CD8A - CD8a molecule Gene
Also Known as CD8; p32; Leu2; CD8alpha
Species: Homo sapiens
About CD8A
This gene has 8 transcripts (splice variants), 170 orthologues and is associated with 2 phenotypes. Biased expression in spleen (RPKM 38.0), lymph node (RPKM 12.5) and 8 other tissues.
Summary
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]
CD8A Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001145873.1 | NP_001139345.1 | T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor |
| NM_001382698.1 | NP_001369627.1 | T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor |
| NM_001768.7 | NP_001759.3 | T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor |
| NM_171827.4 | NP_741969.1 | T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor |
CD8A Protein Structure
V-set: Immunoglobulin V-set domain (31 - 126)
- 0
- 100
- 200
- 235 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
T-cell surface glycoprotein CD8 alpha chain |
|
Recombinant CD8A Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71662 | CD8 alpha Protein, Human (HEK293, His) | P01732 (S22-D182) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P74270 | CD8 alpha Protein, Human (Biotinylated, CHO, His) | P01732 (S22-D182) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78897 | CD8 alpha Protein, Human (Biotinylated, HEK293, His-Avi) | P01732 (S22-D182) | ≥ 90%, as determined by reducing SDS-PAGE. |
CD8A Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80607 | CD8 alpha Antibody (YA526) | WB, IHC-P | Human, Hamster |
| HY-P80607A | CD8 alpha Antibody (YA526)(PBS only) | WB, IHC-P | Human, Hamster |
| HY-P86616 | CD8 alpha Antibody (YA6308) | WB, IHC-P, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86679 | CD8 alpha Antibody (YA6371) | IHC-P, IHC-F, IF-Tissue | Human |
| HY-P86715 | CD8 alpha Antibody (YA6407) | FC | Human |
| HY-P87176 | CD8 alpha Antibody(YA6867) | WB, IHC-P, IHC-F, ICC/IF | Mouse |
| HY-P89395M | Human CD8 alpha Antibody (PE) (YA6407) | FC | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Cd8 Deficiency, Familial |
|
|
| Herpes Zoster |
|
|
| Lymphoid Interstitial Pneumonia |
|
|
| Diffuse Infiltrative Lymphocytosis Syndrome |
|
|
| Vogt-Koyanagi-Harada Disease |
|
|
| Tracheitis |
|
|
| Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 |
|
|
| Herpes Simplex |
|
|
| Coccidiosis |
|
|
| Hantavirus Hemorrhagic Fever With Renal Syndrome |
|
|
| Lichen Sclerosus Et Atrophicus |
|
|
| Echinococcosis |
|
|
| Alopecia Universalis Congenita |
|
|
| Monkeypox |
|
|
| Peripheral T-Cell Lymphoma |
|
|
| Intestinal Obstruction |
|
|
| Bird Fancier'S Lung |
|
|
| T Cell Deficiency |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Chickenpox |
|
|
| Hypersensitivity Reaction Type Iv Disease |
|
|
| Good Syndrome |
|
|
| Avian Influenza |
|
|
| Lymphoblastic Lymphoma |
|
|
| Temporal Arteritis |
|
|
| Herpangina |
|
|
| Metal Allergy |
|
|
| Thymus Gland Disease |
|
|
| Hilar Lung Neoplasm |
|
|
| Exanthem |
|
|
| Primary Bacterial Infectious Disease |
|
|
| Autoimmune Cholangitis |
|
|
| Acute Retinal Necrosis Syndrome |
|
|
| Primary Cutaneous Gamma-Delta T-Cell Lymphoma |
|
|
| Lichen Disease |
|
|
| West Nile Encephalitis |
|
|
| Pneumocystosis |
|
|
| Fungal Infectious Disease |
