Rat IgG2a kappa, Isotype Control

Cat. No.: HY-P990679 Purity: 99.34%: Data Sheet
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Rat IgG2a kappa, Isotype Control is a monoclonal antibody derived from rats, representing the immunoglobulin G2a (IgG2a) subclass with a kappa light chain. Rat IgG2a kappa, Isotype Control exhibits high efficiency in inducing K cell mediated cytotoxicity. Rat IgG2a kappa, Isotype Control is utilized in research investigating the roles of different immunoglobulin subclasses in tumor immunology. Rat IgG2a kappa, an isotype control, can be used as an isotype control for Anti-Mouse PD-1 Antibody (RMP1-14) (HY-P99144), Anti-Mouse CD11a/LFA-1α Antibody (M17/4) (HY-P990801), and Anti-Mouse IL-2 Antibody (S4B6-1) (HY-P990796).

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Based on 3 publication(s) in Google Scholar

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3 Publications Citing Use of MCE Rat IgG2a kappa, Isotype Control

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: Rat IgG2a kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Jan 23;17(1):952. [Abstract]; Mouse body weight loss in the passive EAE model, following the transfer of DKO CD4⁺ T cells and treatment with either anti-GM-CSF or Rat IgG2a isotype control (Rat IgG2a kappa, Isotype Control, HY-P990679) (20 mg/kg) (key; n= 5 per group). p value on Day32 was evaluated by unpaired two-tailed Student’s t test.

: Rat IgG2a kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Jan 23;17(1):952. [Abstract]; Flow cytometric analysis of microglia and myeloid cells within the central nervous system (CNS) of passive EAE model mice following adoptive transfer of DKO CD4⁺ T cells and treatment with either an anti-GM-CSF antibody or a rat IgG2a isotype control (Rat IgG2a kappa, Isotype Control, HY-P990679) at a dose of 20 mg/kg.

: Rat IgG2a kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Small. 2025 Sep 15:e04715. [Abstract]; Mouse NSCLC cells LLC were injected into the tail vein of C57BL/6 mice, with saline/IgG (Rat IgG2a kappa, Isotype Control, 200 µg; i.p; once every 3 days for a total of 4 doses) as a control, and separate or combined injection of Anti-PD1 IgG, empty LT-LNPs, nonLT-STING-LNPs, and LT-STING mRNA-LNPs. Isolated lung phenotype showed that both separate injection of Anti-PD1 IgG or LT-STING mRNA-LNPs significantly reduce the number of lung metastases in mice, and combined injection has the most significant inhibitory effect.

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Description	Rat IgG2a kappa, Isotype Control is a monoclonal antibody derived from rats, representing the immunoglobulin G2a (IgG2a) subclass with a kappa light chain. Rat IgG2a kappa, Isotype Control exhibits high efficiency in inducing K cell mediated cytotoxicity. Rat IgG2a kappa, Isotype Control is utilized in research investigating the roles of different immunoglobulin subclasses in tumor immunology. Rat IgG2a kappa, an isotype control, can be used as an isotype control for Anti-Mouse PD-1 Antibody (RMP1-14) (HY-P99144), Anti-Mouse CD11a/LFA-1α Antibody (M17/4) (HY-P990801), and Anti-Mouse IL-2 Antibody (S4B6-1) (HY-P990796)^[1]^[2].
In Vitro	Rat IgG2a kappa, Isotype Control is a monoclonal antibody derived from rats, representing the immunoglobulin G2a (IgG2a) subclass with a kappa light chain. Rat IgG2a kappa, Isotype Control exhibits high efficiency in inducing K cell mediated cytotoxicity. Rat IgG2a kappa, Isotype Control is utilized in research investigating the roles of different immunoglobulin subclasses in tumor immunology. Rat IgG2a kappa, an isotype control, can be used as an isotype control for Anti-Mouse PD-1 Antibody (RMP1-14) (HY-P99144), Anti-Mouse CD11a/LFA-1α Antibody (M17/4) (HY-P990801), and Anti-Mouse IL-2 Antibody (S4B6-1) (HY-P990796)^[1]^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Rat IgG2a kappa, Isotype Control Related Antibodies
Application	ELISA, FACS, Functional assay
Conjugated	Unconjugated
Reconsititution	The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight	143.93 kDa
Appearance	Liquid
Color	Colorless to light yellow
SMILES	[Rat IgG2a kappa, Isotype Control]
Formulation	Please refer to the lot-specific COA for specific buffer information.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Purity: 99.34% Select Batch: Data Sheet (260 KB) SDS (251 KB) COA (232 KB) SDS-PAGE (136 KB) SEC-HPLC (94 KB) Inhibitory Antibodies User Guide (603 KB)
References	[1]. Chassoux D M, et al. K-cell-mediated cytotoxicity induced with rat monoclonal antibodies. I. Antibodies of various isotypes differ in their ability to induce cytotoxicity mediated by rat and human effectors[J]. Immunology, 1988, 65(4): 623. [Content Brief] [2]. Sun S, et al. Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5-HIAA. J Immunother Cancer. 2025 Sep 10;13(9):e011831. [Content Brief]

Rat IgG2a kappa, Isotype Control Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rat IgG2a kappa, Isotype ControlOthersImmunoglobulinK cellcell toxicitysubtypestumor immunityInhibitorinhibitorinhibit

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Rat IgG2a kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Jan 23;17(1):952. [Abstract]

Customer Validation
Mouse body weight loss in the passive EAE model, following the transfer of DKO CD4⁺ T cells and treatment with either anti-GM-CSF or Rat IgG2a isotype control (Rat IgG2a kappa, Isotype Control, HY-P990679) (20 mg/kg) (key; n= 5 per group). p value on Day32 was evaluated by unpaired two-tailed Student’s t test.
1/16

Rat IgG2a kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2026 Jan 23;17(1):952. [Abstract]

Customer Validation
Flow cytometric analysis of microglia and myeloid cells within the central nervous system (CNS) of passive EAE model mice following adoptive transfer of DKO CD4⁺ T cells and treatment with either an anti-GM-CSF antibody or a rat IgG2a isotype control (Rat IgG2a kappa, Isotype Control, HY-P990679) at a dose of 20 mg/kg.
1/16

Rat IgG2a kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Small. 2025 Sep 15:e04715. [Abstract]

Customer Validation
Mouse NSCLC cells LLC were injected into the tail vein of C57BL/6 mice, with saline/IgG (Rat IgG2a kappa, Isotype Control, 200 µg; i.p; once every 3 days for a total of 4 doses) as a control, and separate or combined injection of Anti-PD1 IgG, empty LT-LNPs, nonLT-STING-LNPs, and LT-STING mRNA-LNPs. Isolated lung phenotype showed that both separate injection of Anti-PD1 IgG or LT-STING mRNA-LNPs significantly reduce the number of lung metastases in mice, and combined injection has the most significant inhibitory effect.
1/16

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