1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. AN-3485

AN-3485 

Cat. No.: HY-18325
Handling Instructions

AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.

For research use only. We do not sell to patients.

AN-3485 Chemical Structure

AN-3485 Chemical Structure

CAS No. : 1213827-99-6

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Description

AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.

IC50 & Target

IC50:AN-3485 inhibits TLR2-, TLR3-, TLR4-, and TLR5-mediates TNF-a, IL-1b, and IL-6 release with IC50 values of human PBMCs (103±68 nM, 68±63 nM, 72±33 nM)and isolated monocytes (77±26 nM; 18±6.7 nM; 32±6.5 nM) [1] .

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

289.52

Formula

C₁₄H₁₃BClNO₃

CAS No.

1213827-99-6

SMILES

NCC1=CC(Cl)=C(OC2=CC=C(COB3O)C3=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

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AN-3485
Cat. No.:
HY-18325
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AN-3485

Cat. No.: HY-18325