SIK2 - salt inducible kinase 2 Gene

Homo sapiens

Also known as QIK; SIK-2; SNF1LK2; LOH11CR1I

Gene ID: 23235 | Gene type: protein coding

About SIK2

Cytogenetic location: 11q23.1 Genomic coordinates (GRCh38): 11:111,602,449-111,730,855 (from NCBI)

This gene has 2 transcripts (splice variants), 231 orthologues and 17 paralogues. Ubiquitous expression in fat (RPKM 24.2), brain (RPKM 10.3) and 25 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SIK2 Products(2)

mRNA	Protein	Name
XM_017017417.2	XP_016872906.1	serine/threonine-protein kinase SIK2 isoform X1
NM_015191.3	NP_056006.1	serine/threonine-protein kinase SIK2

SIK2 Protein Structure

Pkinase

0
200
400
600
800
926 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase SIK2

SNF1-like kinase 2	qin-induced kinase
salt-inducible protein kinase 2	salt-inducible serine/threonine kinase 2
serine/threonine-protein kinase SNF1-like kinase 2

Related Diseases

Diseases

Alias

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120856	ARN-3236	Inhibitor	98.60%	Unkown
HY-120877	MRT199665	Inhibitor	99.92%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-148063	DB0614		98.80%	Unkown
HY-139253	MRIA9	Inhibitor	98.34%	Unkown
HY-157442	GLPG3312	Inhibitor	98.25%	Unkown
HY-148061	DB1113		99.28%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SIK2	RGD	RGD:1559698
Canis familiaris	SIK2	VGNC	VGNC:53440
Bos taurus	SIK2	VGNC	VGNC:50078
Felis catus	SIK2	VGNC	VGNC:65143
Mus musculus	SIK2	MGD	MGI:2445031
Macaca mulatta	SIK2	VGNC	VGNC:82237

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