A11 acetate  (Synonyms: ANXA1-derived 11 amino acid-long peptide acetate)

A11 (ANXA1-derived 11 amino acid-long peptide) acetate is a ANXA1-EphA2 interaction-blocking peptide. A11 acetate reduces ANXA1 bound to EphA2 and increases Cbl (the E3 ubiquitin ligase of EphA2) bound to EphA2. A11 acetate inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma cells. A11 acetate inhibits angiogenesis. A11 acetate can be used in studies related to nasopharyngeal carcinoma^[1].

A11 (2.5-10 μM; 24 h) acetate blocks the binding of ANXA1 to EphA2, enhances the binding of Cbl to EphA2, reduces the protein level of EphA2 in human nasopharyngeal carcinoma 5-8F and HK1 cells in a dose-dependent manner, and promotes the ubiquitination and endocytosis of EphA2, with the strongest effect observed after 24 h of incubation at the treatment concentration of 10 μM^[1].
A11 (10 μM; 10 days) acetate significantly inhibits the proliferation and anchorage-independent growth of human nasopharyngeal carcinoma 5-8F and HK1 cells^[1].
A11 (10 μM; 24-48 h) acetate significantly inhibits the migration and invasion of human nasopharyngeal carcinoma 5-8F and HK1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A11 (ANXA1-derived 11 amino acid-long peptide) (10 μM; i.p.) acetate significantly inhibits subcutaneous nasopharyngeal carcinoma xenograft growth in nude mice by reducing EphA2 expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2767.16 (free base)

C₁₁₇H₂₀₄N₄₆O₃₂.xC₂H₄O₂

Solid

White to off-white

OC1=CC=C(C=C1)C[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O.[x]

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Feng J, et al. ANXA1 Binds and Stabilizes EphA2 to Promote Nasopharyngeal Carcinoma Growth and Metastasis. Cancer Res. 2020;80(20):4386-4398.  [Content Brief]