TRIL - TLR4 interactor with leucine rich repeats Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9865

About TRIL

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:28,953,358-28,958,330 (from NCBI)

This gene has 1 transcript (splice variant), 179 orthologues and 22 paralogues.

Summary

TRIL is a component of the TLR4 (MIM 603030) complex and is induced in a number of cell types by lipopolysaccharide (LPS) (Carpenter et al., 2009 [PubMed 19710467]).[supplied by OMIM, Apr 2010]

TRIL Products (1)

mRNA Protein Name
NM_014817.4 NP_055632.2 TLR4 interactor with leucine rich repeats precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
19710467 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
35253622 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of cytokine production involved in immune response IDA
IDA: Inferred from direct assay
19710467 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
19710467 GOA
Cellular Component GO Annotation Evidence References Source
part of lipopolysaccharide receptor complex IDA
IDA: Inferred from direct assay
19710467 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TLR4 interactor with leucine rich repeats

TRIL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRIL Q7L0X0 MLLT11 Homo sapiens Q13015
Anti Bait CoIP
35253622
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15018 TRIL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19966 Tril Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26469 Tril Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRIL MGD MGI:1914123
Canis familiaris TRIL VGNC VGNC:47803
Macaca mulatta TRIL VGNC VGNC:79345
Rattus norvegicus TRIL RGD RGD:1310827
Bos taurus TRIL VGNC VGNC:36311
Others TRIL NCBI