ZAP70 - zeta chain of T cell receptor associated protein kinase 70 Gene

Also Known as SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7535

About ZAP70

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:97,713,576-97,756,364 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues, 32 paralogues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 11.2), spleen (RPKM 7.9) and 11 other tissues.

Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ZAP70 Products (3)

mRNA	Protein	Name
NM_001079.4	NP_001070.2	tyrosine-protein kinase ZAP-70 isoform 1
NM_001378594.1	NP_001365523.1	tyrosine-protein kinase ZAP-70 isoform 1
NM_207519.2	NP_997402.1	tyrosine-protein kinase ZAP-70 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	12447358	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7509083	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	15292186	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9489702	GOA
involved in immune response	IDA IDA: Inferred from direct assay	1423621	GOA
acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	22732588	GOA
acts upstream of or within peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	23620790	GOA
acts upstream of or within positive regulation of T cell differentiation	IDA IDA: Inferred from direct assay	7630421	GOA
acts upstream of or within positive thymic T cell selection	IDA IDA: Inferred from direct assay	7630421	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12447358	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of T cell receptor complex	IDA IDA: Inferred from direct assay	8176201	GOA
colocalizes with membrane raft	IDA IDA: Inferred from direct assay	12150984	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12150984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZAP70 Protein Structure

SH2

Pkinase_Tyr

0
100
200
300
400
500
619 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase ZAP-70	70 kDa zeta-associated protein

ZAP70 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ZAP70	P43403	MET	Homo sapiens	P08581	FPS	24728074
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Peptide Array	15832366
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	SPR	9185620
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	ITC	10752619
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Pull Down	8648092
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	SPR	8648092
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Anti Bait CoIP	21957439
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Enzymatic Study	8901551
Intra	ZAP70	P43403	CD247	Homo sapiens	P20963	Pull Down	7528772
Intra	ZAP70	P43403	CD3E	Homo sapiens	P07766	Pull Down	11855827
Intra	ZAP70	P43403	CD3E	Homo sapiens	P07766	SPR	7761456
Intra	ZAP70	P43403	LCK	Homo sapiens	P06239	Far-WB	10556826
Intra	ZAP70	P43403	LCK	Homo sapiens	P06239	Protein Kinase Assay	16461343
Intra	ZAP70	P43403	KIT	Homo sapiens	P10721	FPS	24728074
Intra	ZAP70	P43403	EGFR	Homo sapiens	P00533	Protein Array	16273093
Cross	ZAP70	P43403	Ubash3b	Mus musculus	Q8BGG7	Pull Down	24256567
Cross	ZAP70	P43403	Ubash3b	Mus musculus	Q8BGG7	Anti Tag CoIP	24256567

