1362 is a potent inhibitor of P38-α and Syk kinases with Kd values of 26 and 18 nM, respectively and an IC50 of 14 nM in the Src kinase activity assay. TOP1362 potently inhibits P38-α, Src and Syk. TOP1362 can be used in the research of dry eye syndrome[1].
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TOP1362 | TOP1362 is a narrow spectrum kinase inhibitor. TOP1362 is a potent inhibitor of P38-α and Syk kinases with Kd values of 26 and 18 nM, respectively and an IC50 of 14 nM in the Src kinase activity assay. TOP1362 potently inhibits P38-α, Src and Syk. TOP1362 can be used in the research of dry eye syndrome. | |||||||||||||||||||||
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