1. PROTAC
  2. PROTAC Linker
  3. Propargyl-PEG1-acid

Propargyl-PEG1-acid 

Cat. No.: HY-130504
Handling Instructions

Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM.

For research use only. We do not sell to patients.

Propargyl-PEG1-acid Chemical Structure

Propargyl-PEG1-acid Chemical Structure

CAS No. : 55683-37-9

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Description

Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1].

IC50 & Target

PEGs

 

In Vitro

BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment[1].

Molecular Weight

128.13

Formula

C₆H₈O₃

CAS No.

55683-37-9

SMILES

O=C(O)CCOCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Propargyl-PEG1-acidPROTAC LinkerInhibitorinhibitorinhibit

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Propargyl-PEG1-acid
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HY-130504
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