Polyinosinic-polycytidylic acid
Based on 70 publication(s) in Google Scholar
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis.
For research use only. We do not sell to patients.
- Purity: 99.4%
- CAS No.: 24939-03-5
- Formula: (C10H13N4O8P)x.(C9H14N3O8P)x
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Polyinosinic-polycytidylic acid
More- Signal Transduct Target Ther. 2026 Feb 13;11(1):54. [Abstract]
- Signal Transduct Target Ther. 2025 Dec 23;10(1):410. [Abstract]
- Nature. 2025 Jul;643(8072):810-819. [Abstract]
- Imeta. 2026 Feb 24.
- Cell Metab. 2026 May 5;38(5):963-980.e12. [Abstract]
- Immunity. 2025 Sep 9;58(9):2320-2335.e9. [Abstract]
- Nat Cell Biol. 2025 Apr;27(4):683-695. [Abstract]
- J Extracell Vesicles. 2025 May;14(5):e70083. [Abstract]
- Adv Funct Mater. 29 August 2022.
- Autophagy. 2024 Oct;20(10):2133-2145. [Abstract]
- Nat Commun. 2025 Jun 3;16(1):5140. [Abstract]
- Nat Commun. 2025 Feb 24;16(1):1909. [Abstract]
- Hepatology. 2025 Nov 7. [Abstract]
- ACS Nano. 2025 Feb 4;19(4):4195-4212. [Abstract]
- Acta Pharm Sin B. 2025 Oct;15(10):5431-5443. [Abstract]
- J Exp Clin Cancer Res. 2025 Feb 7;44(1):45. [Abstract]
- Adv Sci (Weinh). 2026 Jun 2:e75921. [Abstract]
- Adv Sci (Weinh). 2026 Mar 18:e11012. [Abstract]
- Chem Eng J. 2021 Aug 15:418:129392. [Abstract]
- Biosens Bioelectron. 2026 Oct 15:310:118829. [Abstract]
- J Exp Med. 2026 Apr 6;223(4):e20250344. [Abstract]
- Cell Commun Signal. 2026 Feb 9;24(1):168. [Abstract]
- Mol Ther. 2025 Dec 3;33(12):6146-6159. [Abstract]
- Phytomedicine. 2021 Apr:84:153495. [Abstract]
- Cell Death Discov. 2025 Jul 25;11(1):345. [Abstract]
- J Transl Med. 2025 Nov 10;23(1):1252. [Abstract]
- Mol Ther Oncolytics. 2022 Aug 25:26:413-428. [Abstract]
- Cancer Immunol Res. 2024 Oct 1;12(10):1438-1451. [Abstract]
- Clin Transl Med. 2024 Sep;14(9):e70027. [Abstract]
- Cell Rep. 2026 Apr 3;45(4):117222. [Abstract]
- Cell Rep. 2026 Mar 30;45(4):117179. [Abstract]
- Food Front. 2025 Nov 6.
- Liver Int. 2022 Dec;42(12):2724-2742. [Abstract]
- Nutrients. 2025 Dec 19;18(1):21. [Abstract]
- Int Immunopharmacol. 2026 May 1:176:116468. [Abstract]
- Int Immunopharmacol. 2025 Feb 6:147:114033. [Abstract]
- mBio. 2026 Jun 10;17(6):e0042326. [Abstract]
- Cell Signal. 2025 Aug:132:111807. [Abstract]
- Virol Sin. 2023 Oct;38(5):741-754. [Abstract]
- Virol Sin. 2023 Jun;38(3):335-343. [Abstract]
- J Innate Immun. 2025 Jul 28:1-27. [Abstract]
- Poult Sci. 2026 May 20;105(8):107155. [Abstract]
- FASEB J. 2024 Mar 31;38(6):e23551. [Abstract]
- Fish Shellfish Immunol. 2026 Apr:171:111162. [Abstract]
- Fish Shellfish Immunol. 2026 Feb:169:111053. [Abstract]
- J Virol. 2025 Aug 19;99(8):e0049825. [Abstract]
- Curr Issues Mol Biol. 2025 May 14;47(5):361. [Abstract]
- J Funct Foods. 2026 May 30;142:107364.
