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Cat. No.: HY-155513

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Syk-IN-8

Syk-IN-8 (compound 19q) is a Syk inhibitor, with antiproliferative activity against multiple hematological tumour cells. Syk-IN-8 inhibits PLCγ2 phosphorylation, can be used for research in blood cancers.

For research use only. We do not sell to patients.

CAS No.: 2568963-01-7
Formula: C₂₃H₂₆N₁₀
Molecular Weight:442.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Syk-IN-8 Chemical Structure

CAS No.: 2568963-01-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Daudi	IC₅₀	719 nM Compound: 19q	Antiproliferative activity against human Daudi cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human Daudi cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
DOHH-2	IC₅₀	8.68 nM Compound: 19q	Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
MV4-11	IC₅₀	1.5 nM Compound: 19q	Inhibition of cell viability in human MV4-11 cells incubated for 72 hrs by Cell Titer Glo assay Inhibition of cell viability in human MV4-11 cells incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
Ramos	IC₅₀	18 nM Compound: 19q	Inhibition of cell growth in serum-starved human Ramos cells incubated for 1 hr followed by anti-human IgM F(ab)2 measured after 5 mins Inhibition of cell growth in serum-starved human Ramos cells incubated for 1 hr followed by anti-human IgM F(ab)2 measured after 5 mins	[PMID: 37423126]
Rec1	IC₅₀	34.3 nM Compound: 19q	Antiproliferative activity against human REC1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human REC1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
SU-DHL-6	IC₅₀	216 nM Compound: 19q	Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human SU-DHL-6 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]
TMD8	IC₅₀	10.9 nM Compound: 19q	Antiproliferative activity against human TMD8 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human TMD8 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 37423126]

Chemical Information

CAS No. 2568963-01-7
Molecular Weight 442.52
Formula C₂₃H₂₆N₁₀
SMILES

CC(C)N1CCN(CC1)C2=CC=C3N=C(NC3=C2)C4=NNC=C4NC5=C6C(NC=C6)=NC=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bingbing Cui, et al. Discovery of 3-(1H-benzo[d]imidazole-2-yl)-1H-pyrazol-4 -amine derivatives as novel and potent syk inhibitors for the treatment of hematological malignancies. European Journal of Medicinal Chemistry. Volume 258, 5 October 2023, 115597.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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