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Cat. No.: HY-184862

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SIK2-IN-5

SIK2-IN-5 is a SIK family kinase inhibitor, with IC₅₀ values of 0.1-1 μM against SIK2 and SIK3, and an IC₅₀ value of >1 μM against SIK1. SIK2-IN-5 inhibits the kinase activities of SIK1, SIK2 and SIK3. SIK2-IN-5 can be used in the research of ovarian cancer and breast cancer.

For research use only. We do not sell to patients.

CAS No.: 1613711-28-6
Formula: C₂₃H₂₃F₂N₅O₃S
Molecular Weight:487.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SIK2-IN-5 Chemical Structure

CAS No.: 1613711-28-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

SIK1

>1 μM (IC₅₀)

SIK2

0.1-1 μM (IC₅₀)

SIK3

0.1-1 μM (IC₅₀)

All Salt-inducible Kinase (SIK) Isoforms :

In Vitro

SIK2-IN-5 inhibits SIK2 with an IC₅₀ >0.1 μM, SIK1 with an IC₅₀ >1 μM, and SIK3 with an IC₅₀ >0.1 μM in a cell-free kinase assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1613711-28-6
Molecular Weight 487.52
Formula C₂₃H₂₃F₂N₅O₃S
SMILES

O=S(N1CCC(CC1)N2N=CC(C3=CN=C4NC=C(C5=CC(F)=CC(F)=C5OC)C4=C3)=C2)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vankayalapati, H., et al. (2014). Substituted 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors (WO2014093383 A1). World Intellectual Property Organization.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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SIK2-IN-5

All Salt-inducible Kinase (SIK) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SIK2-IN-5 Related Classifications

HY-184862 Related Classifications