Cat. No.: HY-18325

AN-3485

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

AN-3485 is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 also has certain anti-tumor activity.

For research use only. We do not sell to patients.

Purity: 97.38%
CAS No.: 1213827-99-6
Formula: C₁₄H₁₃BClNO₃
Molecular Weight:289.52

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

AN-3485 Chemical Structure

CAS No.: 1213827-99-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

TLR2

TLR3

TLR4

TLR5

IL-1β

IL-6

All Toll-like Receptor (TLR) Isoforms :

All NF-κB Isoforms :

All Interleukin Related Isoforms :

In Vitro

AN-3485 (0-72 h) can inhibit the enhanced cell proliferation, migration, and invasion abilities and suppress the NF-κB signaling pathway in H1975 cells treated with PN1-overexpressing exosomes, indicating that it can weaken the promoting effect of PN1 on the malignant phenotypes of lung cancer cells^[1].
AN-3485 (0-100 μM; 0-24 h) can inhibit the expression and release of TNF-α, IL-1β, and IL-6 mediated by TLR2, TLR3, TLR4, and TLR5 in PBMCs and isolated monocytes (IC₅₀: 18-580 nM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

N-3485 (35 mg/kg; oral administration; twice daily; 20 days) has an ameliorating effect in a Collagen (HY-NP003)-induced murine arthritis model^[2].
AN-3485 (0.1-1 mg; topically applied to the ears; twice) can significantly inhibit PMA (HY-18739)-induced contact dermatitis and Oxazolone (HY-126360)-induced delayed-type hypersensitivity in mice, as well as the production of cytokines such as IL-1β and IL-6^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

DBA/1J male mice aged 6-7 weeks old treated collagen (HY-NP003)^[2]
Dosage:

35 mg/kg
Administration:

Oral administration (p.o.); twice daily for 20 days
Result:

Inhibited the rate of disease progression, and the cumulative disease score increased less compared with the vehicle-treated group.
Alleviated joint inflammation and damage, including synovial inflammation, pannus formation, cartilage damage, and bone resorption.

Chemical Information

CAS No. 1213827-99-6
Appearance Solid
Molecular Weight 289.52
Formula C₁₄H₁₃BClNO₃
Color White to off-white
SMILES

NCC1=CC(Cl)=C(OC2=CC=C(COB3O)C3=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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J Virol

Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice. [Abstract]

2023 Mar 30;97(3):e0000323. PMID: 36877049

Solvent & Solubility

In Vitro:

DMSO : 5 mg/mL (17.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

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Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4540 mL

17.2700 mL

34.5399 mL

5 mM

0.6908 mL

3.4540 mL

6.9080 mL

10 mM

0.3454 mL

1.7270 mL

3.4540 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Y, et al. Cancer-associated Fibroblasts (CAFs) Regulate Lung Cancer Malignant Progression by Transferring SERPINE2 (PN1) Via Exosomes. Curr Mol Med. 2024 Oct 25. [Content Brief]

[2]. Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4540 mL	17.2700 mL	34.5399 mL	86.3498 mL
	5 mM	0.6908 mL	3.4540 mL	6.9080 mL	17.2700 mL
	10 mM	0.3454 mL	1.7270 mL	3.4540 mL	8.6350 mL
	15 mM	0.2303 mL	1.1513 mL	2.3027 mL	5.7567 mL

Keywords

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AN-3485

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Anti-Aging Compound Library

Covalent Screening Library

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Pyroptosis Compound Library

Orally Active Compound Library

Exosomes Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Targeted Diversity Library

Anti-Liver Cancer Compound Library

Antidepressant Compound Library

Anti-Prostate Cancer Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Autoimmune Disease Compound Library

Cytokine Inhibitors Library

Extracellular Vesicles (EVs) Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Bioactive Compound Library

Anti-Fibrosis Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Pattern Recognition Receptors Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) AN-3485

All Toll-like Receptor (TLR) Isoforms

All NF-κB Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

AN-3485 Related Classifications

Cat. No.: HY-18325