Anti-Mouse CD8a Antibody (53-6.7)
Based on 4 publication(s) in Google Scholar
Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice.
For research use only. We do not sell to patients.
- Purity: 98.18%
- Molecular Weight:154 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-Mouse CD8a Antibody (53-6.7)
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Biological Activity
Rat IgG2a kappa
Mouse
CD8a
Anti-Mouse CD8a Antibody (53-6.7) (4-10 μg) inhibits the binding to CD8αα expressing cells up to a maximum of 58% of wild type[1].
Anti-Mouse CD8a Antibody (53-6.7) (1 μg, 30 min) increases CD8αβ-MHC class I tetramer interaction in COS-7 cells[1].
Anti-Mouse CD8a Antibody (53-6.7) (10 μg/mL, 15 min) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo CD8+ T cell depletion; Immunofluorescence; Flow cytometry; Western blot
Chemical Information
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Appearance Liquid
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Molecular Weight 154 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD8a Antibody (53-6.7)]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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J Clin Invest
Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling. [Abstract]2025 Feb 18;135(8):e186648. PMID: 39964752 -
Adv Sci (Weinh)
Materials-Guided Gene-Ionizable Lipid Nanoparticles to Reverse Iron-Associated Immune Resistance in Renal Cancer. [Abstract]2026 Jun 9:e00078. PMID: 42261844 -
Proc Natl Acad Sci U S A
Bioresponsive immunomodulator nanocomplex for selective immunoengineering in metastatic lymph nodes. [Abstract]2026 Jan 27;123(4):e2519625123. PMID: 41557810 -
J Agric Food Chem
Combination of Ginsenoside Compound K and Anti-PD1 Inhibits Pancreatic Cancer by Activating CXCL13-CXCR5 Signaling Axis. [Abstract]2025 Jun 18;73(24):15125-15137. PMID: 40474585
Purity & Documentation
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Data Sheet (262 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Devine L, et al. Location of the epitope for an anti-CD8alpha antibody 53.6.7 which enhances CD8alpha-MHC class I interaction indicates antibody stabilization of a higher affinity CD8 conformation. Immunol Lett. 2004 May 15;93(2-3):123-30. [Content Brief]
[2]. Madi A, et al. CD8 agonism functionally activates memory T cells and enhances antitumor immunity. Int J Cancer. 2022 Sep 1;151(5):797-808. [Content Brief]
[3]. Uddin MN, et al. TNF-α-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma. J Immunol. 2014 Feb 15;192(4):1946-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD8a Antibody (53-6.7) Related Classifications
HY-P99129 Related Classifications
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