1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)

AN-3485 

Cat. No.: HY-18325
Handling Instructions

AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.

For research use only. We do not sell to patients.

AN-3485 Chemical Structure

AN-3485 Chemical Structure

CAS No. : 1213827-99-6

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.

IC50 & Target

IC50:AN-3485 inhibits TLR2-, TLR3-, TLR4-, and TLR5-mediates TNF-a, IL-1b, and IL-6 release with IC50 values of human PBMCs (103±68 nM, 68±63 nM, 72±33 nM)and isolated monocytes (77±26 nM; 18±6.7 nM; 32±6.5 nM) [1] .

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4540 mL 17.2700 mL 34.5399 mL
5 mM 0.6908 mL 3.4540 mL 6.9080 mL
10 mM 0.3454 mL 1.7270 mL 3.4540 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

289.52

Formula

C₁₄H₁₃BClNO₃

CAS No.

1213827-99-6

SMILES

NCC1=CC(Cl)=C(OC2=CC=C(COB3O)C3=C2)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
AN-3485
Cat. No.:
HY-18325
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AN-3485

Cat. No.: HY-18325