- Vet Res. 2025 Nov 5;56(1):210. [Abstract]
- Vet Res. 2024 Sep 27;55(1):115. [Abstract]
- Cancer Med. 2023 Jul;12(14):15676-15690. [Abstract]
- Chem Biol Drug Des. 2025 Nov;106(5):e70196. [Abstract]
- Chem Biol Drug Des. 2023 Nov;102(5):1110-1120. [Abstract]
- Vet Microbiol. 2026 Feb:313:110834. [Abstract]
- Curr Microbiol. 2024 Aug 6;81(9):296. [Abstract]
- Virology. 2026 Sep:622:110980. [Abstract]
- Virology. 2026 Jun:619:110878. [Abstract]
- Transbound Emerg Dis. 2026;2026(1):e5789277. [Abstract]
- World J Tradit Chin Med. 2025 Oct 28.
- Clin Cosmet Investig Dermatol. 2024 May 14:17:1093-1105. [Abstract]
- Biochem Biophys Res Commun. 2024 Apr 16:704:149661. [Abstract]
- Dev Comp Immunol. 2025 Dec:173:105527. [Abstract]
- Dev Comp Immunol. 2025 Sep 29:172:105483. [Abstract]
- Transpl Immunol. 2026 Feb:94:102346. [Abstract]
- Patent. US20250235423A1.
- bioRxiv. 2024 September 23.
- bioRxiv. 2024 Dec 8:2024.12.07.627371. [Abstract]
- Res Sq. 2024 Nov 14.
- SSRN. 2023 Apr 29.
- SSRN. 2021 Apr 26.
Customer Validation & Images
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IP
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RT-PCR
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RT-PCR
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RT-PCR
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Others
Biological Activity
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Bcl-2 |
MDA5 |
RIG-I |
Bax |
IL-17A |
IL-13 |
HSP70 |
Polyinosinic-polycytidylic acid (0.5-5 μg/mL, 3-24 h) induces a dose- and time-dependent increase in paracellular permeability of immortalized airway epithelial cells[4].
Polyinosinic-polycytidylic acid (5 μg/mL, 24 h) does not have cytotoxicity to 16HBE14o- cells[4].
Polyinosinic-polycytidylic acid (5 μg/mL, 6 h) induces disruption of epithelial apical junctional complexes
(AJCs) and tight junctions (TJs) in 16HBE14o- cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:16HBE14o- cells
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Concentration:5 μg/mL
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Incubation Time:24 h
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Result:Did not lead to significant accumulation of LDH in cell-culture medium.
Polyinosinic-polycytidylic acid (10 μg/mouse, Intraperitoneal injection, single dose) decreases lung tumor growth in mice[3].
Polyinosinic-polycytidylic acid (1.25 mg/kg, Intraperitoneal injection, single dose) exerts therapeutic effects against cerebral I/R injury through the downregulation of TLR4/MyD88 signaling via TLR3 in MCAO model mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:lung tumor-bearing mice[3]
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Dosage:10 μg/mouse
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Administration:Intraperitoneal injection (i.p.)
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Result:Induced a significant decrease in the growth of pulmonary metastases in tumor-bearing mice. Reduced the amount of lung foci to ≈ 40%. Significantly increased BAL fluid cell numbers. Increased the level of INF-γ and IL-17A, decreased the levels of IL-13. Increased TLR3 expression.
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Animal Model:Middle cerebral artery occlusion (MCAO) model mice[5]
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Dosage:1.25 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Reduced focal cerebral I/R injury. Increased the expression of Bcl2, Hsp27, and Hsp70, decreased Bax expression, and reduced cellular degeneration and apoptosis. Protected against cerebral ischemia and conferred protection against cerebral I/R injury through the downregulation of TLR4 signaling via TLR3.
