1213827-99-6
1213827-99-6
Chemical Structure
AN-3485
- CAS No.: 1213827-99-6
- Formula:C14H13BClNO3
- Molecular Weight:289.52
IUPAC Name: 6-(4-(aminomethyl)-2-chlorophenoxy)benzo[c][1,2]oxaborol-1(3H)-ol
InChIKey: ZBLBFNKPCNPVLW-UHFFFAOYSA-N
SMILES: NCC1=CC(Cl)=C(OC2=CC=C(COB3O)C3=C2)C=C1
Biological Activity: AN-3485 is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 also has certain anti-tumor activity[1][2].
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AN-3485 | 97.38% | AN-3485 is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 also has certain anti-tumor activity. | ||||||||||||||||||||
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References
- [1]. Chen Y, et al. Cancer-associated Fibroblasts (CAFs) Regulate Lung Cancer Malignant Progression by Transferring SERPINE2 (PN1) Via Exosomes. Curr Mol Med. 2024 Oct 25. [Content Brief]
- [2]. Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46. [Content Brief]
