1. GPCR/G Protein
  2. Histamine Receptor

Cimetidine (Synonyms: SKF-92334)

Cat. No.: HY-14289 Purity: >98.0%
Handling Instructions

Cimetidine is a histamine-2 (H2) receptor antagonist.

For research use only. We do not sell to patients.

Cimetidine Chemical Structure

Cimetidine Chemical Structure

CAS No. : 51481-61-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 84 In-stock
Estimated Time of Arrival: December 31
10 g USD 126 In-stock
Estimated Time of Arrival: December 31
50 g   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References


Cimetidine is a histamine-2 (H2) receptor antagonist. IC50 Value: Target: Histamine-2 Receptor in vitro: Cimetidine, a partial agonist for H2R, has a pharmacological profile different from ranitidine and famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers [1]. Cimetidine had no effect on the uptake and cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells) [2]. Cimetidine showed no effect on proliferation, survival, migration and invasion of 3LL cells. Cimetidine reversed MDSC-mediated T-cell suppression, and improved IFN-γ production. [3]. Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB, a transcriptional activator of NCAM gene expression [4]. in vivo: the antitumor efficacy of cisplatin in mice bearing luciferase-tagged IGROV-1 xenografts was unaffected by cimetidine (P = 0.39). Data obtained in 18 patients receiving cisplatin (100 mg/m(2)) in a randomized crossover fashion with or without cimetidine (800 mg × 2) revealed that cimetidine did not alter exposure to unbound cisplatin [2]. cimetidine reduced CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen, blood and tumor tissue of tumor-bearing mice [3]. Cimetidine exerts a beneficial effect on periodontal disease in rats, decreasing the RANKL/OPG ratio in gingival connective tissue and reducing alveolar bone resorption [5].

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : 2 mg/mL (7.93 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9629 mL 19.8145 mL 39.6291 mL
5 mM 0.7926 mL 3.9629 mL 7.9258 mL
10 mM 0.3963 mL 1.9815 mL 3.9629 mL
*Please refer to the solubility information to select the appropriate solvent.
Molecular Weight








Powder -20°C 3 years
  4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.


Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Cat. No.: HY-14289