MLLT11 - MLLT11 transcription factor 7 cofactor Gene

Also Known as AF1Q

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10962

About MLLT11

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,060,397-151,069,544 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and is associated with 37 phenotypes. Biased expression in brain (RPKM 95.2), heart (RPKM 17.4) and 3 other tissues.

Summary

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 Amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

MLLT11 Products (1)

mRNA Protein Name
NM_006818.4 NP_006809.1 protein AF1q

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26079538 GOA
Biological Process GO Annotation Evidence References Source
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
18852119 GOA
involved in intrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
18852119 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18852119 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
18852119 GOA
involved in positive regulation of mitochondrial depolarization IDA
IDA: Inferred from direct assay
18852119 GOA
involved in positive regulation of release of cytochrome c from mitochondria IDA
IDA: Inferred from direct assay
18852119 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MLLT11 Protein Structure

WRNPLPNID

WRNPLPNID: Putative WW-binding domain and destruction box (3 - 61)

  • 0
  • 90 a.a.
Protein Preferred Names Protein Names

protein AF1q

  • ALL1 fused gene from chromosome 1q

MLLT11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MLLT11 Q13015 TCF7 Homo sapiens P36402
Anti Bait CoIP
26079538
Intra
MLLT11 Q13015 TCF7 Homo sapiens P36402
Y2H
26079538
Intra
MLLT11 Q13015 S100B Homo sapiens P04271
Anti Tag CoIP
33961781
Intra
MLLT11 Q13015 S100B Homo sapiens P04271
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Myelomonocytic Leukemia

  • Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16

  • 16)(P13

  • Q22)

  • Aml M4

  • Ammol

  • Acute Myeloblastic Leukemia Type 4

  • Aml With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16

  • 16)(P13

  • Q22)

  • Aml-M4

  • Aml With Inv(16)(P13.1q22) Or T(16

  • 16)(P13.1

  • Q22)

  • Cbfb-Myh11

  • Leukemia Myelomonocytic Acute

  • Leukemia, Myelomonocytic, Acute

  • Acute Myelomonocytic Leukaemia Without Mention Of Remission

  • Myelomonocytic Leukaemia Nos
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Childhood Acute Myeloid Leukemia

  • Childhood Acute Myeloid Leukaemia

  • Paediatric Acute Myeloid Leukaemia

  • Pediatric Acute Myeloid Leukemia
Intellectual Developmental Disorder, X-Linked 109

  • Fraxe Syndrome

  • Fragile Xe Syndrome

  • Mental Retardation, X-Linked, Fraxe Type

  • XLID109

  • Mrx109

  • Mental Retardation, X-Linked, Associated With Fragile Site Fraxe

  • Fraxe Mental Retardation Syndrome

  • X-Linked Intellectual Developmental Disorder 109

  • Fraxe Intellectual Disability

  • Fraxe

  • Mental Retardation, X-Linked 109

  • Fragile Site On Chromosome Xq28

  • Fragile Site, Folic Acid Type

  • X-Linked Intellectual Disability Associated With Fragile Site Fraxe

  • Fraxe Intellectual Deficit

  • Intellectual Disability Associated With Fragile Site Fraxe
Childhood Leukemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08495 MLLT11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MLLT11 VGNC VGNC:100011
Canis familiaris MLLT11 VGNC VGNC:43261
Felis catus MLLT11 VGNC VGNC:63525
Rattus norvegicus MLLT11 RGD RGD:1305525
Bos taurus MLLT11 VGNC VGNC:31502
Mus musculus MLLT11 MGD MGI:1929671
Others MLLT11 NCBI