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Latrunculin B 

Cat. No.: HY-101848
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Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity.

For research use only. We do not sell to patients.

Latrunculin B Chemical Structure

Latrunculin B Chemical Structure

CAS No. : 76343-94-7

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Description

Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis[1][2]. Antifungal and antiprotozoal activity.

In Vitro

Latrunculin B displays growth inhibition of HeLa cells with an IC50 value of 1.4 μM[1].
Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K+ current and ultra-rapid delayed rectifier K+ current, but increases the delayed rectifier K+ current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

395.51

Formula

C₂₀H₂₉NO₅S

CAS No.
SMILES

O=C1SC[[email protected]@H]([[email protected]]2(O)O[[email protected]]3([H])CC[[email protected]](C)/C=C\CC/C(C)=C\C(O[[email protected]@](C3)([H])C2)=O)N1

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Keywords:

Latrunculin BFungalantimicrobialmarinealkaloidactinpolymerizationpulmonaryveinelectrophysiologicalstretcharrhythmogenesisInhibitorinhibitorinhibit

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Latrunculin B
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