Lomvastomig
Based on 1 Customer Validation
Lomvastomig (RO-7121661) is a PD-1/TIM-3 dual-targeting IgG1 κ monoclonal antibody. Lomvastomig blocks the interaction of PD-1 with PD-L1 and PD-L2. Lomvastomig binds TIM-3 and blocks the interaction of TIM-3 with phosphatidylserine. Lomvastomig can be used in cancer research.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 2648840-52-0
- Molecular Weight:145.335 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
IgG1 - kappa with half-IG VK-CH1/VH-CK crossover
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
PD-1 |
PD-2 |
TIM-3 |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:huPD-1/huTIM-3 double-transgenic knock-in mice (Genoway)[1]
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Dosage:10 mg/kg (i.v. induction); 5 mg/kg (i.p. maintenance every 3 days)
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Administration:i.v. induction; i.p. maintenance every 3 days
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Result:In MC38 tumor-bearing huPD-1/huTIM-3 double-transgenic knock-in mice, 100% of mice controlled tumor growth and 46% experienced complete tumor rejection.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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half-IG-VK-CH1_VH-CK-crossover
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized PD-1 Protein, Human (147a.a, HEK293, His, HY-P70766) can bind Lomvastomig. The EC50 for this effect is 9.648 ng/mL. -
Immobilized TIM-3/HAVCR2 Protein, Human (HEK293, His, HY-P70482) can bind Lomvastomig. The EC50 for this effect is 34.17 ng/mL.
Chemical Information
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CAS No. 2648840-52-0
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Appearance Liquid
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Molecular Weight 145.335 kDa
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Color Colorless to light yellow
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Synonyms
RO-7121661
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)