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Art. -Nr.: HY-184862

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SIK2-IN-5

SIK2-IN-5 is a SIK family kinase inhibitor, with IC₅₀ values of 0.1-1 μM against SIK2 and SIK3, and an IC₅₀ value of >1 μM against SIK1. SIK2-IN-5 inhibits the kinase activities of SIK1, SIK2 and SIK3. SIK2-IN-5 can be used in the research of ovarian cancer and breast cancer.

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CAS. Nr.: 1613711-28-6
Formel: C₂₃H₂₃F₂N₅O₃S
Molecular Weight:487.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SIK2-IN-5 Chemical Structure

CAS. Nr.: 1613711-28-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

SIK1

>1 μM (IC₅₀)

QIK/SIK2

0.1-1 μM (IC₅₀)

QSK/SIK3

0.1-1 μM (IC₅₀)

Alle Salt-inducible Kinase (SIK) Isoform-spezifische Produkte anzeigen :

In Vitro

SIK2-IN-5 inhibits SIK2 with an IC₅₀ >0.1 μM, SIK1 with an IC₅₀ >1 μM, and SIK3 with an IC₅₀ >0.1 μM in a cell-free kinase assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Breast Cancer Modeling

Chemical Information

CAS. Nr. 1613711-28-6
Molecular Weight 487.52
Formel C₂₃H₂₃F₂N₅O₃S
SMILES

O=S(N1CCC(CC1)N2N=CC(C3=CN=C4NC=C(C5=CC(F)=CC(F)=C5OC)C4=C3)=C2)(C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Vankayalapati, H., et al. (2014). Substituted 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors (WO2014093383 A1). World Intellectual Property Organization.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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SIK2-IN-5

Alle Salt-inducible Kinase (SIK) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

SIK2-IN-5 Related Classifications

HY-184862 Related Classifications

Bioz

Keywords

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