Anti-Mouse PD-1 Antibody (RMP1-14)

Name: Anti-Mouse PD-1 Antibody (RMP1-14)
Brand: MedChemExpress
SKU: HY-P99144
Rating: 5.0 (24 reviews)

Cat. No.: HY-P99144 Purity: 99.63%: Data Sheet
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Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1 IgG2a antibody. Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Free Sample (100 μg)	Apply Now
Free Sample (100 μg)	Apply Now
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 24 publication(s) in Google Scholar

Other Forms of Anti-Mouse PD-1 Antibody (RMP1-14):

Anti-Mouse PD-1 Antibody (S-5001) In-stock

24 Publications Citing Use of MCE Anti-Mouse PD-1 Antibody (RMP1-14)

In Vivo Efficacy Study

RT-PCR

Cell Imaging/Staining

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jan 22;189(2):418-434.e24. [Abstract]; Aslfl/flFoxp3YFP-Cre or littermate Aslwt/wtFoxp3YFP-Cre mice treated with or without Anti-PD-1 antibody (200 μg, i.p.) were subcutaneously inoculated with Hep-53.4 cells (1 × 10⁶), the tumor volume was evaluated every three days. Proportion of Tregs and ammonia levels in the subcutaneous tumors on day 18 were analyzed (n = 6).

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jan 22;189(2):418-434.e24. [Abstract]; Hematoxylin and eosin (H&E) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining evaluated HCC tissues from patients treated with or without PD-1 (200 μg, i.p.) therapy. Elevated tissue ammonia and increased tumor-infiltrating Tregs accordingly.

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 11;23(1):201. [Abstract]; IL-6 and TNF-α levels increased of PFC and serum in MIA offspring mice after PD-1 (1 μg/10⁶ cells, 24 h) Ab alone or PD-1 Ab + MSC-EVs administration.

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 11;23(1):201. [Abstract]; Immunostaining analysis of the level of Iba-1⁺, the microglial soma size, branch number, and total branch length were significantly increased in PD-1 Ab (1 μg/10⁶ cells, 24 h) group.

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 11;23(1):201. [Abstract]; Western blot analysis p-ERK/ERK level elevated in primary microglia after PD-1 (1 μg/10⁶ cells, 24 h) Ab alone or PD-1 Ab + MSC-EVs intervention.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1 IgG2a antibody. Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma^[1].

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

PD-1

In Vivo

Anti-Mouse PD-1 Antibody (RMP1-14) (10 mg/kg, ip, every 3 days for 3-4 doses) exhibits antitumor efficacy in CT26.CL25 subcutaneous tumor model with a complete response rate of 18%, but exhibits no obvious antitumor effect against CT26.CL25 liver metastatic tumor^[1].
Anti-Mouse PD-1 Antibody (RMP1-14) (50-200 μg/mouse, intradermal injection, single dose) induces acute itch in mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mouse CT26.CL25 liver metastasis model^[1]
Dosage:	10 mg/kg
Administration:	ip, every 3 days for 3-4 doses
Result:	Failed to significantly change immune cells when used alone. Increased the M1/M2 ratio, increased the number of mature CD4+ T cells and CD8+ T cells, increased the expression of IFN-γ and TNF-α when used with the combination of CAPOX.

Animal Model:	C57BL/6J mouse models^[2]
Dosage:	50-200 μg/mouse
Administration:	intradermal injection, single dose
Result:	Increased the number of spontaneous scratching in mice.

Gene ID

18566 [NCBI]

Accession

Q02242

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse PD-1 Antibody (RMP1-14)]

Shipping

Shipping with dry ice.

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Biological Activity

Immobilized PD-1 Protein, Mouse (His-Fc, HY-P73724) can bind Anti-Mouse PD-1 Antibody (RMP1-14). The EC₅₀ for this effect is 63.2 ng/mL.

Purity & Documentation

Purity: 99.63%

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Data Sheet (262 KB) SDS (251 KB)

COA (232 KB) SDS-PAGE (91 KB) SEC-HPLC (146 KB)

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Park SJ, et al., Immune modulation of the liver metastatic colorectal cancer microenvironment via the oral CAPOX-mediated cGAS-STING pathway. Biomaterials. 2024 Oct;310:122625. [Content Brief]

[2]. Xu ZH, et al., Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse. Eur J Pharmacol. 2023 Dec 5;960:176128. [Content Brief]