76343-94-7
Chemical Structure
Latrunculin B
- CAS No.: 76343-94-7
- Formula:C20H29NO5S
- Molecular Weight:395.51
IUPAC Name: (R)-4-((1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl)thiazolidin-2-one
InChIKey: NSHPHXHGRHSMIK-JRIKCGFMSA-N
SMILES: O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1
Biological Activity: Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity[1][2].
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Latrunculin B | 98.95% | Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity. | ||||||||||||||||||||
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- [1]. Diaa T A Youssef, et al. Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5( 3H,6H)-dione Backbone from the Red Sea Sponge Negombata magnifica. Mar Drugs. 2021 Apr 12;19(4):214. [Content Brief]
- [2]. Yen-Yu Lu, et al. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Clin Sci (Lond). 2016 May;130(9):721-32. [Content Brief]
Keywords
