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Latrunculin A

(Synonyms: LAT-A)
12 Cited Publications
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Based on 12 publication(s) in Google Scholar

Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration.

For research use only. We do not sell to patients.

  • Purity: 98.9%
  • CAS No.: 76343-93-6
  • Formula: C22H31NO5S
  • Molecular Weight:421.55
  • Storage:

    Solution, -20°C, 2 years

  • Latrunculin A Chemical Structure
    Latrunculin A Chemical Structure
  • Experimental Validation Results for Latrunculin A
  • Experimental Validation Results for Latrunculin A
  • Experimental Validation Results for Latrunculin A
  • Experimental Validation Results for Latrunculin A
  • Experimental Validation Results for Latrunculin A
CAS No.: 76343-93-6
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  • In Vivo Efficacy Study
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  • Latrunculin A Chemical Structure
    Latrunculin A Chemical Structure
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    Latrunculin A purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Aug 28;e2203173. [Abstract]

    Customer Validation
     The sEVs (50 μg) were cocultured with macrophages (1 × 106) for 24 h. The sEVsHNSCC derived from two HNSCC lines: SCC25 and HN6. The sEVshBMSC-NT5EOE derived from hBMSC cells with NT5E overexpression. Latrunculin A (Lat A, 30 μM; 24 h) was used as the inhibitor of sEVs uptaken showed downregulated phagocytosis. The percentage of pHrodo dyes of M2 macrophages was analyzed by flow cytometry.

  • 1/16

    Latrunculin A purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Aug 28;e2203173. [Abstract]

    Customer Validation
     The expression of cytokines also increased when macrophages were cocultured with sEVs derived from hBMSCs overexpressing CD73, whereas this trend was reversed by Latrunculin A (Lat A, 30 μM; 24 h).

  • 1/16

    Latrunculin A purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Aug 28;e2203173. [Abstract]

    Customer Validation
     Macrophages were cocultured with anti-CD73-FITC labelled sEVs from HNSCC cell lines control or RABAKO, CD73-GFP labelled sEVs from hBMSC treated with or without Latrunculin A (Lat A, 30 μM; 24 h) were cocultured with macrophages for 1 h, and Laser Scanning Confocal Microscopy was used to analyze the internalization of HNSCC-derived sEVs into macrophages (Scale bar = 25 μm).

  • 1/16

    Latrunculin A purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Aug 28;e2203173. [Abstract]

    Customer Validation
     Absence of CD73 in sEVs rescues immune suppression and restrains tumour growth in C3H/He mice aged 6–8 weeks. (a) Schematic of subcutaneous tumorigenesis in vivo experiment, followed with intratumoral injection of sEVs which were collected from SCC7, SCC7-Nt5eKO or SCC7-Nt5eOE cells grown in vitro. (b) The exhibition of isolated tumours. (c and d) The tumour weight and the time course of tumour growth in grams for 15 days postinjection with SCC7 or SCC7Rab27aKO cells with or without CD73 in sEVs. Latrunculin A (Lat A, 0.15 mg/kg; ip; every 2 days for 15 days) was used as inhibitor of sEVs uptaken.

  • 1/16

    Latrunculin A purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2022 Aug 28;e2203173. [Abstract]

    Customer Validation
     Latrunculin A (Lat A, 0.15 mg/kg; ip; every 2 days for 15 days) was used as an inhibitor of sEVs uptake in C3H/He mice aged 6–8 weeks. Flow cytometry analysis for infiltration of Tregs and percentage of CD73+/PD-1+ Tregs in tumours.

  • Latrunculin A