2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Gabapentin

Gabapentin 

Cat. No.: HY-A0057 Purity: ≥98.0%
COA Handling Instructions

Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain.

For research use only. We do not sell to patients.

Gabapentin Chemical Structure

Gabapentin Chemical Structure

CAS No. : 60142-96-3

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Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 In-stock
Solution
10 mM * 1 mL in Water USD 33 In-stock
Solid
10 mg USD 30 In-stock
50 mg USD 65 In-stock
100 mg USD 90 In-stock
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Based on 8 publication(s) in Google Scholar

Other Forms of Gabapentin:

Gabapentin Related Antibodies

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Description

Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain[1][2][3].

In Vitro

Gabapentin (0-300 μM) produces a concentration-dependent inhibition of the K+-induced [Ca2+]i increase in synaptosomes (IC50=14?μM; maximal inhibition by 36%)[1].
? Gabapentin (100? μM) decreases the K+-evoked release of endogenous aspartate and glutamate in neocortical slices by 16 and 18%, respectively[1].
? Gabapentin (0-1000 μM) reduces the K+-evoked [3H]-noradrenaline release in neocortical slices (IC50=48?μM; maximal inhibition of 46%) but not from synaptosomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gabapentin Related Antibodies
In Vivo

Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks[2].
? Gabapentin (1-100 mg/kg; i.p.; once; male mice) has analgesic effect and reduces writhing in a dose-dependent manner[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice (35-45 g)[2]
Dosage: 5 and 10 mg/kg
Administration: Intraperitoneal injection; once
Result: Increased the time spent in target quadrant and decreased the distance to platform in MWM test
. Decreased the transfer latency on second day in mEPM test
. Prolonged retention latency in PA test
.
Animal Model: Male mice (26-30 g)[3]
Dosage: 1, 5, 10, 50 and 100 mg/kg
Administration: Intraperitoneal injection; once
Result: Produced 45-70% inhibition of writhing.
Clinical Trial
Molecular Weight

171.24

Appearance

Solid

Formula

C9H17NO2
CAS No.
SMILES

O=C(O)CC1(CN)CCCCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (291.99 mM; Need ultrasonic)

DMSO : 1 mg/mL (5.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8398 mL 29.1988 mL 58.3976 mL
5 mM 1.1680 mL 5.8398 mL 11.6795 mL
10 mM 0.5840 mL 2.9199 mL 5.8398 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (145.99 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (251 KB) HNMR (179 KB)

Handling Instructions (2659 KB)
References
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Gabapentin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Gabapentin60142-96-3Calcium ChannelCa2+ channelsCa channelsCa2+neurotransmitterGABA analogneuropathic painInhibitorinhibitorinhibit

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