1. Immunology/Inflammation
    Cytoskeleton
    Cell Cycle/DNA Damage
    Apoptosis
  2. Salt-inducible Kinase (SIK)
    PAK
    Apoptosis
  3. MRIA9

MRIA9 

Cat. No.: HY-139253
Handling Instructions

MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively.

For research use only. We do not sell to patients.

MRIA9 Chemical Structure

MRIA9 Chemical Structure

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Description

MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively[1].

In Vitro

MRIA9 (5 μM) MRIA9 sensitizes SKOV3 cells to paclitaxel treatment through inducing pronounced apoptosis[1].
MRIA9 (5 μM) with paclitaxel (2 nM) significantly enhances cell death in HeLa cells[1].
MRIA9 strongly impedes centrosome function, causes mitotic spindle mispositioning in ovarian cancer cell lines, prevents the centrosome disjunction during the late G2 phase, and sensitized ovarian cancer cells and patient derived 3D-spheroids to paclitaxel treatment[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SKOV3 cells.
Concentration: 0.5-5 μM (1 nM paclitaxel).
Incubation Time: 9 days.
Result: Inhibited cell growth.
In Vivo

MRIA9 shows high oral bioavailability (F = 75-80%)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

496.92

Formula

C₂₄H₂₂ClFN₆O₃

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
MRIA9
Cat. No.:
HY-139253
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