Cross: Cross-species interaction Intra: Intraspecies interaction

ZAP70 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80524	ZAP70 Antibody (YP4051) (YA003)	WB, ICC/IF, IHC-P, FC, IP	Human
HY-P80937	ZAP70 Antibody (YA651)	WB, IP	Human
HY-P80937A	ZAP70 Antibody (YA651)(PBS only)	WB, IP	Human
HY-P84326	ZAP70 Antibody (YA4023)	WB, IHC-P, ELISA	Human
HY-P84326A	ZAP70 Antibody (YA4023)(PBS only)	WB, IHC-P, ELISA	Human
HY-P84327	ZAP70 Antibody (YA4024)	WB, FC, ELISA	Human
HY-P84327A	ZAP70 Antibody (YA4024)(PBS only)	WB, FC, ELISA	Human
HY-P85592	ZAP70 Antibody (YA5284)	WB, IP	Human
HY-P85831	ZAP70 Antibody (YA5523)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,
HY-P86150	ZAP70 Antibody (YA5842)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86168	Phospho-Zap70(Tyr319)/Syk(Tyr352)Antibody (YA5860)	WB, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Immunodeficiency 48	Combined Immunodeficiency Due To Zap70 Deficiency IMD48 Selective T-Cell Defect Stcd Zeta-Associated-Protein 70 Deficiency Severe Combined Immunodeficiency, Atypical Immunodeficiency, Type 48 Zap70 Deficiency
Autoimmune Disease, Multisystem, Infantile-Onset, 2	ADMIO2 Autoimmune Disease, Multisystem, Infantile-Onset, Type 2
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Zap70-Related Severe Combined Immunodeficiency	Selective T-Cell Defect Zap70-Related Scid Zeta-Associated Protein 70 Deficiency Zap70 Deficiency
Severe Combined Immunodeficiency, Atypical
Combined T And B Cell Immunodeficiency
Prolymphocytic Leukemia	Pll Prolymphocytic Leukaemia Leukemia Prolymphocytic Leukemia, Prolymphocytic
Leukemia, Chronic Lymphocytic 2	Leukemia, Chronic Lymphocytic, Susceptibility To, 2 B-Cell Malignancy, Low-Grade Clls2 Disrupted In B-Cell Malignancy Dbm Leukemia, Chronic Lymphocytic, B-Cell Bcll Lymphocytic Leukemia Chronic B-Cell Chronic Lymphocytic Leukemia Chronic Lymph Leukaemia Chronic Lymphatic Leukaemia Chronic Lymphocytic Leukaemia Chronic Lymphoid Leukaemia Lymphoplasmacytic Leukaemia
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Richter'S Syndrome	Richter Syndrome Richter Transformation
Immunodeficiency 17	IMD17 Cd3-Gamma Deficiency Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive Combined Immunodeficiency Due To Cd3gamma Deficiency Immunodeficiency 17, Cd3 Gamma Deficient Cd3gamma Deficiency Immunodeficiency, Type 17
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
B-Cell Expansion With Nfkb And T-Cell Anergy	Benta Disease BENTA B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease Persistent Polyclonal B-Cell Lymphocytosis Lymphocytosis
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Purine Nucleoside Phosphorylase Deficiency	Purine-Nucleoside Phosphorylase Deficiency Pnp Deficiency Nucleoside Phosphorylase Deficiency Immunodeficiency Due To Purine Nucleoside Phosphorylase Deficiency Deficiency Of Inosine Phosphorylase Pnpase Deficiency PNPD
Chromosomal Triplication	Trisomy
Waldenstroem'S Macroglobulinemia	Waldenstrom Macroglobulinemia Macroglobulinemia Of Waldenstrom Waldenström Macroglobulinemia Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstrom'S Macroglobulinaemia Waldenstrom'S Syndrome Waldenstrom'S Macroglobulinemia Wm Waldenström'S Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	Cll/Sll B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma Icdo:9823/3 Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission Small Cell B-Cell Lymphoma
Immunodeficiency 19	IMD19 Cd3-Delta Deficiency Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Cd3delta Deficiency Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Immunodeficiency 19, Severe Combined Cd3d Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency Immunodeficiency, Type 19
Cd45 Deficiency
Cd40 Ligand Deficiency	X-Linked Hyper Igm Syndrome Hyperimmunoglobulin M Syndrome Higm1 Hyper-Igm Syndrome Type 1 X-Linked Hyper-Igm Syndrome Xhigm Higmx-1 X-Linked Hyper-Igm Immunodeficiency Hyper-Igm Syndrome 1 Immunodeficiency With Hyper-Igm, Type 1 Hyper-Igm Syndrome Due To Cd40 Ligand Deficiency Hyper-Igm Syndrome Due To Cd40l Deficiency Hyper-Igm Immunodeficiency Syndrome Hyper-Igm Immunodeficiency Syndrome, Type 1
Chromosome 13q14 Deletion Syndrome	Chromosome 13q Deletion Syndrome Deletion 13q14 Chromosome 13q Deletion 13q Deletion 13q Monosomy Deletion 13q Monosomy 13q Monosomy 13q14 Del(13)(Q14)
