2. Gene
  3. LAT - linker for activation of T cells Gene

LAT - linker for activation of T cells Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LAT1; pp36; IMD52

Gene ID: 27040 | Gene type: protein coding

About LAT

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,984,803-28,990,784 (from NCBI)

This gene has 16 transcripts (splice variants), 87 orthologues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 29.3), appendix (RPKM 13.0) and 19 other tissues.

Summary

The protein encoded by this gene is phosphorylated by ZAP-70/Syk Protein Tyrosine Kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LAT Products(4)

mRNA Protein Name
NM_001014987.2 NP_001014987.1 linker for activation of T-cells family member 1 isoform b
NM_001014988.2 NP_001014988.1 linker for activation of T-cells family member 1 isoform c
NM_001014989.2 NP_001014989.2 linker for activation of T-cells family member 1 isoform d
NM_014387.4 NP_055202.1 linker for activation of T-cells family member 1 isoform a

LAT Protein Structure

LAT

LAT: Linker for activation of T-cells (1 - 260)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

linker for activation of T-cells family member 1

36 kDa phospho-tyrosine adapter protein

Related Diseases

Diseases Alias
Immunodeficiency 52

Severe Combined Immunodeficiency Due To Lat Deficiency

IMD52

Scid Due To Lat Deficiency

Immunodeficiency, Type 52
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
Lymphopenia

Lymphocytopenia
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16929 Latrunculin A ≥98.0% Phase 4
Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138489 TRULI Modulator 99.98% Unkown
HY-108540 BCH Inducer ≥98.0% Unkown
HY-150042 TDI-011536 Inhibitor 99.91% Unkown
HY-147082 GA-017 Activator 98.92% Unkown
HY-W011391 GPNA hydrochloride 99.91% Unkown
HY-139330 MGH-CP1 Inducer 99.21% Unkown
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-120139 KMH-233 Inhibitor 98.11% Unkown
HY-130504 Propargyl-PEG1-acid ≥97.0% Unkown
HY-120139A (R)-KMH-233 / Unkown
HY-RS07536 LAT Human Pre-designed siRNA Set A / Unkown
HY-RS07537 LAT2 Human Pre-designed siRNA Set A / Unkown
HY-RS07538 LATS1 Human Pre-designed siRNA Set A / Unkown
HY-RS07539 LATS2 Human Pre-designed siRNA Set A / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown
HY-N3999 Venuloside A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LAT VGNC VGNC:42596
Rattus norvegicus LAT RGD RGD:620802
Mus musculus LAT MGD MGI:1342293
Bos taurus LAT VGNC VGNC:50054
Felis catus LAT VGNC VGNC:63199
Macaca fascicularis LAT NCBI
Canis lupus familiaris LAT NCBI
Susscrofa domestica LAT NCBI
Leporidae LAT NCBI
Macaca mulatta LAT NCBI
Others LAT NCBI