2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Hydroxocobalamin

Hydroxocobalamin  (Synonyms: Vitamin B12a)

Cat. No.: HY-B2209 Purity: 99.32%
COA
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Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B12 deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease.

For research use only. We do not sell to patients.

Hydroxocobalamin

Hydroxocobalamin Chemical Structure

CAS No. : 13422-51-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Hydroxocobalamin:

Hydroxocobalamin Related Antibodies

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Description

Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B12 deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease[1][2][3][4][5][6].

In Vitro

Hydroxocobalamin (1 mM, 5 mins) recovers sodium cyanide-induced inotropy decrease in cardiac papillary muscle[1].
Hydroxocobalamin (500 μM, 10 mins) decreases intracellular cyanide in fibroblasts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydroxocobalamin Related Antibodies
In Vivo

Hydroxocobalamin (150 mg/kg, i.v.) maintains higher systolic blood pressure in both controlled and uncontrolled hemorrhage swine models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Yorkshire swine (Sus scrofa); hemorrhage model, induced by volume-controlled and uncontrolled hemorrhage[2]
Dosage: 150 mg/kg
Administration: Intravenously injection
Result: Maintained higher systolic blood pressure.
Heart rate (HR), cardiac output (CO), Spo2 and vascular resistance were comparable with whole blood.
Clinical Trial
Molecular Weight

1346.36

Formula

C62H89CoN13O15P
CAS No.
Appearance

Solid

Color

Purple to reddish brown

SMILES

C[C@@]12[N]([Co+3]34([N]5=C[N@@]([C@@H](O[C@H](CO)[C@H]6OP7([O-])=O)[C@@H]6O)C8=C5C=C(C)C(C)=C8)([OH-])[N-]9C2[C@H](CC(N)=O)[C@@](C)(CCC(NC[C@H](C)O7)=O)C9=C(C)C([C@@H](CCC(N)=O)C%10(C)C)=[N]3C%10=CC%11=[N]4C([C@](CC(N)=O)(C)[C@@H]%11CCC(N)=O)=C%12C)=C%12[C@@H](CCC(N)=O)[C@]1(C)CC(N)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (18.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7427 mL 3.7137 mL 7.4274 mL
5 mM 0.1485 mL 0.7427 mL 1.4855 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.32%

SDS (393 KB)

COA (277 KB) HNMR (262 KB) CNMR (241 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7427 mL 3.7137 mL 7.4274 mL 18.5686 mL
5 mM 0.1485 mL 0.7427 mL 1.4855 mL 3.7137 mL
10 mM 0.0743 mL 0.3714 mL 0.7427 mL 1.8569 mL
15 mM 0.0495 mL 0.2476 mL 0.4952 mL 1.2379 mL
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Hydroxocobalamin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxocobalamin13422-51-0Vitamin B12aEndogenous MetaboliteAcute kidney injurysafetypeak serum concentrationsmoke inhalationvitamin B12cyanidediastolic blood pressurecyanide poisoningsystolic blood pressurewhole bloodInhibitorinhibitorinhibit

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