|
|
| Thymus Cancer |
|
|
| Fungal Meningitis |
|
|
| Opportunistic Mycosis |
|
|
| Coronavirus Infectious Disease |
|
|
| Lymphocytic Gastritis |
|
|
| Systemic Scleroderma |
|
|
| Genital Herpes |
|
|
| Thymoma |
|
|
| Parapsoriasis |
|
|
| Follicular Mucinosis |
|
|
| T-Cell Adult Acute Lymphocytic Leukemia |
|
|
| Oral Hairy Leukoplakia |
|
|
| Swine Influenza |
|
|
| Chorioretinitis |
|
|
| Bile Duct Cancer |
|
|
| Leukocyte Disease |
|
|
| Critical Covid-19 |
|
|
| West Nile Fever |
|
|
| Lymphocytic Colitis |
|
|
| Epidemic Typhus |
|
|
| Mature T-Cell And Nk-Cell Lymphoma |
|
|
| Cork-Handlers' Disease |
|
|
| Listeriosis |
|
|
| Secondary Syphilis |
|
|
| Ventilation Pneumonitis |
|
|
| B Cell Deficiency |
|
|
| Spongiotic Dermatitis |
|
|
| Severe Covid-19 |
|
|
| Cryptococcal Meningitis |
|
|
| Progressive Multifocal Leukoencephalopathy |
|
|
| Viral Encephalitis |
|
|
| Danubian Endemic Familial Nephropathy |
|
|
| Anus Cancer |
|
|
| Splenic Disease |
|
|
| Granulomatous Hepatitis |
|
|
| Mucocutaneous Leishmaniasis |
|
|
| Integumentary System Disease |
|
|
| Miliary Tuberculosis |
|
|
| Acute Leukemia |
|
|
| Microscopic Colitis |
|
|
| Hepatosplenic T-Cell Lymphoma |
|
|
| Autoimmune Disease Of Blood |
|
|
| Autoimmune Lymphoproliferative Syndrome, Type Iia |
|
|
| Skin Carcinoma |
|
|
| Anogenital Venereal Wart |
|
|
| Esophageal Candidiasis |
|
|
| Neurosarcoidosis |
|
|
| Non-Severe Covid-19 |
|
|
| Adult T-Cell Leukemia/Lymphoma |
|
|
| Mucormycosis |
|
|
| Long Covid |
|
|
| Hemorrhagic Cystitis |
|
|
| Primary Thrombocytopenia |
|
|
| Viral Pneumonia |
|
|
| Autoimmune Disease Of Exocrine System |
|
|
| Autoimmune Disease Of Skin And Connective Tissue |
|
|
| Early Yaws |
|
|
| Extrapulmonary Tuberculosis |
|
|
| Congenital Toxoplasmosis |
|
|
| Necrotic Uveal Melanoma |
|
|
| Primary Systemic Mycosis |
|
|
| Rectal Disease |
|
|
| Autoimmune Myocarditis |
|
|
| Idiopathic Interstitial Pneumonia |
|
|
| Viral Exanthem |
|
|
| Cryptogenic Organizing Pneumonia |
|
|
| Granulomatous Dermatitis |
|
|
| Encephalitozoonosis |
|
|
| Hemangioma Of Spleen |
|
|
| T-Cell Large Granular Lymphocyte Leukemia |
|
|
| Pure Red-Cell Aplasia |
|
|
| Bell'S Palsy |
|
|
| Oral Tuberculosis |
|
|
| Anus Disease |
|
|
| Commensal Bacterial Infectious Disease |
|
|
| Pneumonia |
|
|
| Bare Lymphocyte Syndrome, Type I |
|
|
| Central Nervous System Vasculitis |
|
|
| Salivary Gland Disease |
|
|
| Skin Sarcoidosis |
|
|
| Ebola Hemorrhagic Fever |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Pfeiffer Syndrome |
|
|
| Norwegian Scabies |
|
|
| Hair Disease |
|
|
| Idiopathic Cd4-Positive T-Lymphocytopenia |
|
|
| Autoimmune Glomerulonephritis |
|
|
| Hantavirus Pulmonary Syndrome |
|
|
| Lassa Fever |
|
|
| Conjunctival Disease |
|
|
| Acute Interstitial Pneumonia |
|
|
| Primary Syphilis |
|
|
| Penile Cancer |
|
|
| Anemia, Autoimmune Hemolytic |
|
|
| Parotid Disease |
|
|
| Poliomyelitis |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Cryptococcosis |
|
|
| Tertiary Syphilis |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Immunodeficiency 43 |
|
|
| Adenoid Hypertrophy |
|
|
| Severe Cutaneous Adverse Reaction |
|
|
