30811-80-4
Chemical Structure
Poly(C)
Synonym(s): Polycytidylic acid
- CAS No.: 30811-80-4
- Formula:(C9H14N3O8P)x
- Molecular Weight:N/A
IUPAC Name: (5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
SMILES: NC(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O2)=NC1=O.[n]
Biological Activity: Poly(C) (Polycytidylic acid) is a pleiotropic immunostimulant that specifically binds to TLR3, RIG-I and MDA5 receptors. Poly (C) recruits adaptor proteins to activate downstream signaling pathways and induce the production of type I interferons and inflammatory cytokines. Poly (C) triggers cancer cell apoptosis via the intrinsic or extrinsic caspase pathway, thereby exerting inhibitory effects on tumor growth and metastasis. Poly (C) acts as a vaccine adjuvant to modify the tumor microenvironment, regulate the expression of endothelial adhesion molecules and induce virus-like immune responses. Poly (C) can be applied to research related to melanoma, various solid tumors, hematological malignancies and autoimmune insulin-dependent diabetes mellitus[1][2][3].
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Poly(C) | Poly(C) (Polycytidylic acid) is a pleiotropic immunostimulant that specifically binds to TLR3, RIG-I and MDA5 receptors. Poly (C) recruits adaptor proteins to activate downstream signaling pathways and induce the production of type I interferons and inflammatory cytokines. Poly (C) triggers cancer cell apoptosis via the intrinsic or extrinsic caspase pathway, thereby exerting inhibitory effects on tumor growth and metastasis. Poly (C) acts as a vaccine adjuvant to modify the tumor microenvironment, regulate the expression of endothelial adhesion molecules and induce virus-like immune responses. Poly (C) can be applied to research related to melanoma, various solid tumors, hematological malignancies and autoimmune insulin-dependent diabetes mellitus. | |||||||||||||||||||||
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References
- [1]. Cheng Y, et al. Anticancer function of polyinosinic-polycytidylic acid[J]. Cancer biology & therapy, 2010, 10(12): 1219-1223. [Content Brief]
- [2]. Pochon F, et al. Polynucleotides. VI. Interaction between polyguanylic acid and polycytidylic acid[J]. Proceedings of the National Academy of Sciences, 1965, 53(6): 1425-1430.
- [3]. Doukas J, et al. Polyinosinic: polycytidylic acid is a potent activator of endothelial cells[J]. The American journal of pathology, 1994, 145(1): 137.
