TLR3 - toll like receptor 3 Gene

Also Known as CD283; IIAE2; IMD83

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7098

About TLR3

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:186,069,156-186,088,073 (from NCBI)

This gene has 9 transcripts (splice variants), 156 orthologues, 22 paralogues and is associated with 3 phenotypes. Ubiquitous expression in duodenum (RPKM 5.4), small intestine (RPKM 5.0) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral Infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021]

TLR3 Products (1)

mRNA	Protein	Name
NM_003265.3	NP_003256.1	toll-like receptor 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	16111635	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18172197	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	16720699	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16858407	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in I-kappaB phosphorylation	IDA IDA: Inferred from direct assay	19740627	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in defense response to virus	IEP IEP: Inferred from expression pattern	32634389	GOA
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	21737330	GOA
involved in inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	GOA
involved in necroptotic signaling pathway	IDA IDA: Inferred from direct assay	21737330	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	27830702	GOA
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23817958	GOA
involved in positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	16286015	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	12054664	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	19740627	GOA
acts upstream of positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	17128265	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19740627	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	16286015	GOA
acts upstream of or within response to exogenous dsRNA	IDA IDA: Inferred from direct assay	21266579	GOA
involved in toll-like receptor 3 signaling pathway	IDA IDA: Inferred from direct assay	17128265	GOA
involved in toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	18172197	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in cell surface	IDA IDA: Inferred from direct assay	19740627	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19740627	GOA
is active in early endosome	IDA IDA: Inferred from direct assay	17982077	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR3 Protein Structure

LRR_8

TIR

0
200
400
600
800
904 a.a.

Protein Preferred Names	Protein Names
toll-like receptor 3

TLR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TLR3	O15455	TLR3	Homo sapiens	O15455	Solution Sedimentation	18172197
Intra	TLR3	O15455	TLR3	Homo sapiens	O15455	ToxCat	23155421
Intra	TLR3	O15455	MBL2	Homo sapiens	P11226	Anti Bait CoIP	24530528
Intra	TLR3	O15455	BLK	Homo sapiens	P51451	Anti Tag CoIP	33961781
Intra	TLR3	O15455	SRC	Homo sapiens	P12931	Anti Tag CoIP	16858407
Intra	TLR3	O15455	CHEK2	Homo sapiens	O96017	Y2H Array	25640309
Intra	TLR3	O15455	CISD2	Homo sapiens	Q8N5K1	Anti Tag CoIP	33961781
Intra	TLR3	O15455	ATP2A3	Homo sapiens	Q93084	Anti Tag CoIP	33961781
Intra	TLR3	O15455	TLR3	Homo sapiens	O15455	NMR	25217833
Intra	TLR3	O15455	TRIL	Homo sapiens	Q7L0X0	Anti Bait CoIP	21911501
Intra	TLR3	O15455	TLR3	Homo sapiens	O15455	GMS	18172197
Intra	TLR3	O15455	UNC93B1	Homo sapiens	Q9H1C4	Anti Tag CoIP	22164301

Cross: Cross-species interaction Intra: Intraspecies interaction

TLR3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80917	Toll-Like Receptor 3 Antibody	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse, Rat
HY-P85635	Toll-Like Receptor 3 Antibody (YA5327)	WB	Transfected

