76343-93-6
Chemical Structure
Latrunculin A
Synonym(s): LAT-A
- CAS No.: 76343-93-6
- Formula:C22H31NO5S
- Molecular Weight:421.55
IUPAC Name: (R)-4-((1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)thiazolidin-2-one
InChIKey: DDVBPZROPPMBLW-IZGXTMSKSA-N
SMILES: O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1
Biological Activity:
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration[1][2][3][4][5][6].
The product specifications provided below refer solely to the active content of Latrunculin A.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Latrunculin A | 96.7% | Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration. The product specifications provided below refer solely to the active content of Latrunculin A. |
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Similarity Score 0.92
HY-101848Latrunculin B -
Similarity Score 0.92
HY-101848A16-epi-Latrunculin B -
Similarity Score 0.81
HY-1270426,7-Epoxy-latrunculin A -
Similarity Score 0.44
HY-125539Roridin E -
Similarity Score 0.43
HY-126906RMilbemycin A4 (Standard) -
Similarity Score 0.42
HY-130423RMilbemycin A3 (Standard) -
Similarity Score 0.42
HY-18979Lactimidomycin -
Similarity Score 0.42
HY-N1353711β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester -
Similarity Score 0.41
HY-N10113Verrucarin J -
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References
- [1]. Fujiwara I, et al. Latrunculin A Accelerates Actin Filament Depolymerization in Addition to Sequestering Actin Monomers. Curr Biol. 2018 Oct 8;28(19):3183-3192.e2. [Content Brief]
- [2]. Coué M, et al. Inhibition of actin polymerization by latrunculin A. FEBS Lett. 1987 Mar 23;213(2):316-8. [Content Brief]
- [3]. Khalid A El Sayed, et al. Latrunculin A and its C-17-O-carbamates inhibit prostate tumor cell invasion and HIF-1 activation in breast tumor cells. J Nat Prod. 2008 Mar;71(3):396-402. [Content Brief]
- [4]. Anke Doller, et al. The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking. Exp Cell Res. 2015 Jan 1;330(1):66-80. [Content Brief]
- [5]. Hiroo Konishi, et al. Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice. Anticancer Res. 2009 Jun;29(6):2091-7. [Content Brief]
- [6]. Liang Ma, et al. Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration. Cell Res. 2015 Jan;25(1):24-38. [Content Brief]
