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  2. Arp2/3 Complex
  3. Latrunculin A

Latrunculin A (Synonyms: LAT-A)

Cat. No.: HY-16929 Purity: ≥95.0%
Handling Instructions

Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research.

For research use only. We do not sell to patients.

Latrunculin A Chemical Structure

Latrunculin A Chemical Structure

CAS No. : 76343-93-6

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Solution
100 μg (237.2 µM * 1mL in Ethanol) USD 430 In-stock
Estimated Time of Arrival: December 31

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Based on 2 publication(s) in Google Scholar

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Description

Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research[1][2].

IC50 & Target

Kd: 0.1 μM (ATP-actin), 0.4 μM (ADP-Pi-actin), 4.7 μM (ADP-actin), 0.19 μM (G-actin)[2]

In Vitro

Latrunculin A (50-1000 nM) exhibits potent anti-invasive activity against human prostate cancer PC-3M cells, inhibits PC-3M-CT+ spheroids disaggregation and cell migration[3].
Latrunculin A (3-30 μM) inhibits hypoxia-induced HIF-1 activation with an IC50 value of 6.7 μM in human breast carcinoma T47D cells[3].
Latrunculin A (0-0.2 μM, 4 hours) has a significant inhibitory effect on HuR levels at high concentrations such as 0.2 μM in human hepatoma HepG2 cells while inhibits HuR only at 0.02 μM but no inhibitory effect at high concentrations in human hepatoma Huh7 cells[4].
Latrunculin A (0.1 μM, 24 hours) can lead to a significant decrease in cell migration and has an inhibitory effect on cell proliferation in human hepatoma cell lines HepG2[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Latrunculin A (intraperitoneal injection, 0.05 mg/kg, three doses in the first 20 days, 120 days) has strong antitumor effect in male BALB/c nude mice models infected with adenocarcinoma (MKN45) or carcinoma (NUGC-4)[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c nude mice models infected with adenocarcinoma (MKN45) or carcinoma (NUGC-4)[5]
Dosage: 0.05 mg/kg
Administration: Intraperitoneal injection; three doses in the first 20 days; 120 days
Result: Extended the mean life expectancy to 23.5 days comparing to control of 16 days in adenocarcinoma (MKN45) mice and the mean survival time was 42 days comparing to untreated of 31 days in carcinoma (NUGC-4) mice.
Clinical Trial
Molecular Weight

421.55

Formula

C22H31NO5S

CAS No.
SMILES

O=C1SC[[email protected]@H]([[email protected]]2(O)O[[email protected]]3([H])CC[[email protected]](C)/C=C\C=C\CC/C(C)=C\C(O[[email protected]@](C3)([H])C2)=O)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Purity & Documentation

Purity: ≥98.0%

References
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