Related Diseases

Diseases	Alias
Bronchiolitis
Common Cold	Acute Coryza Acute Nasopharyngitis Acute Rhinitis Acute Viral Rhinopharyngitis Nasopharyngitis - Acute Nasopharyngitis, Acute Rhino-Sinusitis Rhinosinusitis Common Colds Acute Infective Rhinitis Cold Coryza Head Cold Infective Nasopharyngitis Rhinopharyngitis Acute Nasal Catarrh Infective Rhinitis Acute Nasopharyngeal Catarrh Infective Nasopharyngitis Nos Nasopharyngitis Nos Epipharyngitis Mucositis Nos Inflammatory Disease Of Mucous Membrane Mucosal Inflammation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Genital Herpes	Herpes Genitalis Genital Herpes Simplex Venereal Herpes Virus-Genital Herpes
Paralytic Poliomyelitis	Poliomyelitis, Paralytic
Zika Fever	Zika Virus Infection Zika Virus Disease Zika Virus Zika Virus Fever Mosquito-Borne Viral Fever, Zika
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ehf Ebola Fever Ebola Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Bell'S Palsy	Bell Palsy Facial Nerve Palsy Facial Palsy Facial Paralysis Bell'S Palsy Antoni'S Palsy Facial Cranial Nerve Paralysis Idiopathic Facial Palsy Refrigeration Palsy Facial Nerve Paralysis Seventh Cranial Nerve Paralysis Face Paralysis Nos
Superficial Basal Cell Carcinoma	Multifocal Superficial Basal Cell Carcinoma Multicentric Basal Cell Carcinoma Superficial Multicentric Basal-Cell Carcinoma
Tick-Borne Encephalitis	Siberian Tick-Borne Encephalitis Encephalitis, Tick-Borne Central European Encephalitis Far Eastern Tbe Russian Spring-Summer Encephalitis Taiga Encephalitis West-Siberian Encephalitis Western European Tick-Borne Encephalitis Tbe Encephalitis Tick-Borne Encephalitis, Central European Encephalitis, Far Eastern Russian
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Conjunctivitis	Madras Eye Adenoviral Conjunctivitis Acute Adenoviral Follicular Conjunctivitis Inclusion Conjunctivitis Of The Adult Swimming-Pool Conjunctivitis Inflammation Of Conjunctiva Ophthalmia Acute Conjunctivitis Eye Catarrh Catarrhal Ophthalmia Koch-Weeks Conjunctivitis
Mumps	Parotitis Due To Mumps Virus Mumps Nos Epidemic Parotitis Infectious Parotitis
Avian Influenza	Bird Flu Influenza In Birds Avian Flu
Rosacea	Erythematotelangiectatic Rosacea Papulopustular Rosacea Phymatous Rosacea Acne Roscea Acne, Erythematosa Granulomatous Rosacea Ocular Rosacea Acne Rosacea Hypertrophic Rosacea
Hand, Foot And Mouth Disease	Vesicular Stomatitis And Exanthem
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Subacute Sclerosing Panencephalitis	SSPE Dawson Encephalitis Immunosuppressive Measles Encephalitis Subacute Sclerosing Leukoencephalitis Panencephalitis, Subacute Sclerosing Subacute Sclerosing Leukoencephalopathy Van Bogaert'S Sclerosing Leukoencephalitis Dawson Disease Subacute Inclusion Body Encephalitis Van Bogaert Disease Van Bogaert Encephalitis Measles Inclusion Body Encephalitis Mibe - [Measles Inclusion Body Encephalitis] Sspe - [Subacute Sclerosing Panencephalitis] Van Bogaert Leukoencephalitis Van Bogaert Sclerosing Leukoencephalitis Dawson Inclusion Body Encephalitis Van Bogaert Sclerosing Leukoencephalopathy Bodechtel Guttman Disease Diffuse Sclerosing Encephalitis
West Nile Fever
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Multisystem Inflammatory Syndrome In Children	Mis-C Multisystem Inflammatory Disorder In Children And Adolescents Paediatric Inflammatory Multisystemic Syndrome Mic
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Herpes Simplex Encephalitis	Hse Hsv Encephalitis Hsve Herpes Simplex Meningo-Encephalitis Herpes Simplex Neuroinvasion Herpes Simplex Virus Encephalitis Herpetic Encephalitis Herpes Encephalitis Herpes Simplex Virus 1 Encephalitis
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Hepatitis B	Chronic Hepatitis B Hepatitis B Infection Serum Hepatitis HBV Hepatitis B Chronic Hbv, Susceptibility To Hepatitis B, Chronic Chronic Hepatitis B Without Delta Agent Chronic Hbv - [Hepatitis B Virus] Infection Hepatitis B Nos Chronic Type B Viral Hepatitis Hep B Nos
Poliomyelitis	Infantile Paralysis Polio
Mouth Disease	Mouth Diseases Mouth Disorders
Swine Influenza	Influenza Due To Influenza A Virus Subtype H1n1
