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Cat. No.: HY-182299

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LYP-IN-5

LYP-IN-5 is a lymphoid tyrosine phosphatase (LYP) inhibitor with an IC₅₀ value of 20.6 μM. LYP-IN-5 enhances the phosphorylation of ZAP70 and ERK1/2 following TCR stimulation, and promotes T cell activation. LYP-IN-5 can be used in the research of autoimmune diseases.

For research use only. We do not sell to patients.

CAS No.: 459853-10-2
Formula: C₂₇H₃₆N₆O
Molecular Weight:460.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LYP-IN-5 Chemical Structure

CAS No.: 459853-10-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All ERK Isoforms :

In Vitro

LYP-IN-5 (Compound 4) (50 μM; 30-60 min) enhances the early TCR signaling pathway in JTAg-expressing human T cells and increases the phosphorylation levels of Lck Y394, ZAP70 Y319, ERK1/2, and SLP76 Y128^[1].
LYP-IN-5 (50 μM) enhances TCR-induced phosphorylation of Lck Y394 and LAT Y191 in primary human T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Jurkat T antigen (JTAg) human T cell line
Concentration:

50 μM
Incubation Time:

30-60 min pre-incubation; 2 min TCR stimulation
Result:

Increased TCR-induced phosphorylation of Lck at Y394.
Increased TCR-induced phosphorylation of ZAP70 at Y319.
Increased TCR-induced phosphorylation of ERK1/2.
Increased TCR-induced phosphorylation of SLP76 at Y128.

Chemical Information

CAS No. 459853-10-2
Molecular Weight 460.61
Formula C₂₇H₃₆N₆O
SMILES

O=C1NC2=C(C=C1C(N3CCCC4(CCCCC4)C3)C5=NN=NN5C6CCCC6)C=C(C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stanford SM, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem. 2011;54(6):1640-1654. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
Chemical Information
Purity & Documentation
References

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LYP-IN-5

All ERK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

LYP-IN-5 Related Classifications

HY-182299 Related Classifications