Chemical Information
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CAS No. 24939-03-5
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Appearance Solid
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Formula (C10H13N4O8P)x.(C9H14N3O8P)x
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O[C@H](COP(O)(O)=O)[C@H]1O)N2C3=C(C(NC=N3)=O)N=C2.O[C@H]4[C@H](N5C(N=C(N)C=C5)=O)O[C@H](COP(O)(O)=O)[C@H]4O.[x].[x]
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Synonyms
Poly(I:C)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (70)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2026 Feb 13;11(1):54. PMID: 41680122 -
Signal Transduct Target Ther
Oncolytic adenovirus delivery of neoantigens sensitizes low-mutation tumors to anti-PD-1 therapy and prevents metastasis. [Abstract]2025 Dec 23;10(1):410. PMID: 41429778 -
Nature
2025 Jul;643(8072):810-819. PMID: 40369065 -
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Cell Metab
Psoriasis modulates inflammatory bowel disease risk and intestinal epithelium lipid metabolism via IL-1β-producing macrophages. [Abstract]2026 May 5;38(5):963-980.e12. PMID: 41856104 -
Immunity
Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor. [Abstract]2025 Sep 9;58(9):2320-2335.e9. PMID: 40818452 -
Nat Cell Biol
Selective translational control by PABPC1 phase separation regulates blast crisis and therapy resistance in chronic myeloid leukaemia. [Abstract]2025 Apr;27(4):683-695. PMID: 40102686 -
J Extracell Vesicles
Cancer-Specific RNA Modifications in Tumour-Derived Extracellular Vesicles Promote Tumour Growth. [Abstract]2025 May;14(5):e70083. PMID: 40326665 -
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Autophagy
2024 Oct;20(10):2133-2145. PMID: 38762760
Polyinosinic-polycytidylic acid purchased from MedChemExpress. Usage Cited in: Autophagy. 2024 Oct;20(10):2133-2145. [Abstract]
HEK293T cells were transfected with HA-8A or HA-NSs at a dose of 2 μg for 24 h, and then transfected with poly(I:C) for 24 h. Co-IP with HA antibodies and evaluation of LC3, TBK1 and TRIM25 with western blot using IgG as control.
Polyinosinic-polycytidylic acid purchased from MedChemExpress. Usage Cited in: Autophagy. 2024 Oct;20(10):2133-2145. [Abstract]
HEK293T cells were transfected with pCAGGS, HA-NSs and HA-8A, HA-PxxP, HA-DWP, or HA-WxxL at a dose of 2 μg for 24 h, and then transfected with poly(I:C) for 24 h. IFNB and IFIT1 mRNA levels were analyzed with RT-qPCR.
Polyinosinic-polycytidylic acid purchased from MedChemExpress. Usage Cited in: Autophagy. 2024 Oct;20(10):2133-2145. [Abstract]
HeLa cells were transfected with pCAGGS, HA-8A or HA-NSs at a dose of 2 μg for 24 h, and then transfected with poly(I:C) for 24 h. IFNB, IFIT1 and CXCL10 mRNA levels were analyzed with RT-qPCR.
Polyinosinic-polycytidylic acid purchased from MedChemExpress. Usage Cited in: Autophagy. 2024 Oct;20(10):2133-2145. [Abstract]
BECN1 knockout HeLa cells were transfected with pCAGGS, HA-8A or HA-NSs for 24 h, and then transfected with poly(I:C) for 24 h. IFNB, IFIT1 and CXCL10 mRNA levels were analyzed with RT-qPCR.
