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Cat. No.: HY-184862

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SIK2-IN-5

SIK2-IN-5 is a SIK family kinase inhibitor, with IC₅₀ values of 0.1-1 μM against SIK2 and SIK3, and an IC₅₀ value of >1 μM against SIK1. SIK2-IN-5 inhibits the kinase activities of SIK1, SIK2 and SIK3. SIK2-IN-5 can be used in the research of ovarian cancer and breast cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1613711-28-6
화학식: C₂₃H₂₃F₂N₅O₃S
분자량:487.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SIK2-IN-5 Chemical Structure

CAS No.: 1613711-28-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

SIK1

>1 μM (IC₅₀)

SIK2

0.1-1 μM (IC₅₀)

SIK3

0.1-1 μM (IC₅₀)

All Salt-inducible Kinase (SIK) Isoforms :

In Vitro

SIK2-IN-5 inhibits SIK2 with an IC₅₀ >0.1 μM, SIK1 with an IC₅₀ >1 μM, and SIK3 with an IC₅₀ >0.1 μM in a cell-free kinase assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1613711-28-6
분자량 487.52
화학식 C₂₃H₂₃F₂N₅O₃S
SMILES

O=S(N1CCC(CC1)N2N=CC(C3=CN=C4NC=C(C5=CC(F)=CC(F)=C5OC)C4=C3)=C2)(C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Vankayalapati, H., et al. (2014). Substituted 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors (WO2014093383 A1). World Intellectual Property Organization.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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SIK2-IN-5

All Salt-inducible Kinase (SIK) Isoforms