Salivary Gland Disease	Salivary Gland Disorders Salivary Gland Diseases Non-Neoplastic Salivary Gland Disease Non-Neoplastic Salivary Gland Disorder Disorder Of Salivary Gland Lesion Of Salivary Gland Nos
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Myocarditis	Myocardial Inflammation Inflammatory Cardiomyopathy
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Chickenpox	Varicella Varicella Nos
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Degeneration Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Primary Bacterial Infectious Disease
Rabies	Lyssa Hydrophobia St Hubert Disease
Bacterial Sepsis
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Herpes Zoster Ophthalmicus	Hzo
Viral Encephalitis	Epidemic Encephalitis Encephalitis Viral Encephalitis, Arbovirus Arbovirus Encephalitis Postviral Encephalitis Nos Equine Encephalitis Tick-Borne Encephalitis Viral Encephalitis Transmitted By Tick Mosquito-Borne Encephalitis Acute Haemorrhagic Encephalitis Acute Idiopathic Encephalitis Chronic Viral Encephalitis Endemic Encephalitis Subacute Viral Encephalitis Viral Haemorrhagic Encephalitis Viral Nonepidemic Encephalitis Nonepidemic Encephalitis
Retinal Vasculitis
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Hepatitis A	Viral Hepatitis A Viral Hepatitis, Type A
Thalamic Neoplasm	Malignant Neoplasm Of Thalamus Malignant Tumor Of Thalamus Tumor Of Thalamus
Hepatitis E
Immunodeficiency 83 Viral Infections	Herpes Simplex Encephalitis, Susceptibility To, 2 IMD83 Immunodeficiency 83, Susceptibility To Viral Infections Encephalopathy, Acute, Infection-Induced, 2 Encephalopathy, Acute, Infection-Induced, 2, Herpes-Specific Herpes Simplex Encephalitis 2 Hse2 Iiae2 Infection-Induced Acute Encephalopathy 2 Tlr3-Deficient Herpes Simplex Encephalitis Encephalitis, Herpes Simplex, Susceptibility To, Type 2
Salmonellosis	Salmonella Infections Salmonella Infection
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Herpes Zoster	Shingles Zoster Herpes Zona Herpes Zoster Disease Zona Zoster Herpes Zoster Of Skin And Mucous Membranes Zoster Nos Zoster With Nervous System Involvement
Mucocutaneous Leishmaniasis	American Cutaneous Leishmaniasis American Mucocutaneous Leishmaniasis Cutaneous Leishmaniasis, American Mucocutaneous Leishmaniasis, American New World Cutaneous Leishmaniasis Leishmaniasis, Mucocutaneous Espundia Leishmania Braziliensis Infection
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Newcastle Disease	Newcastle'S Disease Pseudo-Fowlpest
Coronavirus Infectious Disease
West Nile Encephalitis	West-Nile Encephalitis West Nile Fever West Nile Fever Encephalitis West Nile Fever With Encephalitis West-Nile Fever Encephalitis, West Nile Fever
Diabetes Mellitus	Diabetes
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Tonsillitis	Chronic Tonsillitis Throat Infection - Tonsillitis
Rubella	German Measles Three Day Measles Rubella Nos
X-Linked Immunodeficiency 74	Immunodeficiency 74, Covid-19-Related, X-Linked Imd74 Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection Tlr7 Deficiency X-Linked Immunodeficiency 74,Covid-19-Related
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Anogenital Venereal Wart	Genital Warts Condylomata Acuminata Anogenital Warts Condyloma Acuminatum Anogenital Human Papilloma Virus Infectious Disease Genital Wart Virus Infectious Disease Venereal Wart Venereal Warts Verrucae Anogenitales Verrucae Genitales
Herpangina	Vesicular Pharyngitis
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135748	Polyinosinic-polycytidylic acid sodium	Agonist	99.40%	Unkown
HY-108473	CU-CPT 4a	Inhibitor	99.50%	Unkown
HY-18325	AN-3485	Inhibitor	97.38%	Unkown
HY-135748A	Poly (I:C):Kanamycin (1:1) sodium	Agonist	99.0%	Unkown
HY-101929	CU-CPT17e	Agonist	98.67%	Unkown
HY-114592	M199	Inhibitor	98.55%	Unkown
HY-176192	SMU-14a	Inhibitor	/	Unkown
HY-134958	Polyinosinic-polycytidylic acid potassium	Agonist	/	Unkown
HY-183313	IAV-IN-5	Inhibitor	/	Unkown
HY-183079	ENDO12	Inhibitor	/	Unkown
HY-165632	Creatine ethyl ester	Activator	/	Unkown
HY-W682115	Poly(C)	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TLR3	VGNC	VGNC:51831
Mus musculus	TLR3	MGD	MGI:2156367
Macaca mulatta	TLR3	VGNC	VGNC:78373
Bos taurus	TLR3	VGNC	VGNC:52833
Rattus norvegicus	TLR3	RGD	RGD:735171
Felis catus	TLR3	VGNC	VGNC:66219
Others	TLR3	NCBI