| Bronchopneumonia |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Lymph Node Disease |
|
|
| Type 1 Diabetes Mellitus 23 |
|
|
| Autoimmune Disease Of Endocrine System |
|
|
| Dengue Hemorrhagic Fever |
|
|
| Human Cytomegalovirus Infection |
|
|
| Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked |
|
|
| Immunodeficiency 13 |
|
|
| Bronchial Disease |
|
|
| Hemophagocytic Lymphohistiocytosis |
|
|
| Mooren'S Ulcer |
|
|
| Superficial Basal Cell Carcinoma |
|
|
| Primary Progressive Multiple Sclerosis |
|
|
| Evans' Syndrome |
|
|
| Orchitis |
|
|
| Autoimmune Disease Of Cardiovascular System |
|
|
| Bacterial Sepsis |
|
|
| Pneumonic Plague |
|
|
| Aggressive Nk-Cell Leukemia |
|
|
| Autoimmune Disease Of Eyes, Ear, Nose And Throat |
|
|
| Immunodeficiency 14 |
|
|
| Disease By Infectious Agent |
|
|
| Tick-Borne Encephalitis |
|
|
| Selective Immunoglobulin Deficiency Disease |
|
|
| Leprosy 3 |
|
|
| Pityriasis Rosea |
|
|
| Polyclonal Hypergammaglobulinemia |
|
|
| Glanders |
|
|
| Listeria Meningitis |
|
|
| Spondyloarthropathy |
|
|
| Farmer'S Lung |
|
|
| Uveal Disease |
|
|
| Collagenous Colitis |
|
|
| Thrombocytopenia Due To Platelet Alloimmunization |
|
|
| Cytomegalovirus Retinitis |
|
|
| Microsporidiosis |
|
|
| Lymphoepithelioma-Like Carcinoma |
|
|
| Autoimmune Uveitis |
|
|
| Parasitic Helminthiasis Infectious Disease |
|
|
| Granulomatous Angiitis |
|
|
| Granulomatous Myositis |
|
|
| Salmonellosis |
|
|
| Aseptic Meningitis |
|
|
| Megaesophagus |
|
|
| Endocervical Carcinoma |
|
|
| Giardiasis |
|
|
| Dysgammaglobulinemia |
|
|
| Bacterial Pneumonia |
|
|
| Duodenitis |
|
|
| Immune-Complex Glomerulonephritis |
|
|
| Aphthous Stomatitis |
|
|
| Lymphoproliferative Syndrome 2 |
|
|
| Cutaneous Leishmaniasis |
|
|
| Extrinsic Allergic Alveolitis |
|
|
| Anterior Uveitis |
|
|
| Nonspecific Interstitial Pneumonia |
|
|
| Tropical Spastic Paraparesis |
|
|
| Wissler-Fanconi Syndrome |
|
|
| Pericardium Disease |
|
|
| Felty Syndrome |
|
|
| Uterine Body Mixed Cancer |
|
|
| Parasitic Ectoparasitic Infectious Disease |
|
|
| Granuloma Annulare |
|
|
| Thymic Dysplasia |
|
|
| Acute Disseminated Encephalomyelitis |
|
|
| Tularemia |
|
|
| Blood Coagulation Disease |
|
|
| Cerebritis |
|
|
| Anal Squamous Cell Carcinoma |
|
|
| Marburg Hemorrhagic Fever |
|
|
| Adult Acute Lymphocytic Leukemia |
|
|
| Transverse Myelitis |
|
|
| Dacryoadenitis |
|
|
| Plague |
|
|
| Facial Nerve Disease |
|
|
| Autoimmune Gastritis |
|
|
| Oral Candidiasis |
|
|
| Combined Immunodeficiency |
|
|
| T-Cell Prolymphocytic Leukemia |
|
|
| Autoimmune Peripheral Neuropathy |
|
|
| Bone Inflammation Disease |
|
|
| Actinic Keratosis |
|
|
| Autoimmune Disease Of Urogenital Tract |
|
|
| Lepromatous Leprosy |
|
|
| Common Cold |
|
|
| Meningoencephalitis |
|
|
| Tuberculoid Leprosy |
|
|
| Contact Dermatitis |
|
|
| Invasive Malignant Thymoma |
|
|
| Paranasal Sinus Disease |
|
|
| Birdshot Chorioretinopathy |
|
|
| Autoimmune Disease Of Peripheral Nervous System |
|
|
| Japanese Encephalitis |
|
|
| Venezuelan Equine Encephalitis |
|
|
| Nose Disease |
|
|
| Multidrug-Resistant Tuberculosis |
|
|
| Suppurative Lymphadenitis |
|
|
| Acute Myocarditis |
|
|
| Factor Xi Deficiency |
|
|
| Panniculitis |
|
|
| Orbital Cellulitis |
