2. Protein Tyrosine Kinase/RTK
  3. Syk
  4. Syk-IN-8

Syk-IN-8 (compound 19q) is a Syk inhibitor, with antiproliferative activity against multiple hematological tumour cells. Syk-IN-8 inhibits PLCγ2 phosphorylation, can be used for research in blood cancers.

For research use only. We do not sell to patients.

Syk-IN-8

Syk-IN-8 Chemical Structure

CAS No. : 2568963-01-7

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Syk-IN-8 Related Antibodies

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Description

Syk-IN-8 (compound 19q) is a Syk inhibitor, with antiproliferative activity against multiple hematological tumour cells. Syk-IN-8 inhibits PLCγ2 phosphorylation, can be used for research in blood cancers[1].

Cellular Effect
Cell Line Type Value Description References
DOHH-2 IC50
8.68 nM
Compound: 19q
Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
[PMID: 37423126]
Daudi IC50
719 nM
Compound: 19q
Antiproliferative activity against human Daudi cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human Daudi cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
[PMID: 37423126]
MV4-11 IC50
1.5 nM
Compound: 19q
Inhibition of cell viability in human MV4-11 cells incubated for 72 hrs by Cell Titer Glo assay
Inhibition of cell viability in human MV4-11 cells incubated for 72 hrs by Cell Titer Glo assay
[PMID: 37423126]
Ramos IC50
18 nM
Compound: 19q
Inhibition of cell growth in serum-starved human Ramos cells incubated for 1 hr followed by anti-human IgM F(ab)2 measured after 5 mins
Inhibition of cell growth in serum-starved human Ramos cells incubated for 1 hr followed by anti-human IgM F(ab)2 measured after 5 mins
[PMID: 37423126]
Rec1 IC50
34.3 nM
Compound: 19q
Antiproliferative activity against human REC1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human REC1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
[PMID: 37423126]
SU-DHL-6 IC50
216 nM
Compound: 19q
Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
[PMID: 37423126]
TMD8 IC50
10.9 nM
Compound: 19q
Antiproliferative activity against human TMD8 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human TMD8 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
[PMID: 37423126]
Molecular Weight

442.52

Formula

C23H26N10
CAS No.
SMILES

CC(C)N1CCN(CC1)C2=CC=C3N=C(NC3=C2)C4=NNC=C4NC5=C6C(NC=C6)=NC=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Syk-IN-8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Syk-IN-82568963-01-7SykSpleen tyrosine kinaseInhibitorinhibitorinhibit

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