Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria

  • J Nat Prod. 1999 Feb;62(2):329-31. doi: 10.1021/np980323x.
M Isaka  1 ,  J Punya ,  Y Lertwerawat ,  M Tanticharoen ,  Y Thebtaranonth
Affiliations
  • 1. National Center for Genetic Engineering and Biotechnology (BIOTEC), Rama 6 Road, Bangkok 10400, Thailand. [email protected]
PMID: 10075777 DOI: 10.1021/np980323x
Abstract

Bioassay-guided fractionation of an extract from the fungus Myrothecium verrucaria BCC 112 resulted in the first isolation of roridin E acetate (5) from nature together with four common macrocyclic trichothecene isomers (1-4). Trichothecenes 1-5, while known as mycotoxins, were evaluated for their high antimalarial activity.