55683-37-9
Chemical Structure
Propargyl-PEG1-acid
- CAS No.: 55683-37-9
- Formula:C6H8O3
- Molecular Weight:128.13
IUPAC Name: 3-(prop-2-yn-1-yloxy)propanoic acid
InChIKey: GMFDYXLFHSFUHE-UHFFFAOYSA-N
SMILES: O=C(O)CCOCC#C
Biological Activity: Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM[1]. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Propargyl-PEG1-acid | 97.0% | Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Similarity Score 0.89
HY-W0260752-(Prop-2-yn-1-yloxy)acetic acid -
Similarity Score 0.86
HY-118764Propargyl-PEG2-acid -
Similarity Score 0.86
HY-W096146Propynyl-PEG1-Ac -
Similarity Score 0.84
HY-Y09255-Hexynoic acid -
Similarity Score 0.83
HY-Y12304-Pentynoic acid -
Similarity Score 0.82
HY-346436-Heptynoic acid -
Similarity Score 0.80
HY-151683H-L-Ser(Propargyl)-OH -
Similarity Score 0.80
HY-116655Hydroxy-PEG1-acid -
Similarity Score 0.80
HY-140002Amino-PEG1-C2-acid -
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