MLLT11 - MLLT11 transcription factor 7 cofactor Gene

Homo sapiens

Also known as AF1Q

Gene ID: 10962 | Gene type: protein coding

About MLLT11

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,060,397-151,069,544 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and is associated with 37 phenotypes. Biased expression in brain (RPKM 95.2), heart (RPKM 17.4) and 3 other tissues.

Summary

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 Amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]

MLLT11 Products(1)

mRNA	Protein	Name
NM_006818.4	NP_006809.1	protein AF1q

MLLT11 Protein Structure

WRNPLPNID

0
90 a.a.

Protein Preferred Names

Protein Names

protein AF1q

ALL1 fused gene from chromosome 1q

Related Diseases

Diseases

Alias

Acute Myelomonocytic Leukemia

Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16	16)(P13
Q22)	Aml M4
Ammol	Acute Myeloblastic Leukemia Type 4
Aml With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16	16)(P13
Q22)	Aml-M4
Aml With Inv(16)(P13.1q22) Or T(16	16)(P13.1
Q22)	Cbfb-Myh11
Leukemia Myelomonocytic Acute	Leukemia, Myelomonocytic, Acute
Acute Myelomonocytic Leukaemia Without Mention Of Remission	Myelomonocytic Leukaemia Nos

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Childhood Acute Myeloid Leukemia

Childhood Acute Myeloid Leukaemia	Paediatric Acute Myeloid Leukaemia
Pediatric Acute Myeloid Leukemia

Intellectual Developmental Disorder, X-Linked 109

Fraxe Syndrome	Fragile Xe Syndrome
Mental Retardation, X-Linked, Fraxe Type	XLID109
Mrx109	Mental Retardation, X-Linked, Associated With Fragile Site Fraxe
Fraxe Mental Retardation Syndrome	X-Linked Intellectual Developmental Disorder 109
Fraxe Intellectual Disability	Fraxe
Mental Retardation, X-Linked 109	Fragile Site On Chromosome Xq28
Fragile Site, Folic Acid Type	X-Linked Intellectual Disability Associated With Fragile Site Fraxe
Fraxe Intellectual Deficit	Intellectual Disability Associated With Fragile Site Fraxe

Childhood Leukemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08495	MLLT11 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MLLT11	VGNC	VGNC:100011
Canis familiaris	MLLT11	VGNC	VGNC:43261
Felis catus	MLLT11	VGNC	VGNC:63525
Rattus norvegicus	MLLT11	RGD	RGD:1305525
Bos taurus	MLLT11	VGNC	VGNC:31502
Mus musculus	MLLT11	MGD	MGI:1929671

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