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Nat Commun
De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS. [Abstract]2025 Jun 3;16(1):5140. PMID: 40461475 -
Nat Commun
Identification of splenic IRF7 as a nanotherapy target for tele-conditioning myocardial reperfusion injury. [Abstract]2025 Feb 24;16(1):1909. PMID: 39994192 -
Hepatology
GPC3-based circular RNA vaccine suppresses hepatocellular carcinoma progression by activating adaptive immune responses. [Abstract]2025 Nov 7. PMID: 41201153 -
ACS Nano
2025 Feb 4;19(4):4195-4212. PMID: 39846120 -
Acta Pharm Sin B
Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy. [Abstract]2025 Oct;15(10):5431-5443. PMID: 41132842 -
J Exp Clin Cancer Res
VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1. [Abstract]2025 Feb 7;44(1):45. PMID: 39920772 -
Adv Sci (Weinh)
NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity. [Abstract]2026 Jun 2:e75921. PMID: 42228052 -
Adv Sci (Weinh)
RNF213 Is an Interferon-Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection. [Abstract]2026 Mar 18:e11012. PMID: 41849692 -
Chem Eng J
Inhalable nanovaccine with biomimetic coronavirus structure to trigger mucosal immunity of respiratory tract against COVID-19. [Abstract]2021 Aug 15:418:129392. PMID: 33762883
Polyinosinic-polycytidylic acid purchased from MedChemExpress. Usage Cited in: Chem Eng J. 2021 Aug 15:418:129392. [Abstract]
Immunofluorescence staining photographs of lung sections. Scale bars, 100 μm. (I: PBS, II: Poly(I:C), III: PL-Poly(I:C), IV: NL-Poly(I:C), V: PL-Poly(I:C)/RBD, VI: NL-Poly(I:C)/RBD).
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Biosens Bioelectron
In situ spatiotemporal tracking of endogenous protein dynamics with allosteric genetically encoded biosensor in living cells. [Abstract]2026 Oct 15:310:118829. PMID: 42184477 -
J Exp Med
Defects in intron recycling suppress the antiviral response via a mechanism of intronic endogenous dsRNA. [Abstract]2026 Apr 6;223(4):e20250344. PMID: 41817448 -
Cell Commun Signal
Grass carp reovirus VP35 hijacks DHX15 into phase-separated inclusion bodies to evade host antiviral immunity. [Abstract]2026 Feb 9;24(1):168. PMID: 41664180 -
Mol Ther
Targeting O-GlcNAcylated METTL3 impedes MDS/AML progression via diminishing SRSF1 m6A modification. [Abstract]2025 Dec 3;33(12):6146-6159. PMID: 40914805 -
Phytomedicine
Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation. [Abstract]2021 Apr:84:153495. PMID: 33611210 -
Cell Death Discov
RIPK1 S213E mutant suppresses RIPK1-dependent cell death by preventing interactions with RIPK3 and CASP8. [Abstract]2025 Jul 25;11(1):345. PMID: 40715038 -
J Transl Med
Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer. [Abstract]2025 Nov 10;23(1):1252. PMID: 41214683 -
Mol Ther Oncolytics
TRIM22 orchestrates the proliferation of GBMs and the benefits of TMZ by coordinating the modification and degradation of RIG-I. [Abstract]2022 Aug 25:26:413-428. PMID: 36159777
Polyinosinic-polycytidylic acid purchased from MedChemExpress. Usage Cited in: Mol Ther Oncolytics. 2022 Aug 25:26:413-428. [Abstract]
Dual-luciferase reporter assay of PPAS (20 ng/ml for 24 h) on CCAR1 promoter in U251MG and 293T cells was performed.
