Anti-Mouse CD11a/LFA-1α Antibody (M17/4)
Based on 1 Customer Validation
Anti-Mouse CD11a/LFA-1α Antibody (M17/4) is an anti-mouse CD11a/LFA-1α IgG2a monoclonal antibody. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can reduce the recruitment of effector memory CD8 T cells. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) promotes the formation of xenograft tumors by reducing immune rejection reactions. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can be used for researches on cancer, infection conditions and immunology such as glioblastoma, parasitic and bacterial infections. The recommend isotype control of Anti-Mouse CD11a/LFA-1α Antibody (M17/4): Rat IgG2a kappa, Isotype Control (HY-P990679).
For research use only. We do not sell to patients.
- Purity : 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Isotype
Rat IgG2a kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
CD11a/LFA-1α
In Vivo
Anti-Mouse CD11a/LFA-1α Antibody (M17/4) (20 mg/kg, i.p., on day 0, 2, 4 and 6) promotes the tumorigenicity of human glioblastoma (GBM) cells combined with CD40L mAb (HY-P990134) and CTLA4-Ig in the CD1 mice brain[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Plasmodium berghei ANKA sporozoites infected CB6F1 mice (6-12 weeks) or Listeria monocytogenes strains infected C57BL/6 mice (6-12 weeks)[1]
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Dosage:300 μg
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Administration:Intravenous injection (i.v.), single dose, 3 hours before infection
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Result:Significantly reduced Tem recruitment.
Decreased the ability to clear liver parasites.
Weakened the ability of liver bacteria clearance.
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Animal Model:CD1 mice with an intracranial transplantation of GBM cells model[2]
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Dosage:20 mg/kg
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Administration:Intraperitoneal injection (i.p.), on day 0, 2, 4 and 6
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Result:Promoted successful transplantation of human GBM cells into mouse brain and establish a patient derived xenograft (PDX) model.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo LFA-1 neutralization; Flow cytometry
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD11a/LFA-1a Antibody (M17/4)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Lefebvre MN, et al. Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Rep. 2021 Nov 2;37(5):109956. [Content Brief]
[2]. Bhaduri A, et al. Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 Jan 2;26(1):48-63.e6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD11a/LFA-1α Antibody (M17/4) Related Classifications
HY-P990801 Related Classifications
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