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Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity.

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Latrunculin B Chemical Structure

Latrunculin B Chemical Structure

CAS No. : 76343-94-7

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Based on 1 publication(s) in Google Scholar

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Description

Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity[1][2].

In Vitro

Latrunculin B displays growth inhibition of HeLa cells with an IC50 value of 1.4 μM[1].
Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K+ current and ultra-rapid delayed rectifier K+ current, but increases the delayed rectifier K+ current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

395.51

Formula

C20H29NO5S

CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1

Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (63.21 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5284 mL 12.6419 mL 25.2838 mL
5 mM 0.5057 mL 2.5284 mL 5.0568 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5284 mL 12.6419 mL 25.2838 mL 63.2095 mL
5 mM 0.5057 mL 2.5284 mL 5.0568 mL 12.6419 mL
10 mM 0.2528 mL 1.2642 mL 2.5284 mL 6.3210 mL
15 mM 0.1686 mL 0.8428 mL 1.6856 mL 4.2140 mL
20 mM 0.1264 mL 0.6321 mL 1.2642 mL 3.1605 mL
25 mM 0.1011 mL 0.5057 mL 1.0114 mL 2.5284 mL
30 mM 0.0843 mL 0.4214 mL 0.8428 mL 2.1070 mL
40 mM 0.0632 mL 0.3160 mL 0.6321 mL 1.5802 mL
50 mM 0.0506 mL 0.2528 mL 0.5057 mL 1.2642 mL
60 mM 0.0421 mL 0.2107 mL 0.4214 mL 1.0535 mL
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Latrunculin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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