Cd8a - CD8 antigen, alpha chain Gene

Also Known as Ly-2; Ly-B; Ly-35; Lyt-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12525

Summary

Enables identical protein binding activity. Acts upstream of or within several processes, including cytotoxic T cell differentiation; defense response to virus; and positive regulation of calcium-mediated signaling. Located in external side of plasma membrane. Is expressed in several structures, including endocrine gland; exocrine gland; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CD8a (CD8a molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd8a Products (2)

mRNA Protein Name
NM_001081110.2 NP_001074579.1 T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor
NM_009857.1 NP_033987.1 T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15749886 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7664803 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell mediated immunity IMP
IMP: Inferred from mutant phenotype
1673361 MGI
acts upstream of calcium-mediated signaling IDA
IDA: Inferred from direct assay
9208839 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
9208839 MGI
acts upstream of or within cytotoxic T cell differentiation IMP
IMP: Inferred from mutant phenotype
1673361 MGI
acts upstream of or within defense response to virus IDA
IDA: Inferred from direct assay
17277142 MGI
acts upstream of or within positive regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
9208839 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
14568922 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
1673361 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
22081144 MGI
part of receptor complex IPI
IPI: Inferred from physical interaction
22081144 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell surface glycoprotein CD8 alpha chain

  • Lyt-2.1 lymphocyte differentiation antigen (AA at 100)

  • T-cell surface glycoprotein Lyt-2

Recombinant Cd8a Proteins

Cat. No. Product Name Accession Purity
HY-P74259 CD8A-CD8B Heterodimer Protein, Mouse (HEK293, Flag-His) P01731 (K28-Y196)&P10300 (L22-T175) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74268 CD8 alpha Protein, Mouse (HEK293, His) P01731/NP_001074579.1 (K28-Y196) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74269 CD8 alpha Protein, Mouse (HEK293, Fc) P01731-1 (K28-Y196) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P77520 CD8 alpha Protein, Mouse (Biotinylated, HEK293, His) P01731-1 (K28-Y196) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78898 CD8 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi) P01731-1 (K28-Y196) ≥ 90%, as determined by reducing SDS-PAGE.

Cd8a Antibodies

Cat. No. Product Name Application Reactivity
HY-P89873 CD8-α Antibody (YA9217) IP, ICC/IF, IF-Tissue, IHC-P, FC mouse

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02275 CD8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17486 Cd8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23944 Cd8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99129 Anti-Mouse CD8a Antibody (53-6.7) Inhibitor 98.18% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd8a NCBI NCBI:925