AN-3485 hydrochloride
Based on 1 publication(s) in Google Scholar
AN-3485 hydrochloride is a benzoxaborole analogue and an orally active antagonist of the Toll-like pathway. AN-3485 hydrochloride can inhibit TLR-mediated inflammatory cytokine secretion and has significant anti-inflammatory activity. In addition, AN-3485 hydrochloride also has certain anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 1213786-72-1
- Formula: C14H14BCl2NO3
- Molecular Weight:325.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AN-3485 hydrochloride
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Biological Activity
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TLR2 |
TLR3 |
TLR4 |
TLR5 |
IL-6 |
IL-1β |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
0.052 μM
Compound: 9e
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Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL1-beta release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay
Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL1-beta release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay
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[PMID: 23411072] |
| PBMC | IC50 |
0.067 μM
Compound: 9e
|
Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL6 release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay
Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced IL6 release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay
|
[PMID: 23411072] |
| PBMC | IC50 |
0.083 μM
Compound: 9e
|
Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced TNFalpha release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay
Antiinflammatory activity in human PBMCs assessed as inhibition of LPS-induced TNFalpha release incubated for 15 mins prior to LPS challenge measured after 24 hrs by HTRF assay
|
[PMID: 23411072] |
AN-3485 (0-72 h) hydrochloride can inhibit the enhanced cell proliferation, migration, and invasion abilities and suppress the NF-κB signaling pathway in H1975 cells treated with PN1-overexpressing exosomes, indicating that it can weaken the promoting effect of PN1 on the malignant phenotypes of lung cancer cells[1].
AN-3485 (0-100 μM; 0-24 h) hydrochloride can inhibit the expression and release of TNF-α, IL-1β, and IL-6 mediated by TLR2, TLR3, TLR4, and TLR5 in PBMCs and isolated monocytes (IC50: 18-580 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AN-3485 (0.1-1 mg; topically applied to the ears; twice) hydrochloride can significantly inhibit PMA (HY-18739)-induced contact dermatitis and Oxazolone (HY-126360)-induced delayed-type hypersensitivity in mice, as well as the production of cytokines such as IL-1β and IL-6[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1J male mice aged 6-7 weeks old treated collagen (HY-NP003)[2]
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Dosage:35 mg/kg
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Administration:Oral administration (p.o.); twice daily for 20 days
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Result:Inhibited the rate of disease progression, and the cumulative disease score increased less compared with the vehicle-treated group.
Alleviated joint inflammation and damage, including synovial inflammation, pannus formation, cartilage damage, and bone resorption.
Chemical Information
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CAS No. 1213786-72-1
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Molecular Weight 325.98
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Formula C14H14BCl2NO3
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SMILES
OB1OCC2=CC=C(C=C12)OC3=CC=C(C=C3Cl)CN.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Virol
Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice. [Abstract]2023 Mar 30;97(3):e0000323. PMID: 36877049
Purity & Documentation
References
[1]. Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46. [Content Brief]
[2]. Chen Y, et al. Cancer-associated Fibroblasts (CAFs) Regulate Lung Cancer Malignant Progression by Transferring SERPINE2 (PN1) Via Exosomes. Curr Mol Med. 2024 Oct 25. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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