1. Gene
  2. Pdcd1 - programmed cell death 1 Gene

Pdcd1 - programmed cell death 1 Gene

Mus musculus

Also known as PD-1; Pdc1; Ly101

Gene ID: 18566 | Gene type: protein coding

About Pdcd1

Chromosome 1: 93,966,027-93,980,278 reverse strand.GRCm39:CM000994.3

This gene has 1 transcript (splice variant), 106 orthologues and is associated with 45 phenotypes. Biased expression in thymus adult (RPKM 7.6), ovary adult (RPKM 3.5) and 3 other tissues.

Summary

Involved in negative regulation of immune response. Acts upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdcd1 Products(1)

mRNA Protein Name
NM_008798.3 NP_032824.1 programmed cell death protein 1 precursor

Pdcd1 Protein Structure

IgV_PD1

IgV_PD1: cd16088 (33 - 37)

IgV_PD1

IgV_PD1: cd16088 (33 - 55)

IgV_PD1

IgV_PD1: cd16088 (33 - 144)

IgV_PD1

IgV_PD1: cd16088 (40 - 43)

IgV_PD1

IgV_PD1: cd16088 (47 - 55)

IgV_PD1

IgV_PD1: cd16088 (56 - 62)

IgV_PD1

IgV_PD1: cd16088 (62 - 70)

IgV_PD1

IgV_PD1: cd16088 (63 - 72)

IgV_PD1

IgV_PD1: cd16088 (73 - 82)

IgV_PD1

IgV_PD1: cd16088 (73 - 89)

IgV_PD1

IgV_PD1: cd16088 (85 - 89)

IgV_PD1

IgV_PD1: cd16088 (93 - 127)

IgV_PD1

IgV_PD1: cd16088 (94 - 99)

IgV_PD1

IgV_PD1: cd16088 (104 - 111)

IgV_PD1

IgV_PD1: cd16088 (118 - 128)

IgV_PD1

IgV_PD1: cd16088 (128 - 131)

IgV_PD1

IgV_PD1: cd16088 (130 - 144)

IgV_PD1

IgV_PD1: cd16088 (131 - 144)

  • 0
  • 100
  • 200
  • 288 a.a.
Protein Preferred Names Protein Names

programmed cell death protein 1

mPD-1

programmed cell death 1 protein

protein PD-1

Recombinant Pdcd1 Proteins

Cat. No. Product Name Accession Purity
HY-P70639 PD-1 Protein, Mouse (HEK293, Fc) Q02242 (L25-Q167) ≥95%
HY-P70640 PD-1 Protein, Mouse (HEK293, His) Q02242 (L25-Q167) ≥95%
HY-P73724 PD-1 Protein, Mouse (HEK293, His-Fc) NP_032824.1 (L25-Q167) ≥95%
HY-P700808 PD-1 Protein, Mouse (Biotinylated, HEK293, Fc) NP_032824 (L25-Q167) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdcd1 NCBI NCBI:5133
Canis familiaris Pdcd1 NCBI NCBI:486213
Macaca fascicularis Pdcd1 NCBI NCBI:102123659
Rattus norvegicus Pdcd1 NCBI NCBI:301626
Macaca mulatta Pdcd1 NCBI NCBI:100135775