α,α-DiBn-DL-Gly  (Synonyms: Dibenzylglycine)

α,α-DiBn-DL-Gly (Dibenzylglycine) is an achiral α-substituted phenylalanine derivative, non-substrate weak inhibitor of LAT1 (L-type amino acid transporter 1). α,α-DiBn-DL-Gly does not stimulate efflux of-Gabapentin from preloaded HEK-hLAT1 cells. α,α-DiBn-DL-Gly shows minimal inhibition of-Gabapentin (HY-A0057) uptake into HEK-hLAT1 cells^[1].

α,α-DiBn-DL-Gly (200 μM; 3 min) does not act as a LAT1 substrate in induced TREx HEK-hLAT1 cells, as evidenced by its 23% relative exchange efflux rate^[1].
α,α-DiBn-DL-Gly (200 μM; 3 min) shows minimal inhibitory activity against LAT1 in induced TREx HEK-hLAT1 cells, as evidenced by its 11% uptake inhibition of [³H]-gabapentin at 200 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

255.31

C₁₆H₁₇NO₂

6278-96-2

O=C(C(CC1=CC=CC=C1)(CC2=CC=CC=C2)N)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chien HC, et al. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem. 2018;61(16):7358-7373.  [Content Brief]