A11  (Synonyms: ANXA1-derived 11 amino acid-long peptide)

A11 (ANXA1-derived 11 amino acid-long peptide) is a ANXA1-EphA2 interaction-blocking peptide. A11 reduces ANXA1 bound to EphA2 and increases Cbl (the E3 ubiquitin ligase of EphA2) bound to EphA2. A11 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma cells. A11 inhibits angiogenesis. A11 can be used in studies related to nasopharyngeal carcinoma^[1].

A11 (2.5-10 μM; 24 h) blocks the binding of ANXA1 to EphA2, enhances the binding of Cbl to EphA2, reduces the protein level of EphA2 in human nasopharyngeal carcinoma 5-8F and HK1 cells in a dose-dependent manner, and promotes the ubiquitination and endocytosis of EphA2, with the strongest effect observed after 24 h of incubation at the treatment concentration of 10 μM^[1].
A11 (10 μM; 10 days) significantly inhibits the proliferation and anchorage-independent growth of human nasopharyngeal carcinoma 5-8F and HK1 cells^[1].
A11 (10 μM; 24-48 h) significantly inhibits the migration and invasion of human nasopharyngeal carcinoma 5-8F and HK1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A11 (ANXA1-derived 11 amino acid-long peptide) (10 μM; i.p.) significantly inhibits subcutaneous nasopharyngeal carcinoma xenograft growth in nude mice by reducing EphA2 expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2767.16

C₁₁₇H₂₀₄N₄₆O₃₂

2412926-30-6

Solid

White to off-white

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly

YGRKKRRQRRREYVQTVKSSKG

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Feng J, et al. ANXA1 Binds and Stabilizes EphA2 to Promote Nasopharyngeal Carcinoma Growth and Metastasis. Cancer Res. 2020;80(20):4386-4398.  [Content Brief]