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Cancer Immunol Res
The E3 ubiquitin ligase FBXO38 maintains the antitumor function of natural killer cells by sustaining IL-15R signaling. [Abstract]2024 Oct 1;12(10):1438-1451. PMID: 38990095 -
Clin Transl Med
IBR1, a novel endogenous IFIH1-binding dsRNA, governs IFIH1 activation and M1 macrophage polarisation in ARDS. [Abstract]2024 Sep;14(9):e70027. PMID: 39313944 -
Cell Rep
2026 Apr 3;45(4):117222. PMID: 41934636 -
Cell Rep
4-octyl itaconate inhibits cytokine-mediated inflammation via alkylation of TYK2 and JAK1. [Abstract]2026 Mar 30;45(4):117179. PMID: 41915469 -
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Liver Int
Human poliovirus receptor contributes to biliary atresia pathogenesis by exacerbating natural-killer-cell-mediated bile duct injury. [Abstract]2022 Dec;42(12):2724-2742. PMID: 36251580 -
Nutrients
Aqueous Extract of Fructus Choerospondiatis Peel Suppresses Vascular Inflammation and Alleviates Atherosclerosis via AKT/c-FOS/IL-6 Axis. [Abstract]2025 Dec 19;18(1):21. PMID: 41515139 -
Int Immunopharmacol
Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment. [Abstract]2026 May 1:176:116468. PMID: 41819671 -
Int Immunopharmacol
A VZV-gE subunit vaccine decorated with mPLA elicits protective cellular immmune responses against varicella-zoster virus. [Abstract]2025 Feb 6:147:114033. PMID: 39799738 -
mBio
Lipid droplets and small extracellular vesicles interplay in Japanese encephalitis virus non-lytic release. [Abstract]2026 Jun 10;17(6):e0042326. PMID: 42159429 -
Cell Signal
2025 Aug:132:111807. PMID: 40239727 -
Virol Sin
RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis. [Abstract]2023 Oct;38(5):741-754. PMID: 37633447 -
Virol Sin
Antibiotic-induced gut bacteria depletion has no effect on HBV replication in HBV immune tolerance mouse model. [Abstract]2023 Jun;38(3):335-343. PMID: 37141990 -
J Innate Immun
Impact of ATP Synthase Subunit β on TLR Signaling Pathway in Promoting Airway Remodeling and Heterogeneity of Small Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease. [Abstract]2025 Jul 28:1-27. PMID: 40720940 -
Poult Sci
Duck plague virus US2 promotes p62-mediated autophagic degradation of RIG-I to suppress antiviral signaling. [Abstract]2026 May 20;105(8):107155. PMID: 42190475 -
FASEB J
2024 Mar 31;38(6):e23551. PMID: 38489235 -
Fish Shellfish Immunol
CiLSM14Aa acts as a cytosolic dsRNA sensor to activate antiviral immunity against GCRV-II. [Abstract]2026 Apr:171:111162. PMID: 41611139 -
Fish Shellfish Immunol
Cloning, functional characterization of PfLectin_C, a novel C-type lectin gene in pearl oyster Pinctada fucata, and its roles in immune defense and transplantation immunity. [Abstract]2026 Feb:169:111053. PMID: 41344455 -
J Virol
PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation. [Abstract]2025 Aug 19;99(8):e0049825. PMID: 40631894 -
Curr Issues Mol Biol
2025 May 14;47(5):361. PMID: 40699760 -
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Vet Res
TRIM7 suppresses transmissible gastroenteritis virus replication by targeting the degradation of N protein and activating RIG-I-mediated type I IFN antiviral response. [Abstract]2025 Nov 5;56(1):210. PMID: 41194212 -
Vet Res
2024 Sep 27;55(1):115. PMID: 39334325 -
Cancer Med
Inhibition of FGFR3 upregulates MHC-I and PD-L1 via TLR3/NF-kB pathway in muscle-invasive bladder cancer. [Abstract]2023 Jul;12(14):15676-15690. PMID: 37283287 -
Chem Biol Drug Des
Investigation Into the Inhibition of Ferroptosis by Praeruptorin-A in Sepsis Based on Network Pharmacology. [Abstract]2025 Nov;106(5):e70196. PMID: 41195620 -
Chem Biol Drug Des
Praeruptorin A inhibits the activation of NF-κB pathway and the expressions of inflammatory factors in poly (I:C)-induced RAW264.7 cells. [Abstract]2023 Nov;102(5):1110-1120. PMID: 37500542 -
