Rat IgG2a kappa, Isotype Control

Rat IgG2a kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Jan 23;17(1):952. [Abstract]

Customer Validation
Mouse body weight loss in the passive EAE model, following the transfer of DKO CD4⁺ T cells and treatment with either anti-GM-CSF or Rat IgG2a isotype control (Rat IgG2a kappa, Isotype Control, HY-P990679) (20 mg/kg) (key; n= 5 per group). p value on Day32 was evaluated by unpaired two-tailed Student’s t test.

Rat IgG2a kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Jan 23;17(1):952. [Abstract]

Customer Validation
Flow cytometric analysis of microglia and myeloid cells within the central nervous system (CNS) of passive EAE model mice following adoptive transfer of DKO CD4⁺ T cells and treatment with either an anti-GM-CSF antibody or a rat IgG2a isotype control (Rat IgG2a kappa, Isotype Control, HY-P990679) at a dose of 20 mg/kg.

Rat IgG2a kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Small. 2025 Sep 15:e04715. [Abstract]

Customer Validation
Mouse NSCLC cells LLC were injected into the tail vein of C57BL/6 mice, with saline/IgG (Rat IgG2a kappa, Isotype Control, 200 µg; i.p; once every 3 days for a total of 4 doses) as a control, and separate or combined injection of Anti-PD1 IgG, empty LT-LNPs, nonLT-STING-LNPs, and LT-STING mRNA-LNPs. Isolated lung phenotype showed that both separate injection of Anti-PD1 IgG or LT-STING mRNA-LNPs significantly reduce the number of lung metastases in mice, and combined injection has the most significant inhibitory effect.