Itgal - integrin alpha L Gene

Also Known as Cd11a; LFA-1; Ly-15; Ly-21; (p180); LFA-1A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16408

Summary

Predicted to enable ICAM-3 receptor activity and cell adhesion molecule binding activity. Involved in cell-cell adhesion. Acts upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell proliferation; and positive regulation of calcium-mediated signaling. Located in cell-cell junction; external side of plasma membrane; and immunological synapse. Is expressed in heart; hemolymphoid system; and vault of skull. Orthologous to human ITGAL (Integrin subunit alpha L). [provided by Alliance of Genome Resources, Apr 2022]

Itgal Products (4)

mRNA Protein Name
NM_001253872.1 NP_001240801.1 integrin alpha-L isoform 1 precursor
NM_001253873.1 NP_001240802.1 integrin alpha-L isoform 3 precursor
NM_001253874.1 NP_001240803.1 integrin alpha-L isoform 4 precursor
NM_008400.3 NP_032426.2 integrin alpha-L isoform 2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
15210787 MGI
acts upstream of calcium-mediated signaling IDA
IDA: Inferred from direct assay
8117278 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
8117278 MGI
involved in cell-cell adhesion IGI
IGI: Inferred from genetic interaction
12652296 MGI
acts upstream of or within leukocyte cell-cell adhesion IDA
IDA: Inferred from direct assay
8117278 MGI
acts upstream of or within leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
8562500 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
1346270 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
8117278 MGI
acts upstream of or within positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
1346270 MGI
acts upstream of or within regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
8117278 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8043862 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
15064761 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin alpha-L

  • CD11 antigen-like family member A

  • alpha L integrin

  • leukocyte adhesion glycoprotein LFA-1 alpha chain

  • leukocyte function-associated molecule 1 alpha chain

  • lymphocyte antigen 15

  • lymphocyte function associated antigen 1, alpha polypeptide

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06959 ITGAL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20429 Itgal Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26938 Itgal Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgal NCBI NCBI:3683