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Latrunculin B 

Cat. No.: HY-101848 Purity: ≥98.0%
COA Handling Instructions

Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity.

For research use only. We do not sell to patients.

Latrunculin B Chemical Structure

Latrunculin B Chemical Structure

CAS No. : 76343-94-7

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1 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity[1][2].

In Vitro

Latrunculin B displays growth inhibition of HeLa cells with an IC50 value of 1.4 μM[1].
Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K+ current and ultra-rapid delayed rectifier K+ current, but increases the delayed rectifier K+ current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

395.51

Formula

C20H29NO5S

CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1

Initial Source

Red Sea sponge

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (63.21 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5284 mL 12.6419 mL 25.2838 mL
5 mM 0.5057 mL 2.5284 mL 5.0568 mL
10 mM 0.2528 mL 1.2642 mL 2.5284 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

References
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Latrunculin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Latrunculin B
Cat. No.:
HY-101848
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