Poly(C)  (Synonyms: Polycytidylic acid)

Poly(C) (Polycytidylic acid) is a pleiotropic immunostimulant that specifically binds to TLR3, RIG-I and MDA5 receptors. Poly (C) recruits adaptor proteins to activate downstream signaling pathways and induce the production of type I interferons and inflammatory cytokines. Poly (C) triggers cancer cell apoptosis via the intrinsic or extrinsic caspase pathway, thereby exerting inhibitory effects on tumor growth and metastasis. Poly (C) acts as a vaccine adjuvant to modify the tumor microenvironment, regulate the expression of endothelial adhesion molecules and induce virus-like immune responses. Poly (C) can be applied to research related to melanoma, various solid tumors, hematological malignancies and autoimmune insulin-dependent diabetes mellitus^[1][2][3].

Poly (C) (0.15 M NaCl) forms a 1:1 complex with high-molecular-weight polyguanylic acid, and the apparent cooperative dissociation pK of this complex in 0.15 M NaCl is 12.27, indicating that its stability is higher than that of poly G alone^[2].
Poly (C) forms a stable complex with alkali-degraded polyguanylic acid at a nucleotide ratio of 2:1 in a system containing 0.1 M Na⁺Cl⁻, 0.05 M sodium cacodylate, pH 7.0^[2].
Poly (C) undergoes reversible thermal denaturation in a 50% methanol solution containing 0.1 M NaCl and 0.01 M sodium cacodylate at pH 7.0, and dissociates in an 80% methanol solution at 20°C^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(C₉H₁₄N₃O₈P)x

30811-80-4

NC(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O2)=NC1=O.[n]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cheng Y, et al. Anticancer function of polyinosinic-polycytidylic acid[J]. Cancer biology & therapy, 2010, 10(12): 1219-1223.  [Content Brief]

  [2]. Pochon F, et al. Polynucleotides. VI. Interaction between polyguanylic acid and polycytidylic acid[J]. Proceedings of the National Academy of Sciences, 1965, 53(6): 1425-1430.

  [3]. Doukas J, et al. Polyinosinic: polycytidylic acid is a potent activator of endothelial cells[J]. The American journal of pathology, 1994, 145(1): 137.