2. Metabolic Enzyme/Protease Stem Cell/Wnt MAPK/ERK Pathway
  3. Phosphatase Tyrosinase ERK
  4. LYP-IN-5

LYP-IN-5 is a lymphoid tyrosine phosphatase (LYP) inhibitor with an IC50 value of 20.6 μM. LYP-IN-5 enhances the phosphorylation of ZAP70 and ERK1/2 following TCR stimulation, and promotes T cell activation. LYP-IN-5 can be used in the research of autoimmune diseases.

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LYP-IN-5

LYP-IN-5 Chemical Structure

CAS No. : 459853-10-2

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LYP-IN-5 Related Antibodies

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Description

LYP-IN-5 is a lymphoid tyrosine phosphatase (LYP) inhibitor with an IC50 value of 20.6 μM. LYP-IN-5 enhances the phosphorylation of ZAP70 and ERK1/2 following TCR stimulation, and promotes T cell activation. LYP-IN-5 can be used in the research of autoimmune diseases[1].

In Vitro

LYP-IN-5 (Compound 4) (50 μM; 30-60 min) enhances the early TCR signaling pathway in JTAg-expressing human T cells and increases the phosphorylation levels of Lck Y394, ZAP70 Y319, ERK1/2, and SLP76 Y128[1].
LYP-IN-5 (50 μM) enhances TCR-induced phosphorylation of Lck Y394 and LAT Y191 in primary human T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LYP-IN-5 Related Antibodies

Western Blot Analysis[1]

Cell Line: Jurkat T antigen (JTAg) human T cell line
Concentration: 50 μM
Incubation Time: 30-60 min pre-incubation; 2 min TCR stimulation
Result: Increased TCR-induced phosphorylation of Lck at Y394.
Increased TCR-induced phosphorylation of ZAP70 at Y319.
Increased TCR-induced phosphorylation of ERK1/2.
Increased TCR-induced phosphorylation of SLP76 at Y128.
Molecular Weight

460.61

Formula

C27H36N6O
CAS No.
SMILES

O=C1NC2=C(C=C1C(N3CCCC4(CCCCC4)C3)C5=NN=NN5C6CCCC6)C=C(C)C=C2
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References
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LYP-IN-5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LYP-IN-5459853-10-2PhosphataseTyrosinaseERKExtracellular signal regulated kinasesJTAg human T cellsprimary T cellsLck Y394HePTPCD45autoimmune diseasesZAP70 Y319Lymphoid Tyrosine PhosphataseLMPTP-APTP-PESTInhibitorinhibitorinhibit

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