- Recombinant Proteins
- Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
- VEGF & VEGFR Receptor Tyrosine Kinases Protein Tyrosine Kinases
- VEGFR
- VEGFR-1
VEGFR-1
VEGFR-1, also known as Flt-1, is the highest-affinity receptor for VEGF-A and additionally binds VEGF-B and placental growth factor (PlGF). Despite its ligand affinity, its intrinsic kinase signaling is weak; instead VEGFR-1 largely modulates angiogenesis by sequestering VEGF-A away from VEGFR-2 and by recruiting monocytes and hematopoietic progenitors. A naturally secreted splice variant, sFlt-1, acts as a soluble decoy, and its excess is central to the pathogenesis of preeclampsia. VEGFR-1 also contributes to pathological neovascularization and tumor angiogenesis. Recombinant VEGFR-1 proteins are standard reagents for VEGF-family binding studies and anti-angiogenic antibody characterization.
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VEGFR-1 Recombinant Proteins (10)
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Inhibitors & Agonists (76)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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