Bare Lymphocyte Syndrome, Type Ii	Mhc Class Ii Deficiency Bare Lymphocyte Syndrome Major Histocompatibility Complex Class Ii Deficiency Bare Lymphocyte Syndrome 2 Bare Lymphocyte Syndrome Type 2 Severe Combined Immunodeficiency, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group C Bare Lymphocyte Syndrome, Type Ii, Complementation Group D Bare Lymphocyte Syndrome Type Ii Scid, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group A Bare Lymphocyte Syndrome, Type Ii, Complementation Group B Scid Due To Absent Class Ii Hla Antigens Hla Class 1 Deficiency Scid, Hla Class 2-Negative Bls Type Ii Bare Lymphocyte Syndrome Type 2, Complementation Group A Bare Lymphocyte Syndrome Type 2, Complementation Group E Severe Combined Immunodeficiency Bls, Type Ii Bls Bare Lymphocyte Syndrome, Type Ii, Complementation Group E Blsii Bls Type 1 Bls 2 Scid Due To Absence Of Class Ii Hla Antigens Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens Immunodeficiency By Defective Expression Of Mhc Class Ii BLS2 Bare Lymphocyte Syndrome Type Ii Complementation Group A Bare Lymphocyte Syndrome Type Ii Complementation Group B Bare Lymphocyte Syndrome Type Ii Complementation Group C Bare Lymphocyte Syndrome Type Ii Complementation Group D Bare Lymphocyte Syndrome Type Ii Complementation Group E Bls Ii Hereditary Mhc Class Ii Deficiency Hla Class Ii Deficient Combined Immunodeficiency Mhc-Ii Deficiency Scid Hla Class Ii-Negative Severe Combined Immunodeficiency Hla Class Ii-Negative Bl-2 Immunodeficiency By Defective Expression Of Hla Class 2 Hla Class 2-Negative Severe Combined Immunodeficiency
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Autoimmune Disease	Autoimmune Diseases Autoimmune Hypersensitivity Disease Hypersensitivity Reaction Type Ii Disease Type Ii Hypersensitivity Reaction Disease
T Cell Deficiency	T Cell Immunodeficiency T Lymphocyte Deficiency T Lymphocyte Immunodeficiency T-Lymphocyte Deficiency
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation	Severe Combined Immunodeficiency, Athabascan Type Severe Combined Immunodeficiency Due To Dclre1c Deficiency Rs-Scid Scid, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive, With Sensitivity To Ionizing Radiation Scid Due To Artemis Deficiency Scid Due To Dclre1c Deficiency Scid, Athabascan Type Scid, Athabaskan Type Severe Combined Immunodeficiency Due To Artemis Deficiency Severe Combined Immunodeficiency, Athabaskan Type SCIDA Severe Combined Immunodeficiency, Athabascan-Type Artemis Deficiency Severe Combined Immunodeficiency Athabaskan Type Severe Combined Immunodeficiency Autosomal Recessive T-Cell-Negative/B-Cell-Negative/Nk-Cell-Positive With Sensitivity To Ionizing Radiation RSSCID Athabascan Scid Immunodeficiency, Severe Combined, Athabascan Type Severe Combined Immunodeficiency, Athabaskan-Type
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis
Peripheral T-Cell Lymphoma	Lymphoma T-Cell Peripheral
Lymphoma, Hodgkin, Classic	Hodgkin Lymphoma Hodgkin Disease Hodgkin'S Lymphoma Hodgkins Lymphoma Classic Hodgkin Lymphoma CHL Hodgkin Lymphoma, Susceptibility To Hl Hodgkin'S Sarcoma Stage I Subdiaphragmatic Hodgkin Lymphoma Stage Ii Subdiaphragmatic Hodgkin Lymphoma Lymphoma, Hodgkin'S Classic Hodgkin Disease Hodgkin'S Disease Lymphoma, Hodgkin, Susceptibility To Hodgkin'S Disease Of Intrapelvic Lymph Nodes Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Malignant Lymphogranuloma Malignant Lymphogranulomatosis Malignant Hodgkin Lymphoma Classical Hodgkin Lymphoma, Type Not Specified
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Anemia, Autoimmune Hemolytic	Autoimmune Hemolytic Anemia Idiopathic Autoimmune Hemolytic Anemia Immuno-Hemolytic Anemia Anemia, Hemolytic, Autoimmune Autoimmune Haemolytic Anaemia Autoimmune Hemolytic Anaemia Acquired Autoimmune Hemolytic Anemia Anemia Hemolytic Autoimmune Familial Auto-Immune Hemolytic Anemia Aha Aiha
Bare Lymphocyte Syndrome, Type I	Hla Class I Deficiency Mhc Class I Deficiency Bls, Type I Bare Lymphocyte Syndrome Type I Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency Blsi Mhc Class 1 Deficiency Major Histocompatibility Complex Class 1 Deficiency Bare Lymphocyte Syndrome 1 BLS1 Bls I Bls Type I Bl-1 Bare Lymphocyte Syndrome Type 1 Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1 Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens Bls - [Bare Lymphocyte Syndrome] Nos
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-112319	(R,S)-MK-8457		/	Phase 2
HY-112319A	MK-8457	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-136179	ZAP-180013	Inhibitor	99.88%	Unkown
HY-155978A	RDN2150 TFA	Inhibitor	99.80%	Unkown
HY-155978	RDN2150	Inhibitor	/	Unkown
HY-123670	RPR-200765A methanesulfonate	Inhibitor	/	Unkown
HY-15322A	(rel)-PRT062607	Inhibitor	/	Unkown
HY-182299	LYP-IN-5		/	Unkown
HY-E70862	Src-ZAP70 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS15951	ZAP70 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-183924	SYK-IN-14	Inhibitor	/	Unkown
HY-RS17310	Zap70 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23765	Zap70 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P99129	Anti-Mouse CD8a Antibody (53-6.7)	Inhibitor	98.18%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZAP70	VGNC	VGNC:37050
Mus musculus	ZAP70	MGD	MGI:99613
Rattus norvegicus	ZAP70	RGD	RGD:3983
Canis familiaris	ZAP70	VGNC	VGNC:54555
Macaca mulatta	ZAP70	VGNC	VGNC:78822
Felis catus	ZAP70	VGNC	VGNC:67158
Others	ZAP70	NCBI