1. Apoptosis
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Apoptosis
    Reactive Oxygen Species
  3. Verrucarin A

Verrucarin A (Synonyms: Muconomycin A)

Cat. No.: HY-107426 Purity: ≥98.0%
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Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53.

For research use only. We do not sell to patients.

Verrucarin A Chemical Structure

Verrucarin A Chemical Structure

CAS No. : 3148-09-2

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Description

Verrucarin A (Muconomycin A), a Type D macrocyclic mycotoxin derived from the pathogen fungus Myrothecium verrucaria, is an inhibitor of protein synthesis. Verrucarin A inhibits growth of leukemia cell lines and activates caspases and apoptosis and inflammatory signaling in macrophages. Verrucarin A effectively increased the phosphorylation of p38 MAPK and diminished the phosphorylation of ERK/Akt. Verrucarin A caused cell cycle deregulation through the induction of p21 and p53[1][2].

In Vitro

Verrucarin A (0-0.6 μM/ml; 24-48 hours)-induces time- and dose-dependent growth inhibition in MCF-7 cells[1].
Verrucarin A increases the levels of reactive oxygen species (ROS), and subsequently induces mitochondrial membrane potential (Δψm) loss, leading to the increase of Bax/Bcl-2 ratio, cytochrome c release, caspase activation, PARP degradation, and apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 0-0.6 μM/ml
Incubation Time: 24 and 48 hours
Result: Growth of MCF-7 cells is significantly inhibited in a dose- and time-dependent manner, with the IC50s of 0.41 and 0.29 μM/ml for 24- and 48-h treatment periods, respectively.
Molecular Weight

502.55

Formula

C₂₇H₃₄O₉

CAS No.
SMILES

C[[email protected]@]12[[email protected]]3(CO3)[[email protected]@]4([H])C[[email protected]@]1([H])OC(/C=C/C=C/C(OCC[[email protected]@H](C)[[email protected]](O)C(OC[[email protected]]25[[email protected]](C=C(C)CC5)([H])O4)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥98.0%

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Keywords:

Verrucarin AMuconomycin AApoptosisReactive Oxygen SpeciesmitochondrialmembranedegradationinflammatoryphosphorylationmacrophagesInhibitorinhibitorinhibit

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Verrucarin A
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