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  4. Roridin A

Roridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita).

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Roridin A

Roridin A Chemical Structure

CAS No. : 14729-29-4

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Description

Roridin A acts as an inhibitor of pollen development in Arabidopsis thaliana and nematicide. Roridin A is isolated from the fungus Cylindrocarpon sp. Roridin A delays the flowering time of Arabidopsis thaliana, inhibits pollen development and stem elongation, and blocks plant growth. Roridin A induces larval death of the southern root-knot nematode (Meloidogyne incognita)[1][2].

IC50 & Target[1]

Fungal Metabolite

 

In Vivo

Roridin A (0.6-60 μM) delays flowering time, inhibits pollen development and stem elongation, and blocks plant growth in Arabidopsis thaliana[1].
Roridin A (24-500 μg/mL) completely inhibits cucumber root knot formation induced by Meloidogyne incognita at the dose of 24 μg/mL, and reduces root knot formation at the dose of 500 μg/mL[2].
Roridin A (7 days) potently induces the death of juveniles of Meloidogyne incognita (southern root-knot nematode) hatched from treated eggs, with an LD50 of 1.50 μg/mL[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Arabidopsis thaliana[1]
Dosage: 0.6 μM, 2 μM, 6 μM, 20 μM, 60 μM
Administration: incorporated into solid growth medium at seeding; continuous exposure
Result: Showed no inhibitory effect on plant growth, no delay in bolting or flowering time, and no impact on stem length relative to control at 0.6 μM.
Did not delay bolting time, but delayed flowering time; inhibited pollen development, resulting in anthers with collapsed structures and no viable pollen, and blocked female fertility (no seed formation via hand pollination with untreated pollen); reduced stem length to first flowering to 17 mm at 2 μM.
Completely inhibited plant growth (no germination) at 6 μM, 20 μM, and 60 μM.
Molecular Weight

532.62

Formula

C29H40O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@H]1CCO[C@@H]([C@H](O)C)/C=C\C=C/C(O[C@@H]2C[C@@H]3[C@@]4(CO4)[C@@]2(C)[C@@]5(COC([C@H]1O)=O)CCC(C)=C[C@H]5O3)=O
Structure Classification
Initial Source

Cylindrocarpon sp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (18.78 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8775 mL 9.3876 mL 18.7751 mL
5 mM 0.3755 mL 1.8775 mL 3.7550 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.49%

SDS (420 KB)

COA (259 KB) RP-HPLC (370 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8775 mL 9.3876 mL 18.7751 mL 46.9378 mL
5 mM 0.3755 mL 1.8775 mL 3.7550 mL 9.3876 mL
10 mM 0.1878 mL 0.9388 mL 1.8775 mL 4.6938 mL
15 mM 0.1252 mL 0.6258 mL 1.2517 mL 3.1292 mL
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Roridin A Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

Roridin A14729-29-4FungalEndogenous MetaboliteParasiteInsecticideCylindrocarpon sp.microspore-stage pollen developmentArabidopsis thalianaegg hatchingMyrothecium verrucariatapetal cellroot-knot nematode diseasejuvenile mortalityMeloidogyne incognitacucumber rootsInhibitorinhibitorinhibit

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