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Cat. No.: HY-125539

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Roridin E

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Roridin E is a glucose-6-phosphatase (G6Pase) inhibitor and antibiotic, and is a metabolic byproduct of Roridin A (HY-N9599). Roridin E induces significant oxidative stress, characterized by depletion of glutathione in vivo, induction of hepatic lipid peroxidation, and inhibition of renal superoxide dismutase activity. Roridin E reduces blood glucose levels in rats, but exhibits acute toxicity (which is enhanced when co-administered with linoleic acid (HY-N0729)) and causes hepatotoxicity in male albino mice. Roridin E induces a decrease in total blood protein and increases in the levels of total lipids, γ-glutamyltransferase, alkaline phosphatase, and 5'-nucleotidase. Roridin E can be isolated from molds, and possesses cytostatic and antifungal activities similar to those of Verrucarin A (HY-107426) and Roridin A. Roridin E exhibits in vivo activity in rodents and is commonly used in hepatotoxicity-related studies.

For research use only. We do not sell to patients.

Purity: 99.89%
CAS No.: 16891-85-3
Formula: C₂₉H₃₈O₈
Molecular Weight:514.61

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Roridin E Chemical Structure

CAS No.: 16891-85-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Antibiotic Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	<9.7 μM Compound: Roridin E	Cytotoxicity against human A549 cells after 72 hrs Cytotoxicity against human A549 cells after 72 hrs	[PMID: 21907583]
BT-549	IC₅₀	uM μM Compound: 4	Cytotoxicity against human BT549 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human BT549 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 30457333]
HCC70	IC₅₀	uM μM Compound: 4	Cytotoxicity against human HCC70 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human HCC70 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 30457333]
HL-60	IC₅₀	0.3 ng/mL Compound: 2	Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay	[PMID: 11277768]
K562	IC₅₀	0.54 μM Compound: 11	Cytotoxicity against human K562 cells by disk diffusion soft agar colony formation assay Cytotoxicity against human K562 cells by disk diffusion soft agar colony formation assay	[PMID: 31117520]
KB	EC₅₀	0.5 ng/mL Compound: 4	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 10075777]
L1210	IC₅₀	0.2 ng/mL Compound: 2	Cytotoxicity against mouse L1210 cells after 72 hrs by WST8 assay Cytotoxicity against mouse L1210 cells after 72 hrs by WST8 assay	[PMID: 11277768]
MDA-MB-231	IC₅₀	uM μM Compound: 4	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 30457333]
MDA-MB-468	IC₅₀	uM μM Compound: 4	Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-468 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 30457333]
SW 1116	IC₅₀	0.039 μM Compound: 11	Cytotoxicity against human SW1116 cells by disk diffusion soft agar colony formation assay Cytotoxicity against human SW1116 cells by disk diffusion soft agar colony formation assay	[PMID: 31117520]
Vero	EC₅₀	0.4 ng/mL Compound: 4	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 10075777]

In Vivo

Roridin E (2 mg/kg; s.c.; single dose) produces a significant increase in liver glucose-6-phosphatase activity and kidney glutathione levels, with no significant changes in other measured serum, liver, or kidney biochemical parameters in male Sprague-Dawley rats^[1].
Roridin E (2 mg/kg; i.p.; single dose) induces significant hepatotoxicity in male albino mice, as evidenced by increased liver oxidative stress markers and altered serum liver function parameters^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, 150-170 g)^[1]
Dosage:

2 mg/kg
Administration:

s.c.; single dose
Result:

Showed no significant changes in levels of TBARS, total lipids, glucose, glutathione, creatinine, zinc, or calcium in serum compared to controls.
Increased liver glucose-6-phosphatase activity to 10.6 nmol/min/mg proteins, with no significant changes in TBARS, total lipid, glutathione, 5-nucleotidase, or superoxide dismutase levels in liver compared to controls.
Increased kidney glutathione level to 6.76 μg/mg proteins, with no significant changes in TBARS, total lipid, 5-nucleotidase, glucose-6-phosphatase, or superoxide dismutase levels in kidney compared to controls.

Animal Model:

albino mice (male, 6 weeks old, 20-25 g)^[2]
Dosage:

2 mg/kg
Administration:

i.p.; single dose
Result:

Increased liver tissue TBARs to 2.3 mmol/mL.
Increased liver tissue SOD to 1.9 ng/mL.
Increased liver tissue GSH to 2.9 mmol/mL.
Decreased blood serum total protein to 4.4 g/dl.
Increased blood serum total lipids to 5.8 mg/mL.
Increased blood serum GGT to 32.1 u/mL.
Increased blood serum alkaline phosphatase to 116 u/L.
Increased blood serum 5'-nucleotidase to 1.8 u/mL.

Chemical Information

CAS No. 16891-85-3
Appearance Solid
Molecular Weight 514.61
Formula C₂₉H₃₈O₈
Color White to off-white
SMILES

C[C@@]12[C@]3(CO3)[C@@]4([H])C[C@@]1([H])OC(/C=C\C=C\[C@@]([C@H](O)C)([H])OCC/C(C)=C/C(OC[C@]25[C@](C=C(C)CC5)([H])O4)=O)=O
Structure Classification
- Others
Initial Source
- Microorganisms
Myrothecium verrucaria
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Omar H E D M, et al. Acute toxicity of the mycotoxin roridin E on liver and kidney of rats[J]. Journal of Applied Animal Research, 1997, 12(2): 145-152.

[2]. Qusti S Y, et al. Effect of Nigella sativa L. oil on roridin E toxin administration on liver of male mice[J]. Journal of Applied Animal Research, 2007, 31(2): 161-164.

[3]. Böhner B, et al. Über die Isolierung von Verrucarin H, Verrucarin J, Roridin D und Roridin E aus Myrothecium‐Arten. Verrucarine und Roridine, 8. Mitteilung[J]. Helvetica Chimica Acta, 1965, 48(5): 1079-1087.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Roridin E

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Roridin E Related Classifications

HY-125539 Related Classifications