1. GPCR/G Protein
    Immunology/Inflammation
  2. Histamine Receptor

Famotidine 

Cat. No.: HY-B0377 Purity: 99.26%
Data Sheet SDS Handling Instructions

Famotidine is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

For research use only. We do not sell to patients.
Famotidine Chemical Structure

Famotidine Chemical Structure

CAS No. : 76824-35-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 106 In-stock
1 g USD 96 In-stock
5 g USD 288 In-stock
10 g   Get quote  
50 g   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Famotidine is a competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion. Target: Histamine H2 Receptor Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and it is commonly used in the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD/GORD). Famotidine Group(2 mg/kg/day) were significantly lower than the equivalent parameters for the Control Group on both the third and seventh days post-surgery. famotidine exerts detrimental effects on the anastomotic bursting pressure and hydroxyproline content of perianastomotic tissues in the colon of rats [1]. famotidine increased the transgastric potential difference (PD) and promoted the recovery of decreased transgastric PD induced by acidified ethanol in rats. The preventive effect of famotidine on gastric lesions is attributable not only to suppression of acid secretion but to activation of the gastric mucosal defensive mechanisms [2].

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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.9634 mL 14.8170 mL 29.6340 mL
5 mM 0.5927 mL 2.9634 mL 5.9268 mL
10 mM 0.2963 mL 1.4817 mL 2.9634 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

337.45

Formula

C₈H₁₅N₇O₂S₃

CAS No.

76824-35-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Famotidine
Cat. No.:
HY-B0377
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