Vet Microbiol
miR-17195 promotes infectious bronchitis virus proliferation and macrophage-mediated inflammation via the PLCβ2-TAK1 axis. [Abstract]2026 Feb:313:110834. PMID: 41447967 -
Curr Microbiol
Poly I: C Alleviated Duck Intestinal Injury Infected with Duck Viral Enteritis by Inhibiting Apoptosis. [Abstract]2024 Aug 6;81(9):296. PMID: 39105989 -
Virology
Rab4b is associated with inflammatory responses and TLR3-related signaling during Japanese encephalitis virus infection. [Abstract]2026 Sep:622:110980. PMID: 42229201 -
Virology
2026 Jun:619:110878. PMID: 41880901 -
Transbound Emerg Dis
Porcine Rotavirus NSP4 Inhibits Type I Interferon Production via NRBF2-Mediated Autophagic Degradation of MDA-5. [Abstract]2026;2026(1):e5789277. PMID: 42338383 -
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Clin Cosmet Investig Dermatol
Effect of Chloroquine on Type 2 Inflammatory Response in MC903-Induced Atopic Dermatitis Mice. [Abstract]2024 May 14:17:1093-1105. PMID: 38765196 -
Biochem Biophys Res Commun
Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production. [Abstract]2024 Apr 16:704:149661. PMID: 38417343 -
Dev Comp Immunol
Genome-wide analysis unveils the differentiated "external" and "internal" lectin system in the tropical sea cucumber Holothuria leucospilota. [Abstract]2025 Dec:173:105527. PMID: 41274536 -
Dev Comp Immunol
Porcine IFI44L inhibits transmissible gastroenteritis virus (TGEV) replication by activating IFN-Ⅰ signaling pathway. [Abstract]2025 Sep 29:172:105483. PMID: 41033382 -
Transpl Immunol
TLR3 stimulation rejuvenates aged mesenchymal stem cells and restores immunosuppressive function in graft-versus-host disease. [Abstract]2026 Feb:94:102346. PMID: 41520686 -
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bioRxiv
2024 Dec 8:2024.12.07.627371. PMID: 39677789 -
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Solvent & Solubility
H2O : ≥ 10 mg/mL
* "≥" means soluble, but saturation unknown.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: ≥ 10 mg/mL; Clear solution
Purity & Documentation
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Data Sheet (278 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Cheng Y, Xu F. Anticancer function of polyinosinic-polycytidylic acid [J]. Cancer biology & therapy, 2010, 10(12): 1219-1223. [Content Brief]
[2]. Deleidi M, Hallett P J, Koprich J B, et al. The Toll-like receptor-3 agonist polyinosinic: polycytidylic acid triggers nigrostriatal dopaminergic degeneration [J]. Journal of Neuroscience, 2010, 30(48): 16091-16101. [Content Brief]
[3]. Forte G, Rega A, Morello S, et al. Polyinosinic-polycytidylic acid limits tumor outgrowth in a mouse model of metastatic lung cancer [J]. The Journal of Immunology, 2012, 188(11): 5357-5364. [Content Brief]
[4]. Rezaee F, Meednu N, Emo J A, et al. Polyinosinic: polycytidylic acid induces protein kinase D–dependent disassembly of apical junctions and barrier dysfunction in airway epithelial cells [J]. Journal of Allergy and Clinical Immunology, 2011, 128(6): 1216-1224. e11. [Content Brief]
[5]. Wang P F, Fang H, Chen J, et al. Polyinosinic-polycytidylic acid has therapeutic effects against cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via TLR3 [J]. The Journal of Immunology, 2014, 192(10): 4783-4794. [Content Brief]
[6]. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413(6857):732-738. [Content Brief]
[7]. Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun. 2002;293(5):1364-1369. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polyinosinic-polycytidylic acid Related Classifications
HY-107202 Related Classifications
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