|
|
| Acute Orbital Inflammation |
|
|
| Spinal Cord Disease |
|
|
| Dengue Disease |
|
|
| Panuveitis |
|
|
| Dengue Shock Syndrome |
|
|
| Immunodeficiency 16 |
|
|
| Cowpox |
|
|
| Middle Ear Disease |
|
|
| Human Immunodeficiency Virus Infectious Disease |
|
|
| Angioimmunoblastic T-Cell Lymphoma |
|
|
| Capillary Disease |
|
|
| Pneumonic Tularemia |
|
|
| Fallopian Tube Disease |
|
|
| Mast Cell Neoplasm |
|
|
| Abdominal Tuberculosis |
|
|
| Herpes Simplex Virus Keratitis |
|
|
| Uterine Corpus Cancer |
|
|
| Macs Syndrome |
|
|
| Immune System Disease |
|
|
| Gastroduodenitis |
|
|
| Immunoglobulin Alpha Deficiency |
|
|
| Thrombocytopenic Purpura, Autoimmune |
|
|
| Splenic Abscess |
|
|
| Facial Paralysis |
|
|
| Nk Cell Deficiency |
|
|
| Jejunoileitis |
|
|
| Capillary Leak Syndrome |
|
|
| Taeniasis |
|
|
| Middle East Respiratory Syndrome |
|
|
| Iritis |
|
|
| Intestinal Perforation |
|
|
| Paralytic Poliomyelitis |
|
|
| Ulcerative Stomatitis |
|
|
| Urethritis |
|
|
| Parotitis |
|
|
| Visceral Leishmaniasis |
|
|
| Iridocyclitis |
|
|
| Cryptosporidiosis |
|
|
| Rectum Adenocarcinoma |
|
|
| Blood Platelet Disease |
|
|
| Localized Scleroderma |
|
|
| Syphilis |
|
|
| Lung Non-Squamous Non-Small Cell Carcinoma |
|
|
| Tenosynovitis |
|
|
| Cellulitis |
|
|
| Gastrointestinal Tuberculosis |
|
|
| Sezary'S Disease |
|
|
| Immunodeficiency With Hyper-Igm, Type 3 |
|
|
| Chronic Asthma |
|
|
| Borst-Jadassohn Intraepidermal Carcinoma |
|
|
| Lacrimal Apparatus Disease |
|
|
| Xerophthalmia |
|
|
| Human Papillomavirus Infectious Disease |
|
|
| Polyomavirus-Associated Nephropathy |
|
|
| Nasal Cavity Disease |
|
|
| Respiratory Allergy |
|
|
| Scabies |
|
|
| Dermatitis, Atopic |
|
|
| Cervicitis |
|
|
| Allergic Contact Dermatitis |
|
|
| Mite Infestation |
|
|
| Viral Meningitis |
|
|
| Bare Lymphocyte Syndrome, Type Ii |
|
|
| Endocervical Adenocarcinoma |
|
|
| Secondary Progressive Multiple Sclerosis |
|
|
| T-Cell Immunodeficiency With Thymic Aplasia |
|
|
| Alveolar Echinococcosis |
|
|
| Erysipelas |
|
|
| Demyelinating Disease |
|
|
| Acute Proliferative Glomerulonephritis |
|
|
| Crescentic Glomerulonephritis |
|
|
| Pharyngitis |
|
|
| Scleral Disease |
|
|
| Multiple Sclerosis |
|
|
| Vaginal Disease |
|
|
| Bartonellosis |
|
|
| Trypanosomiasis |
|
|
| Short Syndrome |
|
|
| Bone Marrow Cancer |
|
|
| Celiac Disease 1 |
|
|
| Retinitis Pigmentosa 46 |
|
|
| Blepharitis |
|
|
| Autoimmune Lymphoproliferative Syndrome |
|
|
| Sclerosing Cholangitis |
|
|
| Filarial Elephantiasis |
|
|
| Progressive Relapsing Multiple Sclerosis |
|
|
| Pleural Disease |
|
|
| Vaginal Cancer |
|
|
| Colorectal Cancer |
|
|
| Chromophobe Renal Cell Carcinoma |
|
|
| Lymphatic System Disease |
|
|
| Sarcoidosis 1 |
|
|
| Ehrlichiosis |
|
|
| Brain Glioma |
|
|
| Interstitial Nephritis |
|
|
| Spondyloarthropathy 1 |
|
|
| Autoimmune Vasculitis |
|
|
| Inflammatory Bowel Disease |
|
|
| Uterine Carcinosarcoma |
|
|
| Tracheal Disease |
|
|
| Crohn'S Disease |
|
|
| Plasma Protein Metabolism Disease |
|
|
| Gastroesophageal Adenocarcinoma |
|
|
| Monoclonal Gammopathy Of Uncertain Significance |
|
|
| Omenn Syndrome |
|
|
| Pleural Cancer |
|
|
| Chronic Fatigue Syndrome |
|
|
