Pdcd1 - programmed cell death 1 Gene

Also Known as PD-1; Pdc1; Ly101

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18566

About Pdcd1

Chromosome 1: 93,966,027-93,980,278 reverse strand.GRCm39:CM000994.3

This gene has 1 transcript (splice variant), 106 orthologues and is associated with 45 phenotypes. Biased expression in thymus adult (RPKM 7.6), ovary adult (RPKM 3.5) and 3 other tissues.

Summary

Involved in negative regulation of immune response. Acts upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdcd1 Products (1)

mRNA Protein Name
NM_008798.3 NP_032824.1 programmed cell death protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15568026 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of B cell apoptotic process IMP
IMP: Inferred from mutant phenotype
23636058 MGI
acts upstream of or within negative regulation of B cell apoptotic process IMP
IMP: Inferred from mutant phenotype
23636058 MGI
involved in negative regulation of immune response IMP
IMP: Inferred from mutant phenotype
10485649 MGI
acts upstream of or within negative regulation of tolerance induction IMP
IMP: Inferred from mutant phenotype
23636058 MGI
acts upstream of or within positive regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
23636058 MGI
acts upstream of regulatory T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
23636058 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15568026 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pdcd1 Protein Structure

IgV_PD1

IgV_PD1: cd16088 (33 - 37)

IgV_PD1

IgV_PD1: cd16088 (33 - 55)

IgV_PD1

IgV_PD1: cd16088 (33 - 144)

IgV_PD1

IgV_PD1: cd16088 (40 - 43)

IgV_PD1

IgV_PD1: cd16088 (47 - 55)

IgV_PD1

IgV_PD1: cd16088 (56 - 62)

IgV_PD1

IgV_PD1: cd16088 (62 - 70)

IgV_PD1

IgV_PD1: cd16088 (63 - 72)

IgV_PD1

IgV_PD1: cd16088 (73 - 82)

IgV_PD1

IgV_PD1: cd16088 (73 - 89)

IgV_PD1

IgV_PD1: cd16088 (85 - 89)

IgV_PD1

IgV_PD1: cd16088 (93 - 127)

IgV_PD1

IgV_PD1: cd16088 (94 - 99)

IgV_PD1

IgV_PD1: cd16088 (104 - 111)

IgV_PD1

IgV_PD1: cd16088 (118 - 128)

IgV_PD1

IgV_PD1: cd16088 (128 - 131)

IgV_PD1

IgV_PD1: cd16088 (130 - 144)

IgV_PD1

IgV_PD1: cd16088 (131 - 144)

  • 0
  • 100
  • 200
  • 288 a.a.
Protein Preferred Names Protein Names

programmed cell death protein 1

  • mPD-1

  • programmed cell death 1 protein

  • protein PD-1

Recombinant Pdcd1 Proteins

Cat. No. Product Name Accession Purity
HY-P70639 PD-1 Protein, Mouse (HEK293, Fc) Q02242 (L25-Q167) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70640 PD-1 Protein, Mouse (HEK293, His) Q02242 (L25-Q167) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73724 PD-1 Protein, Mouse (HEK293, His-Fc) NP_032824.1 (L25-Q167) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700808 PD-1 Protein, Mouse (Biotinylated, HEK293, Fc) Q02242 (L25-Q167) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (11)
Cat. No. Product Name Effect
Purity Phase
HY-P99668 Iparomlimab Inhibitor 96.64% Phase 4
HY-P990074 Enlonstobart Inhibitor 99.27% Phase 3
HY-P990700 Tobemstomig 97.06% Phase 2
HY-P990701 Lomvastomig 99.9% Phase 2
HY-P991698 Liscastobart Inhibitor 98.73% Phase 2
HY-P991345 MEDI-0680 Inhibitor / Phase 2
HY-P991348 BAT-1306 Inhibitor / Phase 2
HY-P990702 Pradusinstobart 97.767% Phase 1
HY-P991346 CC-90006 Inhibitor / Phase 1
HY-P991349 GNR-051 Inhibitor / Phase 1
HY-P991353 Sym-021 Antagonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147273 Fulimetibant Antagonist 99.60% Unkown
HY-RS10185 PDCD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10186 Pdcd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10187 Pdcd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10190 PDCD1LG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18210 Pdcd1lg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24687 Pdcd1lg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990072 Lipustobart Inhibitor 99.9% Unkown
HY-P990722 Danvilostomig 98.38% Unkown
HY-P991113 Abazistobart Inhibitor 96.045% Unkown
HY-P990912 Cugrastomig 98.46% Unkown
HY-P99698 Lesabelimab Inhibitor 97.34% Unkown
HY-P990486 Anti-PDCD1/PD-1/CD279 Antibody Inhibitor / Unkown
HY-P991347 AM0001 Inhibitor / Unkown
HY-P991351 RTX-002 Agonist / Unkown
HY-P992478 TY101 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdcd1 NCBI NCBI:5133