LAT - linker for activation of T cells Gene

Also Known as LAT1; pp36; IMD52

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27040

About LAT

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,984,803-28,990,784 (from NCBI)

This gene has 16 transcripts (splice variants), 87 orthologues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 29.3), appendix (RPKM 13.0) and 19 other tissues.

Summary

The protein encoded by this gene is phosphorylated by ZAP-70/Syk Protein Tyrosine Kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LAT Products (4)

mRNA Protein Name
NM_001014987.2 NP_001014987.1 linker for activation of T-cells family member 1 isoform b
NM_001014988.2 NP_001014988.1 linker for activation of T-cells family member 1 isoform c
NM_001014989.2 NP_001014989.2 linker for activation of T-cells family member 1 isoform d
NM_014387.4 NP_055202.1 linker for activation of T-cells family member 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
33080222 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9489702 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12186560 GOA
enables signaling receptor complex adaptor activity IDA
IDA: Inferred from direct assay
9489702 GOA
Biological Process GO Annotation Evidence References Source
involved in Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
12646565 GOA
involved in T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
25907557 GOA
involved in calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
12646565 GOA
involved in immune response IDA
IDA: Inferred from direct assay
15100278 GOA
involved in integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
15100278 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12646565 GOA
involved in membrane raft distribution IDA
IDA: Inferred from direct assay
33080222 GOA
involved in positive regulation of protein kinase activity IEP
IEP: Inferred from expression pattern
14624253 GOA
involved in regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
12646565 GOA
Cellular Component GO Annotation Evidence References Source
part of TCR signalosome IDA
IDA: Inferred from direct assay
33080222 GOA
located in immunological synapse IDA
IDA: Inferred from direct assay
12646565 GOA
located in membrane IDA
IDA: Inferred from direct assay
12646565 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
9729044 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAT Protein Structure

LAT

LAT: Linker for activation of T-cells (1 - 260)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

linker for activation of T-cells family member 1

  • 36 kDa phospho-tyrosine adapter protein

LAT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LAT O43561 LCK Homo sapiens P06239
Anti Bait CoIP
16938345
Intra
LAT O43561 EGFR Homo sapiens P00533
Ub Reconstruction
31980649
Intra
LAT O43561 EGFR Homo sapiens P00533
Lumier
24658140
Intra
LAT O43561 SGTA Homo sapiens O43765
Validated Y2H
25416956
Intra
LAT O43561 SGTA Homo sapiens O43765
Y2H Array
25416956
Intra
LAT O43561 GRB2 Homo sapiens P62993
Pull Down
10811803
Intra
LAT O43561 GRB2 Homo sapiens P62993
CoIP
10811803
Intra
LAT O43561 GRB2 Homo sapiens P62993
CoIP
9489702
Intra
LAT O43561 PLCG1 Homo sapiens P19174
Anti Bait CoIP
16938345
Intra
LAT O43561 PLCG1 Homo sapiens P19174
CoIP
10811803
Intra
LAT O43561 PIK3R1 Homo sapiens P27986
Pull Down
10811803
Intra
LAT O43561 PIK3R1 Homo sapiens P27986
CoIP
10811803
Intra
LAT O43561 PTPN1 Homo sapiens P18031
Pull Down
12857726
Intra
LAT O43561 PTPN1 Homo sapiens P18031
Phosphatase Assay
12857726
Cross: Cross-species interaction Intra: Intraspecies interaction

LAT Antibodies

Cat. No. Product Name Application Reactivity
HY-P81297 Phospho-LAT (Tyr191) Antibody (YA1021) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P81297A Phospho-LAT (Tyr200) Antibody (YA1022) WB Human
HY-P81297AA Phospho-LAT (Tyr200) Antibody (YA1022)(PBS only) WB Human
HY-P83416 LAT Antibody (YA3161) WB, IHC-P, IP Human
HY-P83416A LAT Antibody (YA3161)(PBS only) WB, IHC-P, IP Human

Related Diseases

Diseases Alias
Immunodeficiency 52

  • Severe Combined Immunodeficiency Due To Lat Deficiency

  • IMD52

  • Scid Due To Lat Deficiency

  • Immunodeficiency, Type 52
Combined Immunodeficiency

  • Combined T Cell And B Cell Immunodeficiency

  • Congenital Combined Immunodeficiency

  • Syndrome With Combined Immunodeficiency

  • Combined T And B Cell Immunodeficiency

  • Combined Immunity Deficiency

  • Combined Immunodeficiency Syndrome

  • Combined T-Cell And B-Cell Immunodeficiency

  • Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency

  • Scid

  • Severe Combined Immunodeficiency Disease

  • Combined T And B Cell Inborn Immunodeficiency

  • Immunodeficiency, Severe Combined

  • Scid - [Severe Combined Immunodeficiencies]
Lymphopenia

  • Lymphocytopenia
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14889 Fluciclovine / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16929 Latrunculin A Inhibitor 98.9% Phase 4

Pre-clinical Phase

Bioactive Molecules (45)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138489 TRULI Inhibitor 99.98% Unkown
HY-150042 TDI-011536 Inhibitor 99.91% Unkown
HY-108540 BCH Inducer 99.83% Unkown
HY-160769 NIBR-LTSi 99.97% Unkown
HY-147082 GA-017 98.95% Unkown
HY-W011391 GPNA hydrochloride 99.91% Unkown
HY-W087830 L-p-Boronophenylalanine 99.84% Unkown
HY-120139 KMH-233 Inhibitor 99.75% Unkown
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-N8847 α-Ionone 94.30% Unkown
HY-130504 Propargyl-PEG1-acid 97.0% Unkown
HY-155978A RDN2150 TFA Inhibitor 99.80% Unkown
HY-176886 LATS-IN-2 Inhibitor 99.45% Unkown
HY-164254 Cardiomyocyte proliferation promoting agent-1 Inhibitor 99.87% Unkown
HY-N3999 Venuloside A 99.82% Unkown
HY-175247 DDO-4033 99.11% Unkown
HY-W267524 H-Phe(3-CF3)-OH / Unkown
HY-120139A (R)-KMH-233 Control / Unkown
HY-183513 L-Ala-BPA Substrate / Unkown
HY-RS07538 LATS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-108540R BCH (Standard) Inducer 99.84% Unkown
HY-127042 6,7-Epoxy-latrunculin A Inhibitor / Unkown
HY-129934S Latanoprost ethyl amide-d4 / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown
HY-164401 QBS10072S Inducer / Unkown
HY-164401A QBS10072S dihydrochloride / Unkown
HY-175649 LATS1/2-IN-1 Inhibitor / Unkown
HY-181743 Piezo1 agonist 2 Agonist / Unkown
HY-182254 AChE/BChE-IN-35 Inhibitor / Unkown
HY-183147A LAT1-IN-2 hydrochloride Substrate / Unkown
HY-RS07536 LAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07537 LAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07539 LATS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09827 ORC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16816 Lat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17343 Lats1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18181 Lats2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21361 Lat2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23256 Lat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23797 Lats1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24655 Lats2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27880 Lat2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W246010 α,α-DiBn-DL-Gly Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LAT VGNC VGNC:42596
Rattus norvegicus LAT RGD RGD:620802
Mus musculus LAT MGD MGI:1342293
Bos taurus LAT VGNC VGNC:50054
Felis catus LAT VGNC VGNC:63199
Others LAT NCBI