| Mycobacterium Tuberculosis 1 |
|
|
| Lymphatic System Cancer |
|
|
| Oropharynx Cancer |
|
|
| Allergic Disease |
|
|
| Mature B-Cell Neoplasm |
|
|
| Esophageal Cancer |
|
|
| Malaria |
|
|
| Nail Disease |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Demyelinating Polyneuropathy |
|
|
| Bacterial Infectious Disease |
|
|
| Hashimoto Thyroiditis |
|
|
| Ovarian Cystadenocarcinoma |
|
|
| Pancreatic Ductal Carcinoma |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Gingival Disease |
|
|
| Type 1 Diabetes Mellitus 15 |
|
|
| Cranial Nerve Disease |
|
|
| Holoprosencephaly 6 |
|
|
| Scleredema Adultorum |
|
|
| Suppression Of Tumorigenicity 12 |
|
|
| Blood Protein Disease |
|
|
| Keratitis, Hereditary |
|
|
| Adrenal Cortex Disease |
|
|
| Pre-Malignant Neoplasm |
|
|
| Pancytopenia |
|
|
| Potocki-Shaffer Syndrome |
|
|
| Hyper Ige Syndrome |
|
|
| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
|
|
| Melanoma |
|
|
| Thyroid Gland Disease |
|
|
| Corneal Disease |
|
|
| Breast Adenocarcinoma |
|
|
| Toxicodendron Dermatitis |
|
|
| Respiratory Failure |
|
|
| Ovarian Serous Cystadenocarcinoma |
|
|
| Behcet Syndrome |
|
|
| Chronic Mucocutaneous Candidiasis |
|
|
| Testicular Disease |
|
|
| Myeloid And Lymphoid Neoplasms Associated With Fgfr1 Abnormalities |
|
|
| Head And Neck Cancer |
|
|
| Mantle Cell Lymphoma |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Ovary Adenocarcinoma |
|
|
| Epidermodysplasia Verruciformis 1 |
|
|
| Colorectal Adenocarcinoma |
|
|
| Cervix Carcinoma |
|
|
| Skin Disease |
|
|
| Respiratory System Disease |
|
|
| Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency |
|
|
| Hypertension, Essential |
|
|
| Granulomatosis With Polyangiitis |
|
|
| Peripheral Nervous System Disease |
|
|
| Melanoma, Uveal |
|
|
| Beta-Thalassemia Major |
|
|
| Lymphangioma |
|
|
| Colonic Benign Neoplasm |
|
|
| Immunodeficiency 27b |
|
|
| Adrenal Cortical Carcinoma |
|
|
| Severe Combined Immunodeficiency |
|
|
| Immune Deficiency Disease |
|
|
| Optic Nerve Disease |
|
|
| Acute Hemorrhagic Encephalitis |
|
|
| Primary Biliary Cholangitis |
|
|
| Bilirubin Metabolic Disorder |
|
|
| Systemic Lupus Erythematosus |
|
|
| Wilms Tumor 1 |
|
|
| Connective Tissue Disease |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| Deficiency Anemia |
|
|
| Lynch Syndrome |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Aplastic Anemia |
|
|
| Interstitial Lung Disease 2 |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Leukemia, Acute Lymphoblastic |
|
|
| Gliosarcoma |
|
|
| Breast Cancer |
|
|
| Leukemia, Acute Myeloid |
|
|
| Eye Disease |
|
|
| Nervous System Disease |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Myelodysplastic Syndrome |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Myopathy |
|
|
| Dilated Cardiomyopathy |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Congenital Nervous System Abnormality |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | CD8A | VGNC | VGNC:38980 |
| Felis catus | CD8A | VGNC | VGNC:80060 |
| Mus musculus | CD8A | MGD | MGI:88346 |
| Rattus norvegicus | CD8A | RGD | RGD:2316 |
| Bos taurus | CD8A | VGNC | VGNC:27052 |
| Macaca mulatta | CD8A | VGNC | VGNC:70786 |
| Others | CD8A | NCBI |